Imperial College London

Dr. Channa Jayasena MA PhD MRCP FRCPath

Faculty of MedicineDepartment of Medicine

Clinical Senior Lecturer in Endocrinology
 
 
 
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Contact

 

c.jayasena Website

 
 
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Location

 

6N5CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

97 results found

Jayasena CN, Alkaabi FM, Liebers CS, Handley T, Franks S, Dhillo WSet al., 2019, A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women, CLINICAL ENDOCRINOLOGY, Vol: 90, Pages: 391-414, ISSN: 0300-0664

JOURNAL ARTICLE

Jayasena CN, Radia UK, Figueiredo M, Revill LF, Dimakopoulou A, Osagie M, Vessey W, Regan L, Rai R, Dhillo WSet al., 2019, Reduced Testicular Steroidogenesis and Increased Semen Oxidative Stress in Male Partners as Novel Markers of Recurrent Miscarriage, CLINICAL CHEMISTRY, Vol: 65, Pages: 161-169, ISSN: 0009-9147

JOURNAL ARTICLE

Miah S, Tharakan T, Gallagher KA, Shah TT, Winkler M, Jayasena CN, Ahmed HU, Minhas Set al., 2019, The effects of testosterone replacement therapy on the prostate: a clinical perspective., F1000Res, Vol: 8

Male hypogonadism is a clinical syndrome characterized by low testosterone and symptoms of androgen deficiency. Prostate cancer remains a significant health burden and cause of male mortality worldwide. The use of testosterone replacement therapy drugs is rising year-on-year for the treatment of androgen deficiency and has reached global proportions. As clinicians, we must be well versed and provide appropriate counseling for men prior to the commencement of testosterone replacement therapy. This review summarizes the current clinical and basic science evidence in relation to this commonly encountered clinical scenario. There is gathering evidence that suggests, from an oncological perspective, that it is safe to commence testosterone replacement therapy for men who have a combination of biochemically confirmed androgen deficiency and who have either had definitive treatment of their prostate cancer or no previous history of this disease. However, patients must be made aware and cautioned that there is a distinct lack of level 1 evidence. Calls for such studies have been made throughout the urological and andrological community to provide a definitive answer. For those with a diagnosis of prostate cancer that remains untreated, there is a sparsity of evidence and therefore clinicians are "pushing the limits" of safety when considering the commencement of testosterone replacement therapy.

JOURNAL ARTICLE

Rose AM, Luo R, Radia UK, Kalirai H, Thornton S, Luthert PJ, Jayasena CN, Verity DH, Coupland SE, Rose GEet al., 2018, Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis, BMC CANCER, Vol: 18, ISSN: 1471-2407

JOURNAL ARTICLE

Jayasena CN, Luo R, Dimakopoulou A, Dearing C, Clarke H, Patel N, Stroud T, Seyani L, Ramsay J, Dhillo WSet al., 2018, Prevalence of abnormal semen analysis and levels of adherence with fertility preservation in men undergoing therapy for newly diagnosed cancer: A retrospective study in 2906 patients, CLINICAL ENDOCRINOLOGY, Vol: 89, Pages: 798-804, ISSN: 0300-0664

JOURNAL ARTICLE

Comninos AN, Demetriou L, Wall MB, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Yang L, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, McGonigle J, Rabiner EA, Bloom SR, Dhillo WSet al., 2018, Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions, JCI INSIGHT, Vol: 3, ISSN: 2379-3708

JOURNAL ARTICLE

Wall J, Jayasena CN, 2018, Diagnosing male infertility, BMJ-BRITISH MEDICAL JOURNAL, Vol: 363, ISSN: 1756-1833

JOURNAL ARTICLE

Prague JK, Roberts RE, Comninos AN, Clarke S, Jayasena CN, Mohideen P, Lin VH, Stern TP, Panay N, Hunter MS, Webber LC, Dhillo WSet al., 2018, Neurokinin 3 receptor antagonism rapidly improves vasomotor symptoms with sustained duration of action, MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol: 25, Pages: 862-869, ISSN: 1072-3714

JOURNAL ARTICLE

Dimakopoulou A, Jayasena CN, 2018, Seminal reactive oxygen species, a novel biochemical assay for testing male fertility?, Biochemist, Vol: 40, Pages: 12-13, ISSN: 0954-982X

© Biochemical Society. Infertility is defined as a failure to achieve a positive pregnancy test over 12 months of regular unprotected sex. It is a devastating condition affecting 15% of couples and is socially marginalizing. Despite significant focus on the female, nearly half of cases are in fact due to poor sperm function in the male partner. It is therefore surprising that despite the existence of numerous diagnostic tools and management options currently available for female infertility, very few exist for their male counterparts. So, what can we do to diagnose men with impaired fertility promptly and direct couples to effective management strategies?.

