Dr. Constandina Pospori is a Research Associate in the Bone Marrow Dynamics group, within the Department of Life Sciences.
Constandina studied Medicine in University College London. Following her Intercalated BSc in Immunology and Cellular Pathology, she joined the UCL MB PhD programme. She obtained her MB BS degree in 2012 and her PhD in Tumour Immunology in 2013. In her PhD with Dr. Emma Morris and Professor Hans Stauss, she examined the effects of central and peripheral tolerance against T cells expressing a high avidity T cell receptor specific for the tumour-associated antigen, WT1.
In 2013, Constandina joined Prof. Sara Rankin's group in the National Heart and Lung Institute where she studied the recruitment of endogenous progenitor cells with pro-angiogenic potential towards the site of Bioengineered transplants.
In 2016 she joined Dr. Cristina Lo Celso's group, where she is investigating the dynamic interactions between T cells, Acute Myeloid Leukaemia and Haematopoietic Stem cells throughout the course of disease as well as in the presence of T cell Immunotherapy.
Constandina is one of the co-ordinators of the Imperial Stem Cell and Regenerative Medicine Network. She is also interested in communicating science with the public and has been involved in the Imperial Fringe, the Imperial Festival as well as the Science Museum Lates.
et al., 2013, Human MHC Class I-restricted high avidity CD4(+) T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo, Oncoimmunology, Vol:2, ISSN:2162-4011
et al., 2011, Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination, Blood, Vol:117, ISSN:0006-4971, Pages:6813-6824
et al., 2010, Generation of multi-functional antigen-specific human T-cells by lentiviral TCR gene transfer, Gene Therapy, Vol:17, ISSN:0969-7128, Pages:721-732
et al., 2008, WT1-specific T cell receptor gene therapy: Improving TCR function in transduced T cells, Blood Cells Molecules and Diseases, Vol:40, ISSN:1079-9796, Pages:113-116
et al., 2007, Monoclonal T-cell receptors: New reagents for cancer therapy, Molecular Therapy, Vol:15, ISSN:1525-0016, Pages:1744-1750