Imperial College London
Alternate

Claire L. Shovlin PhD FRCP

Faculty of Medicine, National Heart & Lung Institute

Professor of Practice (Clinical and Molecular Medicine)
 
 
 
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Contact

 

c.shovlin Website

 
 
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Location

 

534Block L Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hosman:2016:10.1007/s00432-016-2298-x,
author = {Hosman, AE and Shovlin, CL},
doi = {10.1007/s00432-016-2298-x},
journal = {Journal of Cancer Research and Clinical Oncology},
pages = {369--370},
title = {Cancer and hereditary haemorrhagic telangiectasia},
url = {http://dx.doi.org/10.1007/s00432-016-2298-x},
volume = {143},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveTo examine associations between cancer incidence and hereditary haemorrhagic telangiectasia (HHT).MethodsTwo studies with contrasting conclusions were compared. The first had used a registry-based, matched-pairs approach, while the second utilised HHT family-based, survey methodology.ResultsThe first manuscript captured data on cancer incidence in a total of 316,581 matched cancer patients–non-cancer controls, which included 431 HHT cases. No association was found between HHT and pooled cases of lung, breast, prostate, and colorectal cancer (adjusted OR 0.978, 95% CI [0.795, 1.204]). The second, which was powered to examine these four cancers individually, captured data from 2161 HHT cases and 2817 related controls. Fewer HHT-affected individuals had cancer (398/2161, [18.4%]) compared to 668/2817 (23.7%) related controls (p = 0.0012). Of the four most common cancers, prostate and colorectal cancer rates were equivalent, but lung cancers were significantly less frequent in HHT (adjusted OR 0.48 [0.30, 0.70], p = 0.0012), and breast cancer was more frequent (adjusted OR 1.52 [1.07, 2.14] p = 0.018).ConclusionsThe respective studies had different methodological strengths and weaknesses. Potential reasons for the discrepant conclusions include study power, particularly important to dissect specific cancers where differential contributions from HHT genotypes and environmental confounders might be predicted.
AU  - Hosman,AE
AU  - Shovlin,CL
DO  - 10.1007/s00432-016-2298-x
EP  - 370
PY  - 2016///
SN  - 0171-5216
SP  - 369
TI  - Cancer and hereditary haemorrhagic telangiectasia
T2  - Journal of Cancer Research and Clinical Oncology
UR  - http://dx.doi.org/10.1007/s00432-016-2298-x
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000392629100020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/51327
VL  - 143
ER  -
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