Imperial College London
Alternate

ProfessorChristopheFraser

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.fraser Website

 
 
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Location

 

G28Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dudas:2017:10.1038/nature22040,
author = {Dudas, G and Carvalho, LM and Bedford, T and Tatem, AJ and Baele, G and Faria, NR and Park, DJ and Ladner, JT and Arias, A and Asogun, D and Bielejec, F and Caddy, SL and Cotten, M and D'Ambrozio, J and Dellicour, S and Di, Caro A and Diclaro, JW and Duraffour, S and Elmore, MJ and Iii, LSF and Faye, O and Gilbert, ML and Gevao, SM and Gire, S and Gladden-Young, A and Gnirke, A and Goba, A and Grant, DS and Haagmans, BL and Hiscox, JA and Jah, U and Kugelman, JR and Liu, D and Lu, J and Malboeuf, CM and Mate, S and Matthews, DA and Matranga, CB and Meredith, LW and Qu, J and Quick, J and Pas, SD and Phan, MVT and Pollakis, G and Reusken, CB and Sanchez-Lockhart, M and Schaffner, SF and Schieffelin, JS and Sealfon, RS and Simon-Loriere, E and Smits, SL and Stoecker, K and Thorne, L and Tobin, EA and Vandi, MA and Watson, SJ and West, K and Whitmer, S and Wiley, MR and Winnicki, SM and Wohl, S and Wolfel, R and Yozwiak, NL and Andersen, KG and Blyden, SO and Bolay, F and Carroll, MW and },
doi = {10.1038/nature22040},
journal = {Nature},
pages = {309--315},
title = {Virus genomes reveal factors that spread and sustained the Ebola epidemic},
url = {http://dx.doi.org/10.1038/nature22040},
volume = {544},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The 2013–2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic ‘gravity’ model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics.
AU  - Dudas,G
AU  - Carvalho,LM
AU  - Bedford,T
AU  - Tatem,AJ
AU  - Baele,G
AU  - Faria,NR
AU  - Park,DJ
AU  - Ladner,JT
AU  - Arias,A
AU  - Asogun,D
AU  - Bielejec,F
AU  - Caddy,SL
AU  - Cotten,M
AU  - D'Ambrozio,J
AU  - Dellicour,S
AU  - Di,Caro A
AU  - Diclaro,JW
AU  - Duraffour,S
AU  - Elmore,MJ
AU  - Iii,LSF
AU  - Faye,O
AU  - Gilbert,ML
AU  - Gevao,SM
AU  - Gire,S
AU  - Gladden-Young,A
AU  - Gnirke,A
AU  - Goba,A
AU  - Grant,DS
AU  - Haagmans,BL
AU  - Hiscox,JA
AU  - Jah,U
AU  - Kugelman,JR
AU  - Liu,D
AU  - Lu,J
AU  - Malboeuf,CM
AU  - Mate,S
AU  - Matthews,DA
AU  - Matranga,CB
AU  - Meredith,LW
AU  - Qu,J
AU  - Quick,J
AU  - Pas,SD
AU  - Phan,MVT
AU  - Pollakis,G
AU  - Reusken,CB
AU  - Sanchez-Lockhart,M
AU  - Schaffner,SF
AU  - Schieffelin,JS
AU  - Sealfon,RS
AU  - Simon-Loriere,E
AU  - Smits,SL
AU  - Stoecker,K
AU  - Thorne,L
AU  - Tobin,EA
AU  - Vandi,MA
AU  - Watson,SJ
AU  - West,K
AU  - Whitmer,S
AU  - Wiley,MR
AU  - Winnicki,SM
AU  - Wohl,S
AU  - Wolfel,R
AU  - Yozwiak,NL
AU  - Andersen,KG
AU  - Blyden,SO
AU  - Bolay,F
AU  - Carroll,MW
AU  - Dahn,B
AU  - Diallo,B
AU  - Formenty,P
AU  - Fraser,C
AU  - Gao,GF
AU  - Garry,RF
AU  - Goodfellow,I
AU  - Gnther,S
AU  - Happi,CT
AU  - Holmes,EC
AU  - Kargbo,B
AU  - Keita,S
AU  - Kellam,P
AU  - Koopmans,MPG
AU  - Kuhn,JH
AU  - Loman,NJ
AU  - Magassouba,N
AU  - Naidoo,D
AU  - Nichol,ST
AU  - Nyenswah,T
AU  - Palacios,G
AU  - Pybus,OG
AU  - Sabeti,PC
AU  - Sall,A
AU  - Stroher,U
AU  - Wurie,I
AU  - Suchard,MA
AU  - Lemey,P
AU  - Rambaut,A
DO  - 10.1038/nature22040
EP  - 315
PY  - 2017///
SN  - 0028-0836
SP  - 309
TI  - Virus genomes reveal factors that spread and sustained the Ebola epidemic
T2  - Nature
UR  - http://dx.doi.org/10.1038/nature22040
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000399524400029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/nature22040
UR  - http://hdl.handle.net/10044/1/84708
VL  - 544
ER  -
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