Imperial College London
Alternate

ProfessorChristopheFraser

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.fraser Website

 
 
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Location

 

G28Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lehtinen:2019:10.1371/journal.ppat.1007763,
author = {Lehtinen, S and Blanquart, F and Lipsitch, M and Fraser, C and Bentley, SD and Croucher, NJ and Lees, JA and Turner, P},
doi = {10.1371/journal.ppat.1007763},
journal = {PLoS Pathogens},
title = {On the evolutionary ecology of multidrug resistance in bacteria},
url = {http://dx.doi.org/10.1371/journal.ppat.1007763},
volume = {15},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Resistance against different antibiotics appears on the same bacterial strains more oftenthan expected by chance, leading to high frequencies of multidrug resistance. There are multiple explanations for this observation, but these tend to be specific to subsets of antibioticsand/or bacterial species, whereas the trend is pervasive. Here, we consider the questionin terms of strain ecology: explaining why resistance to different antibiotics is often seen onthe same strain requires an understanding of the competition between strains with differentresistance profiles. This work builds on models originally proposed to explain another aspectof strain competition: the stable coexistence of antibiotic sensitivity and resistance observedin a number of bacterial species. We first identify a partial structural similarity in these models: either strain or host population structure stratifies the pathogen population into evolutionarily independent sub-populations and introduces variation in the fitness effect of resistancebetween these sub-populations, thus creating niches for sensitivity and resistance. We thengeneralise this unified underlying model to multidrug resistance and show that models withthis structure predict high levels of association between resistance to different drugs andhigh multidrug resistance frequencies. We test predictions from this model in six bacterialdatasets and find them to be qualitatively consistent with observed trends. The higher thanexpected frequencies of multidrug resistance are often interpreted as evidence that thesestrains are out-competing strains with lower resistance multiplicity. Our work provides analternative explanation that is compatible with long-term stability in resistance frequencies.
AU  - Lehtinen,S
AU  - Blanquart,F
AU  - Lipsitch,M
AU  - Fraser,C
AU  - Bentley,SD
AU  - Croucher,NJ
AU  - Lees,JA
AU  - Turner,P
DO  - 10.1371/journal.ppat.1007763
PY  - 2019///
SN  - 1553-7366
TI  - On the evolutionary ecology of multidrug resistance in bacteria
T2  - PLoS Pathogens
UR  - http://dx.doi.org/10.1371/journal.ppat.1007763
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000471180400026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/71339
VL  - 15
ER  -
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