Imperial College London
Alternate

Claire L. Shovlin PhD FRCP

Faculty of Medicine, National Heart & Lung Institute

Professor of Practice (Clinical and Molecular Medicine)
 
 
 
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Contact

 

c.shovlin Website

 
 
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Location

 

534Block L Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gawecki:2019:10.1136/bmjresp-2018-000351,
author = {Gawecki, F and Myers, J and Shovlin, C},
doi = {10.1136/bmjresp-2018-000351},
journal = {BMJ Open Respiratory Research},
title = {The Veterans Specific Activity Questionnaire (VSAQ) - a new and efficient method of assessing exercise capacity in patients with pulmonary arteriovenous malformations},
url = {http://dx.doi.org/10.1136/bmjresp-2018-000351},
volume = {6},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Assessment  of  performance  status  is  an  important  component  of  clinical management  of  patients  with  pulmonary  arteriovenous  malformations  (PAVMs).  Usual  methods  are time-consuming and insensitive to variationswithinnormal or supranormal exercise capacity.METHODS: TheVeterans  Specific  Activity  Questionnaire  (VSAQ) wasmodifiedto  facilitate completion by patients independently. Patient-reported activity limitations were converted to the MRC Dyspnea scale, NYHA Classification,and metabolic equivalents (METs) in which 1 MET equals the consumption of 3.5 ml O2per kilogram of body weight. RESULTS: The study population of71 patients with PAVMswas aged 20-85 (median 52) years.SaO2was80-99.5%  (median  96%), and haemoglobin73-169g/L  in  females  and  123-197g/L  in  males (p<0.0001). CaO2(1.34  x  (haemoglobin  ×SaO2)/100)  was maintained  unless  iron  deficiency  was present.  Most patients(49/71, 69%) did not need to stop until activities more energetic than walking briskly at 4 miles  per hour were  achieved (VSAQ >5; MRC Dyspnea  Scale 1 or 2; NYHA Class  I). SaO2was inversely associated with the MRC Dyspnea scale and NYHA class, but not theVSAQ. Raw VSAQ scores  captured a marked  difference between malesand females. METSwere also higherin malesat 3.97-15.55(median  8.84)kcal/kg/hour, compared  to 1.33-14.4(median  8.25)kcal/kg/hour(p=0.0039).  There  was  only  a  modest  association  between  METsand  oxygen  saturation  (SaO2, p=0.044), but a  stronger  association  between METsand  haemoglobin  (p=0.001).In  crude  and  sex-adjusted regression, the arterial oxygen content (CaO2) was more strongly associated with METsthan either SaO2or haemoglobin in isolation.CONCLUSION: The  VSAQ,capturing patient  reported  outcome measures,is  an  efficient  and quantifiable measure of exercise capacity that can be readily employed in clinical services particularly wherepatients  have  normal  to  high  exercise  tolerance.  In th
AU  - Gawecki,F
AU  - Myers,J
AU  - Shovlin,C
DO  - 10.1136/bmjresp-2018-000351
PY  - 2019///
SN  - 2052-4439
TI  - The Veterans Specific Activity Questionnaire (VSAQ) - a new and efficient method of assessing exercise capacity in patients with pulmonary arteriovenous malformations
T2  - BMJ Open Respiratory Research
UR  - http://dx.doi.org/10.1136/bmjresp-2018-000351
UR  - http://hdl.handle.net/10044/1/66476
VL  - 6
ER  -
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