Imperial College London

Dr Charlotte Dean

Faculty of MedicineNational Heart & Lung Institute

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3174c.dean

 
 
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Location

 

360Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Oozeer:2017:10.1038/s41598-017-01971-2,
author = {Oozeer, F and Yates, LL and Dean, C and Formstone, CJ},
doi = {10.1038/s41598-017-01971-2},
journal = {SCIENTIFIC REPORTS},
title = {A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin},
url = {http://dx.doi.org/10.1038/s41598-017-01971-2},
volume = {7},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The question of how cell division orientation is determined is fundamentally important for understanding tissue and organ shape in both healthy or disease conditions. Here we provide evidence for cell contact-dependent orientation of planar cell division in the mammalian embryonic skin. We propose a model where the core planar polarity proteins Celsr1 and Frizzled-6 (Fz6) communicate the long axis orientation of interphase basal cells to neighbouring basal mitoses so that they align their horizontal division plane along the same axis. The underlying mechanism requires a direct, cell surface, planar polarised cue, which we posit depends upon variant post-translational forms of Celsr1 protein coupled to Fz6. Our hypothesis has parallels with contact-mediated division orientation in early C. elegans embryos suggesting functional conservation between the adhesion-GPCRs Celsr1 and Latrophilin-1. We propose that linking planar cell division plane with interphase neighbour long axis geometry reinforces axial bias in skin spreading around the mouse embryo body.
AU - Oozeer,F
AU - Yates,LL
AU - Dean,C
AU - Formstone,CJ
DO - 10.1038/s41598-017-01971-2
PY - 2017///
SN - 2045-2322
TI - A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
T2 - SCIENTIFIC REPORTS
UR - http://dx.doi.org/10.1038/s41598-017-01971-2
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401262700013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/49036
VL - 7
ER -