Publications
302 results found
Stagg MA, Carter E, Sohrabi N, et al., 2008, Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart, CIRCULATION RESEARCH, Vol: 103, Pages: 855-U177, ISSN: 0009-7330
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- Citations: 41
Stagg MA, Carter E, Shorabi N, et al., 2008, Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart, Circulation Research, Vol: 103, Pages: 855-863, ISSN: 0009-7330
Soppa GKR, Lee J, Stagg MA, et al., 2008, Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure (vol 77, pg 695, 2008), CARDIOVASCULAR RESEARCH, Vol: 80, Pages: 159-159, ISSN: 0008-6363
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- Citations: 2
Fukushima S, Coppen SR, Lee J, et al., 2008, Choice of cell-delivery route for skeletal myoblast transplantation for treating post-infarction chronic heart failure in rat, PLOS One, Vol: 3, ISSN: 1932-6203
BackgroundIntramyocardial injection of skeletal myoblasts (SMB) has been shown to be a promising strategy for treating post-infarction chronic heart failure. However, insufficient therapeutic benefit and occurrence of ventricular arrhythmias are concerns. We hypothesised that the use of a retrograde intracoronary route for SMB-delivery might favourably alter the behaviour of the grafted SMB, consequently modulating the therapeutic effects and arrhythmogenicity.Methods and ResultsThree weeks after coronary artery ligation in female wild-type rats, 5×106 GFP-expressing SMB or PBS only (control) were injected via either the intramyocardial or retrograde intracoronary routes. Injection of SMB via either route similarly improved cardiac performance and physical activity, associated with reduced cardiomyocyte-hypertrophy and fibrosis. Grafted SMB via either route were only present in low numbers in the myocardium, analysed by real-time PCR for the Y-chromosome specific gene, Sry. Cardiomyogenic differentiation of grafted SMB was extremely rare. Continuous ECG monitoring by telemetry revealed that only intramyocardial injection of SMB produced spontaneous ventricular tachycardia up to 14 days, associated with local myocardial heterogeneity generated by clusters of injected SMB and accumulated inflammatory cells. A small number of ventricular premature contractions with latent ventricular tachycardia were detected in the late-phase of SMB injection regardless of the injection-route.ConclusionRetrograde intracoronary injection of SMB provided significant therapeutic benefits with attenuated early-phase arrhythmogenicity in treating ischaemic cardiomyopathy, indicating the promising utility of this route for SMB-delivery. Late-phase arrhythmogenicity remains a concern, regardless of the delivery route.
Birks EJ, Latif N, Enesa K, et al., 2008, Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy, CARDIOVASCULAR RESEARCH, Vol: 79, Pages: 472-480, ISSN: 0008-6363
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- Citations: 92
Soppa GKR, Lee J, Stagg MA, et al., 2008, Prolonged mechanical unloading reduces myofilament sensitivity to calcium and sarcoplasmic reticulum calcium uptake leading to contractile dysfunction, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 27, Pages: 882-889, ISSN: 1053-2498
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- Citations: 30
Soppa GKR, Barton PJR, Terracciano CMN, et al., 2008, Left ventricular assist device-induced molecular changes in the failing myocardium, CURRENT OPINION IN CARDIOLOGY, Vol: 23, Pages: 206-218, ISSN: 0268-4705
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- Citations: 29
Soppa GKR, Lee J, Stagg MA, et al., 2008, Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure, Cardiovascular Research, Vol: 77, Pages: 695-706, ISSN: 1755-3245
AimsCombined left ventricular assist device (LVAD) and pharmacological therapy has been proposed to favour myocardial recovery in patients with end-stage heart failure (HF). Clenbuterol (Clen), a β2-adrenoceptor (β2-AR) agonist, has been used as a part of this strategy. In this study, we investigated the direct effects of clenbuterol on unloaded myocardium in HF.Methods and resultsLeft coronary artery ligation or sham operation was performed in male Lewis rats. After 4–6 weeks, heterotopic abdominal transplantation of the failing hearts into normal recipients was performed to induce LV unloading (UN). Recipient rats were treated with saline (Sal) or clenbuterol (2 mg/kg/day) via osmotic minipumps (HF + UN + Sal or HF + UN + Clen) for 7 days. Non-transplanted HF animals were treated with Sal (Sham + Sal, HF + Sal) or clenbuterol (HF + Clen). LV myocytes were isolated and studied using optical, fluorescence, and electrophysiological techniques. Clenbuterol treatment improved in vivo LV function measured with echocardiography (LVEF (%): HF 35.9 ± 2 [16], HF + Clen 52.1 ± 1.4 [16]; P < 0.001; mean ± SEM [n]). In combination with unloading, clenbuterol increased sarcomere shortening (amplitude (µm): HF + UN + Clen 0.1 ± 0.01 [50], HF + UN + Sal 0.07 ± 0.01 [38]; P < 0.001) by normalizing the depressed myofilament sensitivity to Ca2+ (slope of the linear relationship between Ca2+ transient and sarcomere shortening hysteresis loop during relaxation (μm/ratio unit): HF + UN + Clen 2.13 ± 0.2 [52], HF + UN + Sal 1.42 ± 0.13 [38]; P < 0.05).ConclusionClenbuterol treatment of failing rat hearts, alone or in combination with mechanical unloading, improves LV function at the whole-heart and cellular levels by affecting cell morphology, excitation–contraction coupling, and myofilament sensitivity to calcium. This study supports the use of this drug in the strategy to enhance recovery in HF pa
