Imperial College London

DrChristopherJohn

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Pharmacology
 
 
 
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Contact

 

+44 (0)20 3313 8039c.john

 
 
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Location

 

6N5cCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

24 results found

Basharat S, Parker JA, Murphy KG, Bloom SR, Buckingham JC, John CDet al., 2014, Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary- adrenal axis in rats, Journal of Endocrinology, Vol: 221, Pages: 229-234, ISSN: 0022-0795

Obesity is a risk factor for sepsis morbidity and mortality, whereas the hypothalamic–pituitary–adrenal (HPA) axis plays a protective role in the body's defence against sepsis. Sepsis induces a profound systemic immune response and cytokines serve as excellent markers for sepsis as they act as mediators of the immune response. Evidence suggests that the adipokine leptin may play a pathogenic role in sepsis. Mouse endotoxaemic models present with elevated leptin levels and exogenously added leptin increased mortality whereas human septic patients have elevated circulating levels of the soluble leptin receptor (Ob-Re). Evidence suggests that leptin can inhibit the regulation of the HPA axis. Thus, leptin may suppress the HPA axis, impairing its protective role in sepsis. We hypothesised that leptin would attenuate the HPA axis response to sepsis. We investigated the direct effects of an i.p. injection of 2 mg/kg leptin on the HPA axis response to intraperitoneally injected 25 μg/kg lipopolysaccharide (LPS) in the male Wistar rat. We found that LPS potently activated the HPA axis, as shown by significantly increased plasma stress hormones, ACTH and corticosterone, and increased plasma interleukin 1β (IL1β) levels, 2 h after administration. Pre-treatment with leptin, 2 h before LPS administration, did not influence the HPA axis response to LPS. In turn, LPS did not affect plasma leptin levels. Our findings suggest that leptin does not influence HPA function or IL1β secretion in a rat model of LPS-induced sepsis, and thus that leptin is unlikely to be involved in the acute-phase endocrine response to bacterial infection in rats.

Journal article

Mehet DK, Philip J, Solito E, Buckingham JC, John CDet al., 2012, Evidence From In Vitro and In Vivo Studies Showing that Nuclear Factor-Kappa B Within the Pituitary Folliculostellate Cells and Corticotrophs Regulates Adrenocorticotrophic Hormone Secretion in Experimental Endotoxaemia, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 24, Pages: 862-873, ISSN: 0953-8194

Journal article

John CD, Gavins FNE, Buss NAPS, Cover PO, Buckingham JCet al., 2008, Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects, CURRENT OPINION IN PHARMACOLOGY, Vol: 8, Pages: 765-776, ISSN: 1471-4892

Journal article

John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E, Buckingham JCet al., 2007, Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides, FASEB JOURNAL, Vol: 21, Pages: 1037-1046, ISSN: 0892-6638

Journal article

Warne JP, John CD, Christian HC, Morris JF, Flower RJ, Sugden D, Solito E, Gillies GE, Buckingham JCet al., 2006, Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 291, Pages: E1264-E1273, ISSN: 0193-1849

Journal article

John CD, Theogaraj E, Christian HC, Morris JF, Smith SF, Buckingham JCet al., 2006, Time-specific effects of perinatal glucocorticoid treatment on anterior pituitary morphology, annexin 1 expression and adrenocorticotrophic hormone secretion in the adult female rat, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 18, Pages: 949-959, ISSN: 0953-8194

Journal article

Theogaraj E, John CD, Dewar A, Buckingham JC, Smith SFet al., 2006, The long-term effects of perinatal glucocorticoid exposure on the host defence system of the respiratory tract, JOURNAL OF PATHOLOGY, Vol: 210, Pages: 85-93, ISSN: 0022-3417

Journal article

Buckingham JC, Sahni V, Morris JF, Christian HC, Solito E, John CDet al., 2006, Annexin 1 dependent actions of glucocorticoids in the anterior pituitary gland - role of the formyl peptide receptor family, 6th International Congress of Neuroendocrinology, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: 53-54, ISSN: 0091-3022

Conference paper

McArthur S, Siddique ZL, Christian HC, Capone G, Theogaraj E, John CD, Smith SF, Morris JF, Buckingham JC, Gillies GEet al., 2006, Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats, ENDOCRINOLOGY, Vol: 147, Pages: 1904-1915, ISSN: 0013-7227

Journal article

Rodrigues-Lisoni FC, Mehemet DK, Peitl P, John CD, Tajara E, Buckingham JC, Solito Eet al., 2006, In vitro and in vivo studies on CCR10 regulation by Annexin A1, FEBS LETTERS, Vol: 580, Pages: 1431-1438, ISSN: 1873-3468

