Publications
300 results found
Byrne AJ, Jones CP, Gowers K, et al., 2013, Lung Macrophages Contribute to House Dust Mite Driven Airway Remodeling via HIF-1α, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 26
Lloyd CM, Saglani S, 2013, T cells in asthma: Influences of genetics, environment, and T-cell plasticity, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 131, Pages: 1267-1275, ISSN: 0091-6749
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- Citations: 71
Krauss-Etschmann S, Bush A, Bellusci S, et al., 2013, Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease, THORAX, Vol: 68, Pages: 380-384, ISSN: 0040-6376
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- Citations: 28
Gregory LG, Jones CP, Walker SA, et al., 2013, IL-25 drives remodelling in allergic airways disease induced by house dust mite, THORAX, Vol: 68, Pages: 82-90, ISSN: 0040-6376
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- Citations: 128
Hammond VJ, Morgan AH, Lauder S, et al., 2012, Novel Keto-phospholipids Are Generated by Monocytes and Macrophages, Detected in Cystic Fibrosis, and Activate Peroxisome Proliferator-activated Receptor-γ, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 287, Pages: 41651-41666
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- Citations: 48
Ullmann N, Adams A, Bossley CJ, et al., 2012, IL-33 and airway remodelling in paediatric severe therapy resistant asthma, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Tan H, Moody S, Murdoch J, et al., 2012, CHANGES IN NASAL MUCOSAL INFLAMMATORY CELL PHENOTYPE IN CYSTIC FIBROSIS (CF) MICE, PEDIATRIC PULMONOLOGY, Vol: 47, Pages: 266-267, ISSN: 8755-6863
Habibzay M, Saldana JI, Goulding J, et al., 2012, Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung, MUCOSAL IMMUNOLOGY, Vol: 5, Pages: 524-534, ISSN: 1933-0219
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- Citations: 49
Zhao J, Lloyd CM, Noble A, 2012, Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling, Mucosal Immunology, Vol: 6, Pages: 335-346, ISSN: 1935-3456
The role of T-helper type 17 (Th17) responses in airway remodeling in asthma is currently unknown. We demonstrate that both parenteral and mucosal allergen sensitization, followed by allergen inhalation, leads to Th17-biased lung immune responses. Unlike Th17 cells generated in vitro, lung Th17 cells did not produce tumor necrosis factor-α or interleukin (IL)-22. Eosinophilia predominated in acute inflammation, while neutrophilia and IL-17 increased in chronic disease. Allergen-induced tolerance involved Foxp3-, Helios-, and glycoprotein-A repetitions predominant-expressing regulatory T cells (Treg) and IL-10/interferon-γ priming. This Treg phenotype was altered in inflamed lungs and abrogated by inhalation of IL-17. Using Th17-deficient mice with genetic disruption of gp130 in T cells, we showed that Th17 cells induce airway remodeling independent of the Th2 response. All-trans retinoic acid administration ameliorated Th17-mediated disease and increased Treg activity, while dexamethasone inhibited eosinophilia but not neutrophilia, and enhanced Th17 development in vitro. Targeting the Th17/Treg axis might therefore be therapeutic in neutrophilic and glucocorticoid-refractory asthma.
Bossley CJ, Fleming L, Gupta A, et al., 2012, Pediatric severe asthma is characterized by eosinophilia and remodeling without T<sub>H</sub>2 cytokines, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 129, Pages: 974-U469, ISSN: 0091-6749
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- Citations: 241
Jones CP, Gregory LG, Causton B, et al., 2012, Activin A and TGF-β promote T<sub>H</sub>9 cell-mediated pulmonary allergic pathology, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 129, Pages: 1000-U512, ISSN: 0091-6749
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- Citations: 134
Tan H-L, Davies J, Brown S, et al., 2012, Interleukin-17 and Cystic Fibrosis Lung Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 185, Pages: 109-110, ISSN: 1073-449X
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- Citations: 1
Williams AE, Hussell T, Lloyd C, 2012, Immunology of the Gastrointestinal Tract, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 133-155, ISBN: 978-0-470-09003-9
Williams AE, Hussell T, Lloyd C, 2012, Chemokines, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 93-110, ISBN: 978-0-470-09003-9
Williams AE, Hussell T, Lloyd C, 2012, Cytokines, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 68-92, ISBN: 978-0-470-09003-9
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- Citations: 1
Williams AE, Hussell T, Lloyd C, 2012, The Adaptive Immune System, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 41-67, ISBN: 978-0-470-09003-9
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- Citations: 2
Williams AE, Hussell T, Lloyd C, 2012, The Innate Immune System, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 20-40, ISBN: 978-0-470-09003-9
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- Citations: 1
Williams AE, Hussell T, Lloyd C, 2012, Immunology Mucosal and Body Surface Defences Preface, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: XV-XVI, ISBN: 978-0-470-09003-9
Williams AE, Hussell T, Lloyd C, 2012, Immunology of the Urogenital Tract and Conjunctiva, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 177-195, ISBN: 978-0-470-09003-9
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- Citations: 1
Williams AE, Hussell T, Lloyd C, 2012, Immunology of the Airways, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 156-176, ISBN: 978-0-470-09003-9
Williams AE, Hussell T, Lloyd C, 2012, Immunology of the Skin, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 196-216, ISBN: 978-0-470-09003-9
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- Citations: 1
Williams AE, Hussell T, Lloyd C, 2012, Immunity to Bacteria, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 238-257, ISBN: 978-0-470-09003-9
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- Citations: 1
Williams AE, Hussell T, Lloyd C, 2012, Immunity to Fungi, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 258-277, ISBN: 978-0-470-09003-9
Williams AE, Hussell T, Lloyd C, 2012, Immunity to Viruses, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 217-237, ISBN: 978-0-470-09003-9
Williams AE, Hussell T, Lloyd C, 2012, Disorders of the Immune System, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 302-321, ISBN: 978-0-470-09003-9
Williams AE, Hussell T, Lloyd C, 2012, Immunity to Parasites, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 278-301, ISBN: 978-0-470-09003-9
Williams AE, Hussell T, Lloyd C, 2012, Mucosal Tumour Immunology, IMMUNOLOGY: MUCOSAL AND BODY SURFACE DEFENCES, Publisher: BLACKWELL SCIENCE PUBL, Pages: 322-341, ISBN: 978-0-470-09003-9
Mathie SA, Hussell T, Lloyd CM, 2011, The role of alveolar macrophages in the resolution of house dust mite induced allergic airways disease, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 139-139, ISSN: 0019-2805
Gregory L, Jones CP, Causton B, et al., 2011, TH9 cells promote mast cell mediated allergic pathology in the lung <i>in vivo</i>, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 71-71, ISSN: 0019-2805
Vasiliou J, Lui S, Walker S, et al., 2011, Effects of vitamin D deficiency during early life on the development of neonatal house dust mite induced allergic airways disease, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 204-204, ISSN: 0019-2805
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