JOURNAL ARTICLE

Rose AM, Radia UK, Luo R, Kalirai H, Jayasena CN, Luthert P, Coupland SE, Rose GEet al., 2018, Multiple primary malignancies and prolonged survival in a patient with widespread metastatic cutaneous melanoma, MELANOMA RESEARCH, Vol: 28, Pages: 163-166, ISSN: 0960-8931

JOURNAL ARTICLE

Ali SN, Jayasena CN, Sam AH, 2018, Which patients with gynaecomastia require more detailed investigation?, CLINICAL ENDOCRINOLOGY, Vol: 88, Pages: 360-363, ISSN: 0300-0664

JOURNAL ARTICLE

Algeffari M, Jayasena CN, MacKeith P, Thapar A, Dhillo WS, Oliver Net al., 2018, Testosterone therapy for sexual dysfunction in men with Type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials, DIABETIC MEDICINE, Vol: 35, Pages: 195-202, ISSN: 0742-3071

JOURNAL ARTICLE

de Tassigny XD, Jayasena CN, Murphy KG, Dhillo WS, Colledge WHet al., 2018, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo (vol 12, e0176821, 2017), PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Abbara A, Narayanaswamy S, Izzi-Engbeaya C, Comninos AN, Clarke SA, Malik Z, Papadopoulou D, Clobentz A, Sarang Z, Bassett P, Jayasena CN, Dhillo WSet al., 2018, Hypothalamic Response to Kisspeptin-54 and Pituitary Response to Gonadotropin-Releasing Hormone Are Preserved in Healthy Older Men, NEUROENDOCRINOLOGY, Vol: 106, Pages: 401-410, ISSN: 0028-3835

JOURNAL ARTICLE

Rose AM, Luthert PJ, Jayasena CN, Verity DH, Rose GEet al., 2017, Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients, FRONTIERS IN ONCOLOGY, Vol: 7, ISSN: 2234-943X

JOURNAL ARTICLE

Dearing CG, Jayasena CN, Lindsay KS, 2017, Human sperm cryopreservation in cancer patients: Links with deprivation and mortality, CRYOBIOLOGY, Vol: 79, Pages: 9-13, ISSN: 0011-2240

JOURNAL ARTICLE

Prague JK, Roberts RE, Comninos AN, Clarke S, Jayasena CN, Nash Z, Doyle C, Papadopoulou D, Bloom SR, Mohideen P, Lin V, Stern T, Panay N, Hunter MS, Veldhuis JD, Webber LC, Huson L, Dhillo WSet al., 2017, Neurokinin 3 receptor antagonism is a highly effective, novel treatment for menopausal hot flushes with rapid onset: a phase 2, randomised, double-blind, placebo-controlled trial, 28th Annual Meeting of the North-American-Menopause-Society, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1429-1430, ISSN: 1072-3714

CONFERENCE PAPER

Lal V, Jayasena CN, Quinton R, 2017, The emergence of sarcopenia as an important entity in older people, CLINICAL MEDICINE, Vol: 17, Pages: 590-590, ISSN: 1470-2118

JOURNAL ARTICLE

Rozati H, Handley T, Jayasena CN, 2017, Process and Pitfalls of Sperm Cryopreservation., J Clin Med, Vol: 6, ISSN: 2077-0383

Sperm cryopreservation has been utilized routinely for over 40 years to preserve fertility in men undergoing cancer therapy and allow conception for infertile couples. This article provides a concise and up-to-date review of the literature and covers the latest advances in sperm cryopreservation and its array of clinical indications. Over recent years, the scope of clinical indications used for sperm cryopreservation has expanded widely. Consequently, more patient groups are eligible for sperm freezing, requiring specialist resources and higher running costs. Although sperm cryopreservation prior to cancer therapy is readily available in many countries, referral rates by oncology specialists and levels of patient engagement with cryopreservation services are both reported as low. Furthermore, sperm banking continues to raise ethical issues such whether sperm donation should be anonymous and whether sperm can be utilized posthumously by the surviving partner without consent from the patient. This review focuses on the technological advances and ethical controversies in sperm cryopreservation, and how better understanding of these issues could lead to improved access to fertility preserving treatment for patients.

