Imperial College London
Alternate

Dr. Channa Jayasena MA PhD MRCP FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Reproductive Endocrinology
 
 
 
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Contact

 

c.jayasena Website

 
 
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Location

 

6N5CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sharma:2020:10.3390/ijms21082958,
author = {Sharma, A and Thaventhiran, T and Minhas, S and Dhillo, WS and Jayasena, CN},
doi = {10.3390/ijms21082958},
journal = {International Journal of Molecular Sciences},
pages = {1--14},
title = {Kisspeptin and testicular function-is it necessary?},
url = {http://dx.doi.org/10.3390/ijms21082958},
volume = {21},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current literature investigating the distribution, regulation and effects of kisspeptin and its receptor (KISS1/KISS1R) within the testes of species studied to date. There is substantial evidence of localised KISS1/KISS1R expression and peptide distribution in the testes. However, variability is observed in the testicular cell types expressing KISS1/KISS1R. Evidence is presented for modulation of steroidogenesis and sperm function by kisspeptin signaling. However, the physiological importance of such effects, and whether these are paracrine or endocrine manifestations, remain unclear.
AU  - Sharma,A
AU  - Thaventhiran,T
AU  - Minhas,S
AU  - Dhillo,WS
AU  - Jayasena,CN
DO  - 10.3390/ijms21082958
EP  - 14
PY  - 2020///
SN  - 1422-0067
SP  - 1
TI  - Kisspeptin and testicular function-is it necessary?
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms21082958
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000535565300300&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/1422-0067/21/8/2958
UR  - http://hdl.handle.net/10044/1/85092
VL  - 21
ER  -
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