Dr Raimondi has a long interest in cancer and vascular biology. He started his career in science in the cancer field as a master student in Palermo, Italy and continued his studied in cancer biology during his PhD within Professor Marco Falasca’s group at Queen Mary University in the UK. There, Dr Raimondi acquired a very strong background in cancer cell biology and learned how to dissect cell signalling pathways. Dr Raimondi’s PhD project focused on the role of Phosphoinositide-3-kinase- and phospholipase C gamma 1- dependent signalling pathways in breast and melanoma cancer cell migration, invasion and in metastasis dissemination.
After his PhD, Dr Raimondi took up a 10-months BHF-funded postdoctoral position in the vascular field in Professor Ruhrberg's lab at UCL to investigate the role of the transmembrane protein Neuropilin-1 in cell-cell adhesion. To continue his studies in the vascular field, Dr Raimondi successfully applied for a BHF immediate postdoctoral fellowship within Professor Ruhrberg’s group, that gave him the opportunity to lead his research project on Neuropilin-1 signalling in the angiogenic vasculature. Dr Raimondi research contributed to discover new Neuropilin-1-dependent signalling pathways activated by extracellular matrix components that regulate physiological and pathological angiogenesis.
Since, Dr Raimondi realised how important it is to increase the knowledge of basic mechanisms that regulate blood vessel growth and homeostasis to improve current treatment of vascular diseases. To continue to investigate Neuropilin-1-dependent signalling pathways and in particular the role of Neuropilin-1 in adult vasculature homeostasis, Dr Raimondi successfully applied for a BHF intermediate basic science research fellowship to join Professor Anna Randi’s group at the National Heart and Lung Institute.
Dr Raimondi current research focuses on identifying and investigating the signalling pathways controlled by Neuropilin-1 in endothelial cells that are involved in endothelial and vascular homeostasis. This research will determine whether the protective signals promoted by Neuropilin-1 in blood vessels are suppressed in vascular pathologies such as atherosclerosis and peripheral arterial disease.
et al., 2019, Neuropilin-1 controls endothelial homeostasis by regulating mitochondrial function and iron-dependent oxidative stress via ABCB8, Iscience, Vol:11, ISSN:2589-0042, Pages:205-223
et al., 2017, Dynamic regulation of canonical TGFβ signaling by endothelial transcription factor ERG protects from liver fibrogenesis, Nature Communications, Vol:8, ISSN:2041-1723
et al., 2017, VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation, Journal of Experimental Medicine, Vol:214, ISSN:0022-1007, Pages:1049-1064
et al., 2016, A small molecule inhibitor of PDK1/PLCγ1 interaction blocks breast and melanoma cancer cell invasion, Scientific Reports, Vol:6, ISSN:2045-2322
et al., 2017, VEGF165-Induced Vascular Permeability Requires NRP1 for ABL-Mediated SRC Family Kinase Activation, 2nd Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO), KARGER, Pages:45-46, ISSN:1018-1172