Journal article

Buckingham JC, John CD, Solito E, Tierney T, Flower RJ, Christian H, Morris Jet al., 2006, Annexin 1, glucocorticoids, and the neuroendocrine-immune interface, NEUROENDOCRINE AND IMMUNE CROSSTALK, Vol: 1088, Pages: 396-409, ISSN: 0077-8923

Journal article

Theogaraj E, John CD, Christian HC, Morris JF, Smith SF, Buckingham JCet al., 2005, Perinatal glucocorticoid treatment produces molecular, functional, and morphological changes in the anterior pituitary gland of the adult male rat, ENDOCRINOLOGY, Vol: 146, Pages: 4804-4813, ISSN: 0013-7227

Journal article

John CD, Christian HC, Morris JF, Flower RJ, Solito E, Buckingham JCet al., 2004, Annexin 1 and the regulation of endocrine function, TRENDS IN ENDOCRINOLOGY AND METABOLISM, Vol: 15, Pages: 103-109, ISSN: 1043-2760

Journal article

John CD, Christian HC, Morris JF, Flower RJ, Solito E, Buckingham JCet al., 2003, Kinase-dependent regulation of the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin 1 peptides, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 15, Pages: 946-957, ISSN: 0953-8194

Journal article

John CD, Buckingham JC, 2003, Cytokines: regulation of the hypothalamo-pituitary-adrenocorticaI axis, CURRENT OPINION IN PHARMACOLOGY, Vol: 3, Pages: 78-84, ISSN: 1471-4892

Journal article

Buckingham JC, Solito E, John CD, Tierney T, Taylor AD, Flower RJ, Christian HC, Morris JFet al., 2003, Annexin 1: A paracrine/juxtacrine mediator of glucocorticoid action in the neuroendocrine system, Cell Biochemistry and Function, Vol: 21, Pages: 217-221

Journal article

John C, Cover P, Solito E, Morris J, Christian H, Flower R, Buckingham Jet al., 2002, Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: Roles of the N-terminal domain and protein kinase C, ENDOCRINOLOGY, Vol: 143, Pages: 3060-3070, ISSN: 0013-7227

Journal article

Cover PO, Baanah-Jones F, John CD, Buckingham JCet al., 2002, Annexin 1 (lipocortin 1) mimics inhibitory effects of glucocorticoids on testosterone secretion and enhances effects of interleukin-1 beta, ENDOCRINE, Vol: 18, Pages: 33-39, ISSN: 0969-711X

Journal article

John CD, Theogaraj E, Dewar A, Smith SF, Buckingham JCet al., 2002, Effects of perinatal dexamethasone treatment on immune cell distribution in the adult rat., BRITISH JOURNAL OF PHARMACOLOGY, Vol: 135, ISSN: 0007-1188

Journal article

Theogaraj E, John CD, Smith SF, Buckingham JCet al., 2002, The programming actions of glucocorticoids on ANXA-1 expression in the hypothalamic-pituitary adrenal axis of adult rats treated perinatally with dexamethasone, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 135, ISSN: 0007-1188

Journal article

Philip JG, John CD, Cover PO, Morris JF, Christian HC, Flower RJ, Buckingham JCet al., 2001, Opposing influences of glucocorticoids and interleukin-1 beta on the secretion of growth hormone and ACTH in the rat in vivo: role of hypothalamic annexin 1, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 134, Pages: 887-895, ISSN: 0007-1188

Journal article

John CD, Solito E, Mulla A, Morris JF, Flower RJ, Buckingham JCet al., 2001, Dexamethasone induces serine phosphorylation of annexin 1 in pituitary cells and suppresses ACTH release by a PKC-dependent mechanism., BRITISH JOURNAL OF PHARMACOLOGY, Vol: 133, Pages: U20-U20, ISSN: 0007-1188

Journal article

Taylor AD, Philip JG, John CD, Cover PO, Morris JF, Flower RJ, Buckingham JCet al., 2000, Annexin 1 (Lipocortin 1) mediates the glucocorticoid inhibition of cyclic adenosine 3 ',5 '-monophosphate-stimulated prolactin secretions, ENDOCRINOLOGY, Vol: 141, Pages: 2209-2219, ISSN: 0013-7227

Journal article

John CD, Cover PO, Taylor AD, Morris JF, Flower RJ, Solito E, Buckingham JCet al., 1999, Evidence from in vivo and in vitro studies that the inhibitory actions of lipocortin 1 on anterior pituitary function require amino acid residues 13-26, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 126, Pages: U74-U74, ISSN: 0007-1188

Journal article

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