Imperial College London

DrClaireHiggins

Faculty of EngineeringDepartment of Bioengineering

Lecturer
 
 
 
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Contact

 

c.higgins Website

 
 
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Location

 

RSM 3.09Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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24 results found

Higgins CA, Roger MF, Hill RP, Ali-Khan AS, Garlick JA, Christiano AM, Jahoda CABet al., 2017, Multifaceted role of hair follicle dermal cells in bioengineered skins, BRITISH JOURNAL OF DERMATOLOGY, Vol: 176, Pages: 1259-1269, ISSN: 0007-0963

JOURNAL ARTICLE

Kiani MT, Higgins CA, Almquist BD, 2017, The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine, ACS Biomaterials Science & Engineering, ISSN: 2373-9878

JOURNAL ARTICLE

Logan NJ, Arora H, Higgins CA, 2017, Evaluating Primary Blast Effects In Vitro., J Vis Exp

Exposure to blast events can cause severe trauma to vital organs such as the lungs, ears, and brain. Understanding the mechanisms behind such blast-induced injuries is of great importance considering the recent trend towards the use of explosives in modern warfare and terrorist-related incidents. To fully understand blast-induced injury, we must first be able to replicate such blast events in a controlled environment using a reproducible method. In this technique using shock tube equipment, shock waves at a range of pressures can be propagated over live cells grown in 2D, and markers of cell viability can be immediately analyzed using a redox indicator assay and the fluorescent imaging of live and dead cells. This method demonstrated that increasing the peak blast overpressure to 127 kPa can stimulate a significant drop in cell viability when compared to untreated controls. Test samples are not limited to adherent cells, but can include cell suspensions, whole-body and tissue samples, through minor modifications to the shock tube setup. Replicating the exact conditions that tissues and cells experience when exposed to a genuine blast event is difficult. Techniques such as the one presented in this article can help to define damage thresholds and identify the transcriptional and epigenetic changes within cells that arise from shock wave exposure.

JOURNAL ARTICLE

Topouzi H, Logan NJ, Williams G, Higgins CAet al., 2017, Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles, EXPERIMENTAL DERMATOLOGY, Vol: 26, Pages: 491-496, ISSN: 0906-6705

JOURNAL ARTICLE

Topouzi H, Higgins CA, 2016, Changing faces: can a new identity stop balding?, EXPERIMENTAL DERMATOLOGY, Vol: 25, Pages: 765-766, ISSN: 0906-6705

JOURNAL ARTICLE

Gledhill K, Guo Z, Umegaki-Arao N, Higgins CA, Itoh M, Christiano AMet al., 2015, Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Harel S, Higgins CA, Cerise JE, Dai Z, Chen JC, Clynes R, Christiano AMet al., 2015, Pharmacologic inhibition of JAK-STAT signaling promotes hair growth, SCIENCE ADVANCES, Vol: 1, ISSN: 2375-2548

JOURNAL ARTICLE

Topouzi H, Higgins CA, 2015, Expression map of three distinct skin fibroblast populations isolated from human skin, 45th Annual Meeting of the European-Society-for-Dermatological-Research, Publisher: NATURE PUBLISHING GROUP, Pages: S68-S68, ISSN: 0022-202X

CONFERENCE PAPER

Eungdamrong NJ, Higgins C, Guo Z, Lee W-H, Gillette B, Sia S, Christiano AMet al., 2014, Challenges and promises in modeling dermatologic disorders with bioengineered skin, Experimental Biology and Medicine, Vol: 239, Pages: 1215-1224, ISSN: 1535-3702

JOURNAL ARTICLE

Furniss M, Higgins CA, Martinez-Mir A, Horev L, Petukhova L, Stanimirovic A, Miljkovic J, Zlotogorski A, Christiano AMet al., 2014, Identification of Distinct Mutations in AAGAB in Families with Type 1 Punctate Palmoplantar Keratoderma, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 134, Pages: 1749-1752, ISSN: 0022-202X

