Imperial College London
Alternate

Dr. Channa Jayasena MA PhD MRCP FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Reproductive Endocrinology
 
 
 
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Contact

 

c.jayasena Website

 
 
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Location

 

6N5CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Comninos:2017:10.1172/JCI89519,
author = {Comninos, A and Wall, M and Demetriou, L and Shah, AJ and Clarke, S and Narayanaswamy, S and Nesbitt, A and Izzi-engbeaya, C and Prague, J and Abbara, A and Ratnasabapathy, R and Salem, V and Nijher, G and Jayasena, C and Tanner, M and Bassett, P and Mehta, A and Rabiner, E and Honigsperger, C and Silva, MR and Brandtzaeg, OK and Lundanes, E and Wilson, SR and Brown, RC and Thomas, SA and Bloom, SR and Dhillo, WS},
doi = {10.1172/JCI89519},
journal = {Journal of Clinical Investigation},
pages = {709--719},
title = {Kisspeptin modulates sexual and emotional brain processing in humans},
url = {http://dx.doi.org/10.1172/JCI89519},
volume = {127},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background. Sex, emotion, and reproduction are fundamental and tightly entwined aspects of human behaviour. At a population level in humans, both the desire for sexual stimulation and the desire to bond with a partner are important precursors to reproduction. However, the relationships between these processes are incompletely understood. The limbic brain system has key roles in sexual and emotional behaviours, and is a likely candidate system for the integration of behaviour with the hormonal reproductive axis. We investigated the effects of kisspeptin, a recently identified key reproductive hormone, on limbic brain activity and behaviour.Methods. Using a combination of hormonal, functional neuroimaging and psychometric analyses we compared the effects of kisspeptin versus vehicle administration in 29 healthy heterosexual young men.Results. We demonstrate that kisspeptin enhances limbic brain activity specifically in response to sexual and couple-bonding stimuli. Furthermore, kisspeptin’s enhancement of limbic brain structures correlated with psychometric measures of reward, drive, mood and sexual aversion providing functional significance. In addition, kisspeptin administration attenuated negative mood.Conclusion. Collectively, our data provide evidence of a novel role for kisspeptin in the integration of sexual and emotional brain processing with reproduction in humans, and have important implications for our understanding of reproductive biology highly relevant to the current pharmacological development of kisspeptin as a potential therapeutic agent for patients with common disorders of reproductive function.
AU  - Comninos,A
AU  - Wall,M
AU  - Demetriou,L
AU  - Shah,AJ
AU  - Clarke,S
AU  - Narayanaswamy,S
AU  - Nesbitt,A
AU  - Izzi-engbeaya,C
AU  - Prague,J
AU  - Abbara,A
AU  - Ratnasabapathy,R
AU  - Salem,V
AU  - Nijher,G
AU  - Jayasena,C
AU  - Tanner,M
AU  - Bassett,P
AU  - Mehta,A
AU  - Rabiner,E
AU  - Honigsperger,C
AU  - Silva,MR
AU  - Brandtzaeg,OK
AU  - Lundanes,E
AU  - Wilson,SR
AU  - Brown,RC
AU  - Thomas,SA
AU  - Bloom,SR
AU  - Dhillo,WS
DO  - 10.1172/JCI89519
EP  - 719
PY  - 2017///
SN  - 1558-8238
SP  - 709
TI  - Kisspeptin modulates sexual and emotional brain processing in humans
T2  - Journal of Clinical Investigation
UR  - http://dx.doi.org/10.1172/JCI89519
UR  - https://www.jci.org/articles/view/89519
UR  - http://hdl.handle.net/10044/1/42942
VL  - 127
ER  -
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