Imperial College London

DrCarelLe Roux

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Investigative Science



+44 (0)7970 719 453c.leroux




08, east wingCharing Cross HospitalCharing Cross Campus





Most relevant original publications

 Walters JR, Tasleem AM, Omer OS, Brydon WG, Dew T, le Roux CW. A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis. Clin Gastroenterol Hepatol. 2009 May 6. [Epub ahead of print]

 Pournaras DJ, le Roux CW. After bariatric surgery what vitamins should be measured and what supplements should be given? Clin Endocrinol (Oxf). 2009 Feb 25. [Epub ahead of print]

 le Roux CW, Borg CM, Murphy KG, Vincent RP, Ghatei MA, Bloom SR. Supraphysiological doses of intravenous PYY(3-36) cause nausea, but no additional reduction in food intake. Ann Clin Biochem. 2008 Jan;45:93-5.

 le Roux CW, Welbourn R, Werling M, Osborne A, Kokkinos A, Laurenius A, Lönroth H, Fändriks L, Ghatei MA, Bloom SR, Olbers T. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Annals of Surgery 2007 Nov;246(5):780-785.

 Borg CM, le Roux CW, Ghatei MA, Bloom SR, Patel AG. Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels. Obes Surg. 2007 Sep;17(9):1193-8.

 le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, Kent A, Vincent RP, Gardiner J, Ghatei MA, Bloom SR. Attenuated peptide YY release in obese subjects is associated with reduced satiety.Endocrinology. 2006 Jan;147(1):3-8

 le Roux CW, Aylwin SJB, Batterham RL, Borg CM, Coyle F, Prasad V, Shurey S, Ghatei MA, Patel AG, Bloom SR. Gut hormone profiles following bariatric surgery favour an anorectic state, facilitate weight loss and improve metabolic parameters. Annals of Surgery. 2006 Jan;243(1):108-14.

 Borg CM, le Roux CW, Ghatei MA, Bloom SR, Patel AG , Aylwin SJB. Progressive rise in gut hormones after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Brit J Surg. 2006 Jan 3;93(2):210-215

 le Roux CW, Neary NM, Halsey TJ, Small CJ, Martinez-Isla AM, Ghatei MA, Theodorou NA, Bloom SR. Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. J Clin Endocrinol Metab. 2005 Aug;90(8):4521-4. Epub 2005 May 24.

 le Roux CW, Ghatei MA, Gibbs JS, Bloom SR. The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension. Heart. 2005 Feb;91(2):241-2.

 le Roux CW, Patterson M, Vincent RP, Hunt C, Ghatei MA, Bloom SR. Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects. J Clin Endocrinol Metab. 2005 Feb;90(2):1068-71.

 le Roux CW, Mulla A, Meeran K. Pituitary carcinoma as a cause of acromegaly. New England Journal of Medicine, 2001, 35, 1645-1646



Gomide Braga T, das Graças Coelho de Souza M, Maranhão PA, et al., 2020, Evaluation of Heart Rate Variability and Endothelial Function 3 Months After Bariatric Surgery., Obes Surg

McCrimmon RJ, Catarig A-M, Frias JP, et al., 2020, Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial, Diabetologia, ISSN:0012-186X

Friedman AN, Wang J, Wahed AS, et al., 2019, The Association Between Kidney Disease and Diabetes Remission in Bariatric Surgery Patients With Type 2 Diabetes, American Journal of Kidney Diseases, Vol:74, ISSN:0272-6386, Pages:761-770

Grannell A, Al-Najim W, Mangan A, et al., 2019, Fat free mass is positively associated with hunger and energy intake at extremes of obesity, Appetite, Vol:143, ISSN:0195-6663

Wallenius V, Elias E, Elebring E, et al., 2019, Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet., Gut

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