Imperial College London

DrCorneliusDonat

Faculty of MedicineDepartment of Medicine

Research Associate
 
 
 
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Contact

 

c.donat

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Summary

I am a biologist working with Prof David J. Sharp and Dr Magdalena Sastre at the Department of Medicine, Imperial College.

My main research interests are disorders of the brain, primarily Traumatic Brain Injury (TBI), the connection with dementia and the underlying molecular processes. I have a particular interest in nicotinic acetylcholine receptors and how they are involved in cognitive dysfunction and inflammatory processes during TBI and neurodegenerative diseases. I have worked on the visualisation of these receptors with radioactive imaging techniques and will evaluate receptor-specific therapies in TBI and neurodegenerative diseases.

One of my research aims is to increase the understanding of the pathophysiological processes following TBI and how neuro- and molecular imaging can be used to identify major disease processes in order to support the development of new treatment strategies. For that purpose, I am employing models of TBI that reduce the complexity of the injury and allow the selective pharmacological manipulation.

Apart from neuroscience, I am also interested in the structure of totalitarian states, the organizational and linguistic strategies they employ and the dynamic interplay between groups, individuals and society.

Publications

Journals

Donat CK, Scott G, Gentleman SM, et al., 2017, Microglial Activation in Traumatic Brain Injury, Frontiers in Aging Neuroscience, Vol:9, ISSN:1663-4365

Donat CK, Gaber K, Meixensberger J, et al., 2016, Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury, Neuromolecular Medicine, Vol:18, ISSN:1535-1084, Pages:158-169

Kranz M, Sattler B, Tiepolt S, et al., 2016, Radiation dosimetry of the alpha(4)beta(2) nicotinic receptor ligand (+)-[F-18]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results, Ejnmmi Physics, Vol:3, ISSN:2197-7364

Kranz M, Sattler B, Wuest N, et al., 2016, Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [F-18]FluspidineA New Tracer in Clinical Translation for Imaging of sigma(1) Receptors, Molecules, Vol:21, ISSN:1420-3049

Ludwig F-A, Smits R, Fischer S, et al., 2016, LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[F-18]FlubatineA Positron Emission Tomography Radioligand for Imaging 42 Nicotinic Acetylcholine Receptors, Molecules, Vol:21, ISSN:1420-3049

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