Imperial College London
Alternate

Dr. Channa Jayasena MA PhD MRCP FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Reproductive Endocrinology
 
 
 
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Contact

 

c.jayasena Website

 
 
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Location

 

6N5CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dearing:2019:10.1080/14647273.2019.1610581,
author = {Dearing, C and Jayasena, C and Lindsay, K},
doi = {10.1080/14647273.2019.1610581},
journal = {Human Fertility},
pages = {208--218},
title = {Can the sperm class analyser (SCA) CASA-Mot system for human sperm motility analysis reduce imprecision and operator subjectivity and improve semen analysis?},
url = {http://dx.doi.org/10.1080/14647273.2019.1610581},
volume = {24},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Semen analysis (SA) is considered mandatory for suspected male infertility although its clinical value has recently become questionable. Sperm motility is an essential parameter for SA, but is limited by high measurement uncertainty, which includes operator subjectivity. Computer-assisted sperm analysis (CASA) can reduce measurement uncertainty compared with manual SA. The objective of this study was to determine whether the Sperm Class Analyser (SCA) CASA-Mot system could reduce specific components of sperm motility measurement uncertainty compared with the World Health Organization (WHO) manual method in a single laboratory undertaking routine diagnostic SA. The study examined: (i) operator subjectivity; (ii) precision, (iii) accuracy against internal and external quality standards; and (iv) a pilot sub-study examining the potential to predict an IVF fertilisation rate. Compared with the manual WHO method of SA on 4000 semen samples, SCA reduces but does not completely eliminate operator subjectivity. Study SCA and CASA-Mot are useful tools for well-trained staff that allow rapid, high-number sperm motility categorization with less analytical variance than the manual equivalent. Our initial data suggest that SCA motility may have superior predictive potential compared with the WHO manual method for predicating IVF fertilization.
AU  - Dearing,C
AU  - Jayasena,C
AU  - Lindsay,K
DO  - 10.1080/14647273.2019.1610581
EP  - 218
PY  - 2019///
SN  - 1464-7273
SP  - 208
TI  - Can the sperm class analyser (SCA) CASA-Mot system for human sperm motility analysis reduce imprecision and operator subjectivity and improve semen analysis?
T2  - Human Fertility
UR  - http://dx.doi.org/10.1080/14647273.2019.1610581
UR  - https://www.tandfonline.com/doi/full/10.1080/14647273.2019.1610581
UR  - http://hdl.handle.net/10044/1/71852
VL  - 24
ER  -
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