JOURNAL ARTICLE

Wernig F, Jayasena CN, Dhillo WS, 2017, Carcinoid syndrome and neuroendocrine tumours, Medicine (United Kingdom), Vol: 45, Pages: 543-546, ISSN: 1357-3039

© 2017 Neuroendocrine tumours (NETs) arise from the gastrointestinal tract, pancreas, bronchi or other rare primary sites and comprise a variety of different tumour types. Carcinoid tumours are the most common. NETs can be associated with a variety of clinical syndromes. For instance, classic symptoms of carcinoid syndrome, such as flushing and diarrhoea, occur because of the release of hormones, including serotonin, tachykinins and peptide hormones. However, most NETs are non-secretory in nature and are detected incidentally or through compression of surrounding structures. Liver metastasis has usually already occurred at the time of diagnosis. Surgery can be curative if disease is entirely localized. Injections of somatostatin analogues such as octreotide are the mainstay of non-surgical treatment for NETs. Surgical debulking and embolization techniques are useful to reduce tumour bulk in patients who remain symptomatic despite medical treatment. Peptide receptor radionucleotide therapy using radiolabelled somatostatin analogues has recently been shown to prolong progression-free survival. Furthermore, several novel agents, such as everolimus, have emerged in the treatment of patients with metastatic disease. This article aims to summarize the pathophysiology and clinical features of NETs, with a focus on carcinoid syndrome. It also discusses recent advances in clinical management of NETs.

JOURNAL ARTICLE

Rose AM, Cowen S, Jayasena CN, Verity DH, Rose GEet al., 2017, Presentation, Treatment, and Prognosis of secondary Melanoma within the Orbit, FRONTIERS IN ONCOLOGY, Vol: 7, ISSN: 2234-943X

JOURNAL ARTICLE

Prague JK, Roberts RE, Comninos AN, Clarke S, Jayasena CN, Nash Z, Doyle C, Papadopoulou DA, Bloom SR, Mohideen P, Panay N, Hunter MS, Veldhuis JD, Webber LC, Huson L, Dhillo WSet al., 2017, Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial, LANCET, Vol: 389, Pages: 1809-1820, ISSN: 0140-6736

JOURNAL ARTICLE

de Tassigny XD, Jayasena C, Murphy KG, Dhillo WS, Colledge WHet al., 2017, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo, PLOS ONE, Vol: 12, ISSN: 1932-6203

JOURNAL ARTICLE

Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, Rabiner EA, Honigsperger C, Silva MR, Brandtzaeg OK, Lundanes E, Wilson SR, Brown RC, Thomas SA, Bloom SR, Dhillo WSet al., 2017, Kisspeptin modulates sexual and emotional brain processing in humans, JOURNAL OF CLINICAL INVESTIGATION, Vol: 127, Pages: 709-719, ISSN: 0021-9738

JOURNAL ARTICLE

Quinton R, Mamoojee Y, Jayasena CN, Young J, Howard S, Dunkel L, Cheetham T, Smith N, Dwyer AAet al., 2017, Society for Endocrinology UK guidance on the evaluation of suspected disorders of sexual development: emphasizing the opportunity to predict adolescent pubertal failure through a neonatal diagnosis of absent minipuberty, CLINICAL ENDOCRINOLOGY, Vol: 86, Pages: 305-306, ISSN: 0300-0664

JOURNAL ARTICLE

Jayasena CN, Abbara A, Comninos AN, Narayanaswamy S, Maffe JG, Izzi-Engbeaya C, Oldham J, Lee TTM, Sarang Z, Malik Z, Dhanjal MK, Williamson C, Regan L, Bloom SR, Dhillo WSet al., 2016, Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and association with late miscarriage, HUMAN REPRODUCTION, Vol: 31, Pages: 2681-2688, ISSN: 0268-1161

JOURNAL ARTICLE

Narayanaswamy S, Prague JK, Jayasena CN, Papadopoulou DA, Mizamtsidi M, Shah AJ, Bassett P, Comninos AN, Abbara A, Bloom SR, Veldhuis JD, Dhillo WSet al., 2016, Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 101, Pages: 3429-3436, ISSN: 0021-972X

JOURNAL ARTICLE

Narayanaswamy S, Jayasena CN, Ng N, Ratnasabapathy R, Prague JK, Papadopoulou D, Abbara A, Comninos AN, Bassett P, Bloom SR, Veldhuis JD, Dhillo WSet al., 2016, Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels, CLINICAL ENDOCRINOLOGY, Vol: 84, Pages: 939-945, ISSN: 0300-0664

JOURNAL ARTICLE

Dwyer AA, Jayasena CN, Quinton R, 2016, Congenital hypogonadotropic hypogonadism: implications of absent mini-puberty, MINERVA ENDOCRINOLOGICA, Vol: 41, Pages: 188-195, ISSN: 0391-1977

JOURNAL ARTICLE

Thomas J, Radia U, Ramsay J, Jayasena CNet al., 2016, Microdissection testicular sperm extraction for men undergoing cancer treatment, Expert Review of Quality of Life in Cancer Care, Vol: 1, Pages: 207-212

JOURNAL ARTICLE

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