JOURNAL ARTICLE

Higgins CA, 2014, Interrogating the integument: the role of the epidermis in hair induction, EXPERIMENTAL DERMATOLOGY, Vol: 23, Pages: 714-715, ISSN: 0906-6705

JOURNAL ARTICLE

Higgins CA, Christiano AM, 2014, Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia, REGENERATIVE MEDICINE, Vol: 9, Pages: 101-111, ISSN: 1746-0751

JOURNAL ARTICLE

Higgins CA, Petukhova L, Harel S, Ho YY, Drill E, Shapiro L, Wajid M, Christiano AMet al., 2014, FGF5 is a crucial regulator of hair length in humans, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 10648-10653, ISSN: 0027-8424

JOURNAL ARTICLE

Xing L, Dai Z, Jabbari A, Cerise JE, Higgins CA, Gong W, de Jong A, Harel S, DeStefano GM, Rothman L, Singh P, Petukhova L, Mackay-Wiggan J, Christiano AM, Clynes Ret al., 2014, Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition, NATURE MEDICINE, Vol: 20, Pages: 1043-1049, ISSN: 1078-8956

JOURNAL ARTICLE

Guo Z, Higgins CA, Gillette BM, Itoh M, Umegaki N, Gledhill K, Sia SK, Christiano AMet al., 2013, Building a microphysiological skin model from induced pluripotent stem cells, STEM CELL RESEARCH & THERAPY, Vol: 4, ISSN: 1757-6512

JOURNAL ARTICLE

Higgins CA, Chen JC, Cerise JE, Jahoda CAB, Christiano AMet al., 2013, Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 19679-19688, ISSN: 0027-8424

JOURNAL ARTICLE

Itoh M, Umegaki-Arao N, Guo Z, Liu L, Higgins CA, Christiano AMet al., 2013, Generation of 3D Skin Equivalents Fully Reconstituted from Human Induced Pluripotent Stem Cells (iPSCs), PLOS ONE, Vol: 8, ISSN: 1932-6203

JOURNAL ARTICLE

De Berker D, Higgins CA, Jahoda C, Christiano AMet al., 2012, Biology of Hair and Nails, Dermatology, 3rd Edition, Editors: Bolognia, Jorizzo, Schaffer, Publisher: Elsevier Publishing, ISBN: 9780723435716

Better comprehend the clinical-pathological relationship of skin disease with increased histologic coverage. Bolognia's Dermatology is the ultimate multimedia reference for residents in training AND the experienced practitioner.

BOOK CHAPTER

Higgins CA, Itoh M, Inoue K, Richardson GD, Jahoda CAB, Christiano AMet al., 2012, Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 132, Pages: 1725-1727, ISSN: 0022-202X

JOURNAL ARTICLE

Hill RP, Gledhill K, Gardner A, Higgins CA, Crawford H, Lawrence C, Hutchison CJ, Owens WA, Kara B, James SE, Jahoda CABet al., 2012, Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures, PLOS ONE, Vol: 7, ISSN: 1932-6203

JOURNAL ARTICLE

Higgins CA, Westgate GE, Jahoda CAB, 2011, Modulation in Proteolytic Activity Is Identified as a Hallmark of Exogen by Transcriptional Profiling of Hair Follicles, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 131, Pages: 2349-2357, ISSN: 0022-202X

JOURNAL ARTICLE

Higgins CA, Richardson GD, Ferdinando D, Westgate GE, Jahoda CABet al., 2010, Modelling the hair follicle dermal papilla using spheroid cell cultures, EXPERIMENTAL DERMATOLOGY, Vol: 19, Pages: 546-548, ISSN: 0906-6705

JOURNAL ARTICLE

Higgins CA, Richardson GD, Westgate GE, Jahoda CABet al., 2009, Exogen involves gradual release of the hair club fibre in the vibrissa follicle model, EXPERIMENTAL DERMATOLOGY, Vol: 18, Pages: 793-795, ISSN: 0906-6705

JOURNAL ARTICLE

Higgins CA, Westgate GE, Jahoda CAB, 2009, From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 129, Pages: 2100-2108, ISSN: 0022-202X

JOURNAL ARTICLE

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