DrCorneliusDonat

Faculty of Medicine, Department of Brain Sciences

Honorary Associate

Contact

Location

Burlington DanesHammersmith Campus

Summary

I am a biologist working with Prof David J. Sharp and Dr Magdalena Sastre at the Department of Medicine, Imperial College.

My main research interests are disorders of the brain, primarily Traumatic Brain Injury (TBI), the connection with dementia and the underlying molecular processes. I have a particular interest in nicotinic acetylcholine receptors and how they are involved in cognitive dysfunction and inflammatory processes during TBI and neurodegenerative diseases. I have worked on the visualisation of these receptors with radioactive imaging techniques and will evaluate receptor-specific therapies in TBI and neurodegenerative diseases.

One of my research aims is to increase the understanding of the pathophysiological processes following TBI and how neuro- and molecular imaging can be used to identify major disease processes in order to support the development of new treatment strategies. For that purpose, I am employing models of TBI that reduce the complexity of the injury and allow the selective pharmacological manipulation.

Apart from neuroscience, I am also interested in the structure of totalitarian states, the organizational and linguistic strategies they employ and the dynamic interplay between groups, individuals and society.

Publications

Journals

Naseer S, Abelleira Hervas L, Savani D, et al.Naseer S, Abelleira Hervas L, Savani D, De Burgh R, Aleksynas R, Donat C, Syed N, Sastre M close, 2022, Traumatic brain injury leads to alterations in contusional cortical miRNAs involved in dementia, Biomolecules, Vol:12, ISSN:2218-273X

Graham NSN, Zimmerman KA, Moro F, et al.Graham NSN, Zimmerman KA, Moro F, Heslegrave A, Maillard SA, Bernini A, Miroz J-P, Donat CK, Lopez MY, Bourke N, Jolly AE, Mallas E-J, Soreq E, Wilson MH, Fatania G, Roi D, Patel MC, Garbero E, Nattino G, Baciu C, Fainardi E, Chieregato A, Gradisek P, Magnoni S, Oddo M, Zetterberg H, Bertolini G, Sharp DJ close, 2021, Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury, Science Translational Medicine, Vol:13, ISSN:1946-6234, Pages:1-15

Calsolaro V, Matthews PM, Donat CK, et al.Calsolaro V, Matthews PM, Donat CK, Livingston NR, Femminella GD, Guedes SS, Myers J, Fan Z, Tyacke RJ, Venkataraman AV, Perneczky R, Gunn R, Rabiner EA, Gentleman S, Parker CA, Murphy PS, Wren PB, Hinz R, Sastre M, Nutt DJ, Edison P close, 2021, Astrocyte reactivity with late onset cognitive impairment assessed in-vivo using 11C-BU99008 PET and its relationship with amyloid load, Molecular Psychiatry, Vol:26, ISSN:1359-4184, Pages:5848-5855

Farajzadeh Khosroshahi S, Yin X, Donat C, et al.Farajzadeh Khosroshahi S, Yin X, Donat C, McGarry A, Yanez Lopez M, Baxan N, Sharp D, Sastre M, Ghajari M close, 2021, Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses, Scientific Reports, Vol:11, ISSN:2045-2322

Ries M, Watts H, Mota B, et al.Ries M, Watts H, Mota B, Yanez Lopez M, Donat C, Baxan N, Pickering J, Chau TSZ, Semmler A, Gurung B, Aleksynas R, Abelleira Hervas L, Iqbal S, Romero-Molina C, Hernandez Mir G, d'Amati A, Reutelingsperger C, Goldfinger M, Gentleman S, Van Leuven F, Solito E, Sastre M close, 2021, Annexin-A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology, Brain: a Journal of Neurology, Vol:144, ISSN:0006-8950, Pages:1526-1541

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