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@article{Croucher:2018:molbev/msx309,
author = {Croucher, NJ and Apagyi, KJ and Fraser, C},
doi = {molbev/msx309},
journal = {Molecular Biology and Evolution},
pages = {575--581},
title = {Transformation asymmetry and the evolution of the bacterial accessory genome},
url = {http://dx.doi.org/10.1093/molbev/msx309},
volume = {35},
year = {2018}
}

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TY  - JOUR
AB  - Bacterial transformation can insert or delete genomic islands (GIs), depending on the donor and recipient genotypes, if an homologous recombination spans the GI’s integration site and includes sufficiently long flanking homologous arms. Combining mathematical models of recombination with experiments using pneumococci found GI insertion rates declined geometrically with the GI’s size. The decrease in acquisition frequency with length (1.08x10−3 bp−1) was higher than a previous estimate of the analogous rate at which core genome recombinations terminated. Although most efficient for shorter GIs, transformation-mediated deletion frequencies did not vary consistently with GI length, with removal of 10 kb GIs approximately 50% as efficient as acquisition of base substitutions. Fragments of two kilobases, typical of transformation event sizes, could drive all these deletions independent of island length. The strong asymmetry of transformation, and its capacity to efficiently remove GIs, suggests non-mobile accessory loci will decline in frequency without preservation by selection.
AU  - Croucher,NJ
AU  - Apagyi,KJ
AU  - Fraser,C
DO  - molbev/msx309
EP  - 581
PY  - 2018///
SN  - 1537-1719
SP  - 575
TI  - Transformation asymmetry and the evolution of the bacterial accessory genome
T2  - Molecular Biology and Evolution
UR  - http://dx.doi.org/10.1093/molbev/msx309
UR  - http://hdl.handle.net/10044/1/54366
VL  - 35
ER  -

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