97 results found
Jayasena CN, Alkaabi FM, Liebers CS, et al., 2019, A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women, CLINICAL ENDOCRINOLOGY, Vol: 90, Pages: 391-414, ISSN: 0300-0664
Jayasena CN, Radia UK, Figueiredo M, et al., 2019, Reduced Testicular Steroidogenesis and Increased Semen Oxidative Stress in Male Partners as Novel Markers of Recurrent Miscarriage, CLINICAL CHEMISTRY, Vol: 65, Pages: 161-169, ISSN: 0009-9147
Miah S, Tharakan T, Gallagher KA, et al., 2019, The effects of testosterone replacement therapy on the prostate: a clinical perspective., F1000Res, Vol: 8
Male hypogonadism is a clinical syndrome characterized by low testosterone and symptoms of androgen deficiency. Prostate cancer remains a significant health burden and cause of male mortality worldwide. The use of testosterone replacement therapy drugs is rising year-on-year for the treatment of androgen deficiency and has reached global proportions. As clinicians, we must be well versed and provide appropriate counseling for men prior to the commencement of testosterone replacement therapy. This review summarizes the current clinical and basic science evidence in relation to this commonly encountered clinical scenario. There is gathering evidence that suggests, from an oncological perspective, that it is safe to commence testosterone replacement therapy for men who have a combination of biochemically confirmed androgen deficiency and who have either had definitive treatment of their prostate cancer or no previous history of this disease. However, patients must be made aware and cautioned that there is a distinct lack of level 1 evidence. Calls for such studies have been made throughout the urological and andrological community to provide a definitive answer. For those with a diagnosis of prostate cancer that remains untreated, there is a sparsity of evidence and therefore clinicians are "pushing the limits" of safety when considering the commencement of testosterone replacement therapy.
Rose AM, Luo R, Radia UK, et al., 2018, Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis, BMC CANCER, Vol: 18, ISSN: 1471-2407
Jayasena CN, Luo R, Dimakopoulou A, et al., 2018, Prevalence of abnormal semen analysis and levels of adherence with fertility preservation in men undergoing therapy for newly diagnosed cancer: A retrospective study in 2906 patients, CLINICAL ENDOCRINOLOGY, Vol: 89, Pages: 798-804, ISSN: 0300-0664
Comninos AN, Demetriou L, Wall MB, et al., 2018, Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions, JCI INSIGHT, Vol: 3, ISSN: 2379-3708
Wall J, Jayasena CN, 2018, Diagnosing male infertility, BMJ-BRITISH MEDICAL JOURNAL, Vol: 363, ISSN: 1756-1833
Prague JK, Roberts RE, Comninos AN, et al., 2018, Neurokinin 3 receptor antagonism rapidly improves vasomotor symptoms with sustained duration of action, MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol: 25, Pages: 862-869, ISSN: 1072-3714
Dimakopoulou A, Jayasena CN, 2018, Seminal reactive oxygen species, a novel biochemical assay for testing male fertility?, Biochemist, Vol: 40, Pages: 12-13, ISSN: 0954-982X
© Biochemical Society. Infertility is defined as a failure to achieve a positive pregnancy test over 12 months of regular unprotected sex. It is a devastating condition affecting 15% of couples and is socially marginalizing. Despite significant focus on the female, nearly half of cases are in fact due to poor sperm function in the male partner. It is therefore surprising that despite the existence of numerous diagnostic tools and management options currently available for female infertility, very few exist for their male counterparts. So, what can we do to diagnose men with impaired fertility promptly and direct couples to effective management strategies?.
Rose AM, Radia UK, Luo R, et al., 2018, Multiple primary malignancies and prolonged survival in a patient with widespread metastatic cutaneous melanoma, MELANOMA RESEARCH, Vol: 28, Pages: 163-166, ISSN: 0960-8931
Ali SN, Jayasena CN, Sam AH, 2018, Which patients with gynaecomastia require more detailed investigation?, CLINICAL ENDOCRINOLOGY, Vol: 88, Pages: 360-363, ISSN: 0300-0664
Algeffari M, Jayasena CN, MacKeith P, et al., 2018, Testosterone therapy for sexual dysfunction in men with Type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials, DIABETIC MEDICINE, Vol: 35, Pages: 195-202, ISSN: 0742-3071
de Tassigny XD, Jayasena CN, Murphy KG, et al., 2018, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo (vol 12, e0176821, 2017), PLOS ONE, Vol: 13, ISSN: 1932-6203
Abbara A, Narayanaswamy S, Izzi-Engbeaya C, et al., 2018, Hypothalamic Response to Kisspeptin-54 and Pituitary Response to Gonadotropin-Releasing Hormone Are Preserved in Healthy Older Men, NEUROENDOCRINOLOGY, Vol: 106, Pages: 401-410, ISSN: 0028-3835
Rose AM, Luthert PJ, Jayasena CN, et al., 2017, Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients, FRONTIERS IN ONCOLOGY, Vol: 7, ISSN: 2234-943X
Dearing CG, Jayasena CN, Lindsay KS, 2017, Human sperm cryopreservation in cancer patients: Links with deprivation and mortality, CRYOBIOLOGY, Vol: 79, Pages: 9-13, ISSN: 0011-2240
