Publications

BibTex format

@article{Harel:2015:10.1126/sciadv.1500973,
author = {Harel, S and Higgins, CA and Cerise, JE and Dai, Z and Chen, JC and Clynes, R and Christiano, AM},
doi = {10.1126/sciadv.1500973},
journal = {Science Advances},
title = {Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.},
url = {http://dx.doi.org/10.1126/sciadv.1500973},
volume = {1},
year = {2015}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being arrested in the resting phase (telogen). Current pharmacologic therapies have been largely unsuccessful in targeting pathways that can be selectively modulated to induce entry into anagen. We show that topical treatment of mouse and human skin with small-molecule inhibitors of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway results in rapid onset of anagen and subsequent hair growth. We show that JAK inhibition regulates the activation of key hair follicle populations such as the hair germ and improves the inductivity of cultured human dermal papilla cells by controlling a molecular signature enriched in intact, fully inductive dermal papillae. Our findings open new avenues for exploration of JAK-STAT inhibition for promotion of hair growth and highlight the role of this pathway in regulating the activation of hair follicle stem cells.
AU  - Harel,S
AU  - Higgins,CA
AU  - Cerise,JE
AU  - Dai,Z
AU  - Chen,JC
AU  - Clynes,R
AU  - Christiano,AM
DO  - 10.1126/sciadv.1500973
PY  - 2015///
SN  - 2375-2548
TI  - Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.1500973
UR  - http://hdl.handle.net/10044/1/28658
VL  - 1
ER  -

Download

DrClaireHiggins

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)