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@article{Abeler-Dorner:2020:10.1038/s41590-019-0549-0,
author = {Abeler-Dorner, L and Laing, AG and Lorenc, A and Ushakov, DS and Clare, S and Speak, AO and Duque-Correa, MA and White, JK and Ramirez-Solis, R and Saran, N and Bull, KR and Moron, B and Iwasaki, J and Barton, PR and Caetano, S and Hng, KI and Cambridge, E and Forman, S and Crockford, TL and Griffiths, M and Kane, L and Harcourt, K and Brandt, C and Notley, G and Babalola, KO and Warren, J and Mason, JC and Meeniga, A and Karp, NA and Melvin, D and Cawthorne, E and Weinrick, B and Rahim, A and Drissler, S and Meskas, J and Yue, A and Lux, M and Song-Zhao, GX and Chan, A and Reviriego, CB and Abeler, J and Wilson, H and Przemska-Kosicka, A and Edmans, M and Strevens, N and Pasztorek, M and Meehan, TF and Powrie, F and Brinkman, R and Dougan, G and Jacobs, W and Lloyd, CM and Cornall, RJ and Maloy, KJ and Grencis, RK and Griffiths, GM and Adams, DJ and Hayday, AC},
doi = {10.1038/s41590-019-0549-0},
journal = {Nature Immunology},
pages = {86--100},
title = {High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation},
url = {http://dx.doi.org/10.1038/s41590-019-0549-0},
volume = {21},
year = {2020}
}

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TY  - JOUR
AB  - By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation (http://www.immunophenotype.org). Specifically, high-throughput phenotyping of 530 unique mouse gene knockouts identified 140 monogenic ‘hits’, of which most had no previous immunologic association. Furthermore, hits were collectively enriched in genes for which humans show poor tolerance to loss of function. The immunophenotyping platform also exposed dense correlation networks linking immune parameters with each other and with specific physiologic traits. Such linkages limit freedom of movement for individual immune parameters, thereby imposing genetically regulated ‘immunologic structures’, the integrity of which was associated with immunocompetence. Hence, we provide an expanded genetic resource and structural perspective for understanding and monitoring immune variation in health and disease.
AU  - Abeler-Dorner,L
AU  - Laing,AG
AU  - Lorenc,A
AU  - Ushakov,DS
AU  - Clare,S
AU  - Speak,AO
AU  - Duque-Correa,MA
AU  - White,JK
AU  - Ramirez-Solis,R
AU  - Saran,N
AU  - Bull,KR
AU  - Moron,B
AU  - Iwasaki,J
AU  - Barton,PR
AU  - Caetano,S
AU  - Hng,KI
AU  - Cambridge,E
AU  - Forman,S
AU  - Crockford,TL
AU  - Griffiths,M
AU  - Kane,L
AU  - Harcourt,K
AU  - Brandt,C
AU  - Notley,G
AU  - Babalola,KO
AU  - Warren,J
AU  - Mason,JC
AU  - Meeniga,A
AU  - Karp,NA
AU  - Melvin,D
AU  - Cawthorne,E
AU  - Weinrick,B
AU  - Rahim,A
AU  - Drissler,S
AU  - Meskas,J
AU  - Yue,A
AU  - Lux,M
AU  - Song-Zhao,GX
AU  - Chan,A
AU  - Reviriego,CB
AU  - Abeler,J
AU  - Wilson,H
AU  - Przemska-Kosicka,A
AU  - Edmans,M
AU  - Strevens,N
AU  - Pasztorek,M
AU  - Meehan,TF
AU  - Powrie,F
AU  - Brinkman,R
AU  - Dougan,G
AU  - Jacobs,W
AU  - Lloyd,CM
AU  - Cornall,RJ
AU  - Maloy,KJ
AU  - Grencis,RK
AU  - Griffiths,GM
AU  - Adams,DJ
AU  - Hayday,AC
DO  - 10.1038/s41590-019-0549-0
EP  - 100
PY  - 2020///
SN  - 1529-2908
SP  - 86
TI  - High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation
T2  - Nature Immunology
UR  - http://dx.doi.org/10.1038/s41590-019-0549-0
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000515136500016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41590-019-0549-0
UR  - http://hdl.handle.net/10044/1/85999
VL  - 21
ER  -

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