Prague JK, Roberts RE, Comninos AN, et al., 2017, Neurokinin 3 receptor antagonism is a highly effective, novel treatment for menopausal hot flushes with rapid onset: a phase 2, randomised, double-blind, placebo-controlled trial, 28th Annual Meeting of the North-American-Menopause-Society, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1429-1430, ISSN: 1072-3714
Lal V, Jayasena CN, Quinton R, 2017, The emergence of sarcopenia as an important entity in older people, CLINICAL MEDICINE, Vol: 17, Pages: 590-590, ISSN: 1470-2118
Rozati H, Handley T, Jayasena CN, 2017, Process and Pitfalls of Sperm Cryopreservation., J Clin Med, Vol: 6, ISSN: 2077-0383
Sperm cryopreservation has been utilized routinely for over 40 years to preserve fertility in men undergoing cancer therapy and allow conception for infertile couples. This article provides a concise and up-to-date review of the literature and covers the latest advances in sperm cryopreservation and its array of clinical indications. Over recent years, the scope of clinical indications used for sperm cryopreservation has expanded widely. Consequently, more patient groups are eligible for sperm freezing, requiring specialist resources and higher running costs. Although sperm cryopreservation prior to cancer therapy is readily available in many countries, referral rates by oncology specialists and levels of patient engagement with cryopreservation services are both reported as low. Furthermore, sperm banking continues to raise ethical issues such whether sperm donation should be anonymous and whether sperm can be utilized posthumously by the surviving partner without consent from the patient. This review focuses on the technological advances and ethical controversies in sperm cryopreservation, and how better understanding of these issues could lead to improved access to fertility preserving treatment for patients.
Wernig F, Jayasena CN, Dhillo WS, 2017, Carcinoid syndrome and neuroendocrine tumours, Medicine (United Kingdom), Vol: 45, Pages: 543-546, ISSN: 1357-3039
© 2017 Neuroendocrine tumours (NETs) arise from the gastrointestinal tract, pancreas, bronchi or other rare primary sites and comprise a variety of different tumour types. Carcinoid tumours are the most common. NETs can be associated with a variety of clinical syndromes. For instance, classic symptoms of carcinoid syndrome, such as flushing and diarrhoea, occur because of the release of hormones, including serotonin, tachykinins and peptide hormones. However, most NETs are non-secretory in nature and are detected incidentally or through compression of surrounding structures. Liver metastasis has usually already occurred at the time of diagnosis. Surgery can be curative if disease is entirely localized. Injections of somatostatin analogues such as octreotide are the mainstay of non-surgical treatment for NETs. Surgical debulking and embolization techniques are useful to reduce tumour bulk in patients who remain symptomatic despite medical treatment. Peptide receptor radionucleotide therapy using radiolabelled somatostatin analogues has recently been shown to prolong progression-free survival. Furthermore, several novel agents, such as everolimus, have emerged in the treatment of patients with metastatic disease. This article aims to summarize the pathophysiology and clinical features of NETs, with a focus on carcinoid syndrome. It also discusses recent advances in clinical management of NETs.
Rose AM, Cowen S, Jayasena CN, et al., 2017, Presentation, Treatment, and Prognosis of secondary Melanoma within the Orbit, FRONTIERS IN ONCOLOGY, Vol: 7, ISSN: 2234-943X
Prague JK, Roberts RE, Comninos AN, et al., 2017, Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial, LANCET, Vol: 389, Pages: 1809-1820, ISSN: 0140-6736
de Tassigny XD, Jayasena C, Murphy KG, et al., 2017, Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo, PLOS ONE, Vol: 12, ISSN: 1932-6203
Comninos AN, Wall MB, Demetriou L, et al., 2017, Kisspeptin modulates sexual and emotional brain processing in humans, JOURNAL OF CLINICAL INVESTIGATION, Vol: 127, Pages: 709-719, ISSN: 0021-9738
Quinton R, Mamoojee Y, Jayasena CN, et al., 2017, Society for Endocrinology UK guidance on the evaluation of suspected disorders of sexual development: emphasizing the opportunity to predict adolescent pubertal failure through a neonatal diagnosis of absent minipuberty, CLINICAL ENDOCRINOLOGY, Vol: 86, Pages: 305-306, ISSN: 0300-0664
Jayasena CN, Abbara A, Comninos AN, et al., 2016, Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and association with late miscarriage, HUMAN REPRODUCTION, Vol: 31, Pages: 2681-2688, ISSN: 0268-1161
Narayanaswamy S, Prague JK, Jayasena CN, et al., 2016, Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 101, Pages: 3429-3436, ISSN: 0021-972X
Narayanaswamy S, Jayasena CN, Ng N, et al., 2016, Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels, CLINICAL ENDOCRINOLOGY, Vol: 84, Pages: 939-945, ISSN: 0300-0664
Dwyer AA, Jayasena CN, Quinton R, 2016, Congenital hypogonadotropic hypogonadism: implications of absent mini-puberty, MINERVA ENDOCRINOLOGICA, Vol: 41, Pages: 188-195, ISSN: 0391-1977
Thomas J, Radia U, Ramsay J, et al., 2016, Microdissection testicular sperm extraction for men undergoing cancer treatment, Expert Review of Quality of Life in Cancer Care, Vol: 1, Pages: 207-212
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