Imperial College London
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DrCandiceRoufosse

Faculty of Medicine, Department of Immunology and Inflammation

Clinical Reader in Renal Pathology
 
 
 
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Contact

 

+44 (0)20 3313 3280c.roufosse

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nikolopoulou:2021:ckj/sfaa026,
author = {Nikolopoulou, A and Teixeira, C and Cook, H and Roufosse, C and Cairns, THD and Levy, JB and Pusey, C and Griffith, ME},
doi = {ckj/sfaa026},
journal = {Clinical Kidney Journal},
pages = {876--883},
title = {Membranous nephropathy associated with viral infection},
url = {http://dx.doi.org/10.1093/ckj/sfaa026},
volume = {14},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundMembranous nephropathy (MN) can be associated with hepatitis infection and less commonly with human immunodeficiency virus (HIV) infection. The significance of anti-phospholipase A2 receptor (PLA2R) and anti-thrombospondin type 1 domain-containing 7A (THSD7A) antibodies in this setting is unclear.MethodsWe describe the clinical, histopathological and outcome data of 19 patients with MN and hepatitis B virus (HBV), hepatitis C virus (HCV) or HIV infection identified through our renal biopsy database and the association with anti-PLA2R antibodies and anti-THSD7A antibodies.ResultsThe cohort consisted of 19 patients, 8 male and 11 female, with a median age of 42 years (range 23–74). HBV infection was found in six cases, HCV in four and HIV in nine (two HIV patients had HBV co-infection and one HCV co-infection). PLA2R staining on biopsy was positive in 10/19 patients: 4 with HBV-MN, 3 with HCV-MN and 3 with HIV-MN and circulating anti-PLA2R antibodies were detected in 7/10 cases. THSD7A staining on biopsy was positive in three PLA2R-negative cases, one with HBV-MN and two with HIV-MN. Mean proteinuria was higher in the PLA2R-positive group and the median urinary protein:creatinine ratio (uPCR) was 963 mg/mmol (range 22–2406) compared with the PLA2R-negative group [median uPCR 548 mg/mmol (range 65–1898); P = 0.18 Mann–Whitney]. Spontaneous remission occurred in 6/19 patients and after-treatment remission occurred in 7/11 patients. Renal function was preserved in all but two patients who required haemodialysis 2 and 11 years from diagnosis.ConclusionsWe describe a cohort of patients with MN associated with viral infection, including rare cases of HIV-MN with PLA2R and THSD7A positivity. The mechanism of coincidental or viral-related MN needs to be investigated further.
AU  - Nikolopoulou,A
AU  - Teixeira,C
AU  - Cook,H
AU  - Roufosse,C
AU  - Cairns,THD
AU  - Levy,JB
AU  - Pusey,C
AU  - Griffith,ME
DO  - ckj/sfaa026
EP  - 883
PY  - 2021///
SN  - 2048-8505
SP  - 876
TI  - Membranous nephropathy associated with viral infection
T2  - Clinical Kidney Journal
UR  - http://dx.doi.org/10.1093/ckj/sfaa026
UR  - https://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfaa026/5820571
UR  - http://hdl.handle.net/10044/1/78511
VL  - 14
ER  -
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