Publications
302 results found
Soppa G, Lee J, Stagg M, et al., 2006, Chronic clenbuterol treatment improves heart and myocyte function in heart failure, with and without mechanical unloading, 28th Annual International-Society-for-Heart-Research North American Section Meeting, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: 945-945, ISSN: 0022-2828
Soppa GK, Lee J, Stagg MA, et al., 2006, Chronic administration of clenbuterol to mechanically unloaded, failing hearts affects calcium handling and mycocyte function relevance to LVAD recovery, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 25, Pages: S143-S144, ISSN: 1053-2498
Felkin LE, Birks EJ, Soppa GK, et al., 2006, Matrix metalloproteinase (MMP) and tissue inhibitor of MMPs (TIMP) gene expression in myocardial recovery from heart failure, Annual Autumn Meeting of the British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, ISSN: 1355-6037
Lee J, Fukushima S, Stagg MA, et al., 2006, Paracrine effects of transplanted bone marrow cells and skeletal myoblasts on recipient cardiomyocyte function in a rat model of heart failure, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 25, Pages: S152-S152, ISSN: 1053-2498
Stagg MA, Coppen SR, Suzuki K, et al., 2006, Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation, FASEB JOURNAL, Vol: 20, Pages: 744-+, ISSN: 0892-6638
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- Citations: 23
Fukushima S, Brindley G, Yamahara K, et al., 2005, Direct intramyocardial injection, but not intracoronary infusion of bone marrow mononuclear cells induces ventricular arrhythmias in chronic ischemic heart failure, 78th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: U695-U695, ISSN: 0009-7322
Soppa GKR, Smolenski RT, Latif N, et al., 2005, "Effects of chronic administration of clenbuterol on function and metabolism of adult rat cardiac muscle." (vol 288, pg H1468, 2005), AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 288, Pages: H2546-H2546, ISSN: 0363-6135
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- Citations: 2
Comini L, Boraso A, Bachetti T, et al., 2005, Effects of endotoxic shock on neuronal NOS and calcium transients in rat cardiac myocytes, PHARMACOLOGICAL RESEARCH, Vol: 51, Pages: 409-417, ISSN: 1043-6618
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- Citations: 23
Soppa GKR, Smolenski RT, Latif N, et al., 2005, Effects of chronic administration of clenbuterol on function and metabolism of adult rat cardiac muscle, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 288, Pages: H1468-H1476, ISSN: 0363-6135
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- Citations: 50
Stagg MA, Terracciano CMN, 2005, Less Na<SUP>+</SUP>/H<SUP>+</SUP>-exchanger to treat heart failure:: a simple solution for a complex problem?, CARDIOVASCULAR RESEARCH, Vol: 65, Pages: 10-12, ISSN: 0008-6363
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- Citations: 2
Coppen SR, Varela-Carver A, Stagg MA, et al., 2004, An investigation of gap junction formation between skeletal myoblasts and adult cardiac myocytes using myoblasts overexpressing Connexin43, 77th Scientific Meeting of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 396-396, ISSN: 0009-7322
Stagg MA, Coppen SR, Lee A, et al., 2004, Connexin43 overexpression increases gap junctional conductance between skeletal myoblasts and adult rat ventricular myocytes in coculture, 77th Scientific Meeting of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 280-280, ISSN: 0009-7322
Stagg MA, Malik AH, MacLeod KT, et al., 2004, The effects of overexpression of the Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchanger on calcium regulation in hypertrophied mouse cardiac myocytes, CELL CALCIUM, Vol: 36, Pages: 111-118, ISSN: 0143-4160
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- Citations: 10
Terracciano CMN, Hardy J, Birks EJ, et al., 2004, Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy, CIRCULATION, Vol: 109, Pages: 2263-2265, ISSN: 0009-7322
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- Citations: 110
Hardy J, Terracciano C, Tansley P, et al., 2004, Changes in QT interval and action potential duration during and after left ventricular assist device (LVAD) induced recovery, Annual Conference of the British-Cardiac-Society, Publisher: B M J PUBLISHING GROUP, Pages: A50-A51, ISSN: 1355-6037
Sato M, Gong HB, Terracciano CMN, et al., 2004, Loss of β-adrenoceptor response in myocytes overexpressing the Na<SUP>+</SUP>/Ca<SUP>2+</SUP> -exchanger, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 36, Pages: 43-48, ISSN: 0022-2828
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- Citations: 35
Sato M, Terracciano CM, Ranu HK, et al., 2003, Beta2-adrenoceptor coupling to the Na/Ca exchanger depresses contraction in adult rat ventricular myocytes, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 179-180, ISSN: 0009-7322
Soppa GK, Malik AH, Terracciano CM, et al., 2003, Chronic administration of clenbuterol affects ventricular myocyte size and calcium handling in rats, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 331-331, ISSN: 0009-7322
Terracciano CM, Birks E, Hardy J, et al., 2003, Clinical recovery with successful LVAD explantation correlates with increased sarcoplasmic reticulum (SR) Ca content but not with regression of cellular hypertrophy, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 430-430, ISSN: 0009-7322
Terracciano CMN, Harding SE, Adamson D, et al., 2003, Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy, EUROPEAN HEART JOURNAL, Vol: 24, Pages: 1329-1339, ISSN: 0195-668X
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- Citations: 56
Terracciano C, 2002, Functional consequences of Na/Ca exchanger overexpression in cardiac myocytes., Ann N Y Acad Sci, Vol: 976, Pages: 520-527, ISSN: 0077-8923
Several factors are important in the relationship between Na/Ca exchanger overexpression and Ca cycling in physiological and pathophysiological situations. First, there are species differences. Transgenic mouse cardiac myocytes overexpressing Na/Ca exchanger showed a faster Ca transient associated with increased sarcoplasmic reticulum (SR) Ca content compared with wild-type myocytes. Cultured rabbit cardiac myocytes overexpressing Na/Ca exchanger showed reduced amplitude of the Ca transient and reduced SR Ca content. Second, the activity of other Ca regulatory proteins have to be considered. When Ca uptake via SR Ca ATPase (SERCA) was reduced by thapsigargin in transgenic mouse myocytes overexpressing Na/Ca exchanger, the time course of the Ca transient was slowed, and the SR Ca content was reduced to wild-type mouse myocyte levels, suggesting a potential compensatory role of Na/Ca exchanger overexpression when SERCA function is reduced. Finally, there are confounding factors related to the pathophysiological conditions. Our results suggest that Na/Ca exchanger overexpression can compensate for defects in SR Ca uptake in mouse myocytes. The consequences of Na/Ca exchanger overexpression in other species and conditions is unpredictable and require further investigation.
