Summary
Cesare Terracciano is Professor of Cardiac Electrophysiology and PI of the British Heart Foundation Cardiovascular Regenerative Centre. Professor Terracciano graduated in Medicine at the Universita' La Sapienza of Roma, Italy, and qualified in Cardiology in the same medical school. He obtained his PhD in Physiology at the National Heart & Lung Institute, London. In 1998 he received a Wellcome Trust Career Development Fellowship and his work is now funded by the Medical Research Council, the British Heart Foundation, the Wellcome Trust and the NC3Rs. In his career, he was one of the first to study the mode of regulation of cardiac calcium transporters. the effects of manipulating calcium transporter expression using transgenic technology, myocardial and microdomain plasticity in response to mechanical unloading with left ventricular assist devices, characterise modalities of application and the paracrine effects of cell transplantation, and define the electrophysiological properties of stem cell-derived cardiac myocytes, their chamber specificity and their use in tissue engineering.
Professor Terracciano's main interest is the elecrophysiology of heart failure and the consequences of treatment on the contractile and electrical properties of the heart. His research focuses in particular on the mechanisms of myocardial regeneration following mechanical devices or stem and gene therapy, and the cellular and molecular mechanisms of arrhythmias.
See Cesare Terracciano's profile in Circulation - European Perspectives 2010
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Selected Publications
Journal Articles
Kane C, Terracciano CMN, 2018, Human cardiac fibroblasts engage the sarcoplasmic reticulum in induced pluripotent stem cell-derived cardiomyocyte excitation-contraction coupling, Journal of the American College of Cardiology, Vol:72, ISSN:0735-1097, Pages:1061-1063
Ibrahim M, Terracciano CM, Yacoub MH, 2011, Bridge to Recovery: What Remains to be Discovered?, Cardiology Clinics, Vol:29, ISSN:0733-8651, Pages:531-+
Ibrahim M, Gorelik J, Yacoub MH, et al., 2011, The structure and function of cardiac t-tubules in health and disease, Proceedings of the Royal Society B: Biological Sciences, Vol:278, ISSN:0962-8452, Pages:2714-2723
Camelliti P, Abou Al-Saud S, Smolenski RT, et al., 2011, Adult human heart slices are a multicellular system suitable for electrophysiological and pharmacological studies, Journal of Molecular and Cellular Cardiology, Vol:51, ISSN:0022-2828, Pages:390-398
Ibrahim M, Al Masri A, Navaratnarajah M, et al., 2010, Prolonged mechanical unloading affects cardiomyocyte excitation-contraction coupling, transverse-tubule structure, and the cell surface, The FASEB Journal, Vol:24, ISSN:0892-6638, Pages:3321-3329
Chambers JC, Zhao J, Terracciano CMN, et al., 2010, Genetic variation in <i>SCN10A</i> influences cardiac conduction, Nature Genetics, Vol:42, ISSN:1061-4036, Pages:149-U80
Terracciano CM, Miller LW, Yacoub MH, 2010, Contemporary Use of Ventricular Assist Devices, Annual Review of Medicine, Vol:61, ISSN:0066-4219, Pages:255-270
Lee J, Stagg MA, Fukushima S, et al., 2009, Adult progenitor cell transplantation influences contractile performance and calcium handling of recipient cardiomyocytes, American Journal of Physiology - Heart and Circulatory Physiology, Vol:296, ISSN:0363-6135, Pages:H927-H936
Stagg MA, Carter E, Shorabi N, et al., 2008, Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart, Circulation Research, Vol:103, ISSN:0009-7330, Pages:855-863
Soppa GKR, Lee J, Stagg MA, et al., 2008, Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure, Cardiovascular Research, Vol:77, ISSN:1755-3245, Pages:695-706
Terracciano CMN, Hardy J, Birks EJ, et al., 2004, Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy, Circulation, Vol:109, ISSN:0009-7322, Pages:2263-2265