Imperial College London
Alternate

ProfessorClareLloyd

Faculty of Medicine, National Heart & Lung Institute

Interim Head of NHLI, Vice-Dean (institutional Affairs) FoM
 
 
 
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Contact

 

+44 (0)20 7594 3102c.lloyd Website

 
 
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Location

 

Office 352Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Saglani:2019:10.1016/B978-0-323-44887-1.00007-9,
author = {Saglani, S and Lloyd, CM and Bush, A},
booktitle = {Kendig's Disorders of the Respiratory Tract in Children},
doi = {10.1016/B978-0-323-44887-1.00007-9},
pages = {101--119.e4},
title = {Biology and Assessment of Airway Inflammation},
url = {http://dx.doi.org/10.1016/B978-0-323-44887-1.00007-9},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - The nature and development airway inflammation may be driven by numerous factors, including pathogenic infections, pollution, or even relatively innocuous inhaled particles, such as allergens. A robust inflammatory response is essential to fight pathogens, but both active inflammation and efficient resolution are equally important. The failure of resolution or persistent proinflammatory immune responses results in chronic inflammatory airway diseases. These may be characterized by persistent neutrophilic inflammation, as is the case in cystic fibrosis and chronic suppurative lung diseases, or persistent eosinophilia, as is seen in allergic asthma. It is essential to accurately undertake an assessment of the airway inflammatory phenotype in chronic airways diseases to allow an understanding of the mechanisms mediating disease and identify appropriate therapeutic targets. It is also becoming increasingly important to phenotype airway inflammation in individual patients to allow targeted treatment as we move towards personalized therapies. This chapter will discuss what is known about the mechanisms driving chronic inflammatory airways diseases in children and provide an update on the methods used to investigate airway inflammation invasively and noninvasively in patients to allow phenotype driven and targeted therapies.
AU  - Saglani,S
AU  - Lloyd,CM
AU  - Bush,A
DO  - 10.1016/B978-0-323-44887-1.00007-9
EP  - 119
PY  - 2019///
SN  - 9780323448871
SP  - 101
TI  - Biology and Assessment of Airway Inflammation
T1  - Kendig's Disorders of the Respiratory Tract in Children
UR  - http://dx.doi.org/10.1016/B978-0-323-44887-1.00007-9
ER  -
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