Imperial College London

Dr Christopher F. Schuster

Faculty of MedicineDepartment of Medicine

Research Associate
 
 
 
//

Contact

 

+44 (0)20 7594 3094c.schuster

 
 
//

Location

 

3.40Flowers buildingSouth Kensington Campus

//

Summary

 

Summary

Christopher studied general biology at the University of Tübingen, Germany and Oregon State University, Corvallis, OR, USA with a research visit at the UMDNJ (now part of Rutgers), NJ, USA. He graduated from Tübingen with a major in microbiology and minors in biochemistry and cell biology.

He continued to pursue a PhD in microbiology at the University of Tübingen in the group of PD Dr. Ralph Bertram and Prof. Dr. Friedrich Götz where he focused on the role and activity of toxin-antitoxin systems from Staphylococci. His research identified active toxin-antitoxin systems in a non-pathogenic Staphylococcus species, challenging the idea that these systems are mainly involved in pathogenicity. He also investigated the mazEF toxin-antitoxin system from Staphylococcus aureus in more detail, to identify RNAs cleaved by the RNase toxin component, look into the regulatory feedback to the SigB sigma factor and probe the contribution of the TA system to beta-lactam sensitivity.

mazEF from Schuster and Betram, 2016

Christopher’s PhD worked had sparked an interest in prokaryotic signal transduction and regulation and brought him to his current post as a research associate in the group of Prof. Dr Angelika Gründling. Here, he investigated a novel target protein of the essential second messenger c-di-AMP named OpuC and this discovery has now linked c-di-AMP to S. aureus osmoprotection via the uptake of compatible solutes.

OpuC transporter from Schuster CF et al, Science Signaling, 2016

Christopher also enjoys communicating his science to the general public. An example of this can be found in the video below summarizing his latest research:

Second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in S. aureus from Schuster et al, Science Signaling, 2016

Currently, he funded by a 2 year Research Fellowship by the German Research Foundation (DFG).

More information and contact information can be found on his professional webpage.

 

Publications

Journals

Bowman L, Zeden MS, Schuster CF, et al., 2016, New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance in Staphylococcus aureus, Journal of Biological Chemistry, Vol:291, ISSN:0021-9258, Pages:26970-26986

Schuster CF, Bellows LE, Tosi T, et al., 2016, The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus, Science Signaling, Vol:9, ISSN:1945-0877

Schuster CF, Bertram R, 2016, Toxin-Antitoxin Systems of Staphylococcus aureus, Toxins, Vol:8, ISSN:2072-6651

Schuster CF, Mechler L, Nolle N, et al., 2015, The MazEF Toxin-Antitoxin System Alters the β-Lactam Susceptibility of Staphylococcus aureus., Plos One, Vol:10

Bertram R, Schuster CF, 2014, Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems, Frontiers in Cellular and Infection Microbiology, Vol:4, ISSN:2235-2988

More Publications