Terracciano CMN, Hajjar RJ, Harding SE, 2002, Overexpression of SERCA2a accelerates repolarisation in rabbit ventricular myocytes, CELL CALCIUM, Vol: 31, Pages: 299-305, ISSN: 0143-4160
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- Citations: 19
Ranu HK, Terracciano CMN, Davia K, et al., 2002, Effects of Na<SUP>+</SUP>/Ca<SUP>2+</SUP>-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 34, Pages: 389-400, ISSN: 0022-2828
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- Citations: 46
Stagg MA, Malik AH, James PF, et al., 2002, Changes in Na/K pump isoform expression alters Ca handling in hypertrophied mouse cardiomyocytes, BIOPHYSICAL JOURNAL, Vol: 82, Pages: 602A-603A, ISSN: 0006-3495
Terracciano CMN, 2002, NCX overexpression in cardiac myocytes, Cellular and molecular physiology of Sodium - Calcium exchange, Editors: Lytton, Schnetkamp, Hryshko, Blaunstein, New York, Publisher: New York Academy of Science, Pages: 520-527
Terracciano C, 2002, Functional consequences of Na/Ca exchanger overexpression in cardiac myocytes, 4th International Conference on Cellular and Molecular Physiology of Sodium-Calcium Exchange, Publisher: NEW YORK ACAD SCIENCES, Pages: 520-527, ISSN: 0077-8923
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- Citations: 11
Stagg MA, Smith JN, Macleod KT, et al., 2001, Ca sparks in transgenic mice overexpressing the Na/Ca exchanger exposed to a sustained angiotensin II infusion, CIRCULATION, Vol: 104, Pages: 280-280, ISSN: 0009-7322
Terracciano CM, Koban M, Harding SE, et al., 2001, Changes in sarcolemmal Ca entry and sarcoplasmic reticulum (SR) Ca content in isolated ventricular myocytes from patients with end-stage heart failure following left ventricular assist device support, CIRCULATION, Vol: 104, Pages: 480-481, ISSN: 0009-7322
Terracciano CM, 2001, Rapid inhibition of the Na+-K+ pump affects Na+-Ca2+ exchanger-mediated relaxation in rabbit ventricular myocytes., J Physiol, Vol: 533, Pages: 165-173, ISSN: 0022-3751
The direct influence of Na+-K+ pump activity on the ability of the Na+-Ca2+ exchanger to remove Ca2+ was investigated in isolated adult rabbit ventricular myocytes. Cell shortening was measured using an edge-detection system. Cytoplasmic [Ca2+] was monitored using the fluorescent indicator indo-1. Electrophysiological parameters were recorded using high-resistance microelectrodes. The Na+-K+ pump was rapidly inhibited by removal of extracellular K+ and measurements were taken almost immediately to minimise effects on other cellular compartments. Activity of the Na+-Ca2+ exchanger was monitored during release of Ca2+ from the sarcoplasmic reticulum (SR) elicited by rapid application of 15 mM caffeine. When Na+-K+ pump activity was affected by K+ removal, cell relaxation and indo-1 fluorescence decline were slowed by approximately 40 %. The charge calculated by integrating the caffeine-induced transient inward current was unchanged, suggesting that there was no difference in the SR Ca2+ content in the two conditions. However Ca2+ flux via the Na+-Ca2+ exchanger was slower when the Na+-K+ pump was inhibited. Similar experiments were performed by inhibiting the Na+-K+ pump using 0.5 mM strophanthidin. In this condition similar results to the ones observed by K+ removal were obtained, suggesting a specific role of the Na+-K+ pump in the phenomenon observed. This study suggests that the activity of the Na+-K+ pump influences Na+-Ca2+ exchanger function in the absence of changes in SR Ca2+ content. This can be explained by a slower removal of Na+ from the subsarcolemmal space. The source of the increase in subsarcolemmal [Na+] requires further investigation. However, calculations derived from modelling suggest that the Na+-Ca2+ exchanger itself could be involved.
Davia K, Bernobich E, Ranu HK, et al., 2001, SERCA2a overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 33, Pages: 1005-1015, ISSN: 0022-2828
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- Citations: 68
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