Terracciano CMN, Payne J, Harding SE, et al., 2008, Human embryonic stem cell-derived cardiomyocytes as a model for assessing HERG channel blockade, Autumn Meeting of the British-Society-for-Cardiovascular-Research, Publisher: BMJ PUBLISHING GROUP, ISSN: 1355-6037
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- Citations: 1
Suzuki K, Fukushima S, Varela-Carver A, et al., 2007, Response to letter regarding article, "Direct Intramyocardial but Not Intracoronary Injection of Bone Marrow Cells Induces Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model", CIRCULATION, Vol: 116, Pages: E555-E555, ISSN: 0009-7322
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- Citations: 2
Terracciano CM, Sohrabl N, Siedlecka U, et al., 2007, Cytoskeletal protein 4.1R affects repolarisation and regulates calcium handling in the heart, 80th Annual Scientific Session of the American-Heart-Association, Pages: 216-217
Slominska EM, Orlewska C, Terracciano CM, et al., 2007, Endothelial and cardiomyocyte toxicity of endogenously produced nucleoside:: 4-pyridone-3-carboxamide-1-β-d-riboside, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 296-297, ISSN: 0009-7322
Stagg MA, Lee J, Siedlecka U, et al., 2007, Effects of adult progenitor cell transplantation on unitary sarcoplasmic reticulum calcium release events in failing recipient cardiomyocytes, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 592-592, ISSN: 0009-7322
Siedlecka U, Arora M, Soppa GK, et al., 2007, Unlike other beta2-adrenoceptor agonists, clenbuterol predominantly activates the Gi protein in isolated rat ventricular myocytes, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 50-50, ISSN: 0195-668X
Farkasfalvi K, Stagg MA, Coppen SR, et al., 2007, Direct effects of apelin on cardiomyocyte contractility and electrophysiology, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 357, Pages: 889-895, ISSN: 0006-291X
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- Citations: 122
Lee J, Siedlecka U, Stagg M, et al., 2007, Skeletal myoblasts and bone marrow cells enhance contractility of failing cardiomyocytes in co-culture, 19th World Congress of the International-Society-for-Heart-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: S100-S100, ISSN: 0022-2828
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- Citations: 1
Stagg MA, Patel NG, Siedlecka U, et al., 2007, The effects of β<sub>2</sub>-adrenoceptor agonists on conduction velocity, field potentials and automaticity in cardiomyocytes, 19th World Congress of the International-Society-for-Heart-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: S25-S25, ISSN: 0022-2828
Siedlecka U, Arora M, Soppa GKR, et al., 2007, Clenbuterol affects rat ventricular myocyie contractility via an inhibitory G protein-mediated pathway, 19th World Congress of the International-Society-for-Heart-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: S49-S49, ISSN: 0022-2828
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- Citations: 2
Soppa GKR, Latif N, Lee J, et al., 2007, Clenbuterol prevents G<sub>αi</sub> protein reduction induced by mechanical unloading in failing cardiomyocytes, 19th World Congress of the International-Society-for-Heart-Research, Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Pages: S152-S152, ISSN: 0022-2828
Fukushima S, Varela-Carver A, Coppen SR, et al., 2007, Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model, CIRCULATION, Vol: 115, Pages: 2254-2261, ISSN: 0009-7322
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- Citations: 152
Terracciano CMN, Koban MU, Soppa GK, et al., 2007, The role of the cardiac Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchanger in reverse remodeling -: Relevance for LVAD-recovery, SODIUM-CALCIUM EXCHANGE AND THE PLASMA MEMBRANE CA2+-ATPASE IN CELL FUNCTION: FIFTH INTERNATIONAL CONFERENCE, Vol: 1099, Pages: 349-360, ISSN: 0077-8923
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- Citations: 16
Terracciano CMN, Koban M, Soppa G, et al., 2007, The role of the Cardiac Na/CA exchanger in Reverse Remodeling, Boston, Fifth International Conference on Sodium-calcium exchanger, Publisher: Blackwell Publishing, Pages: 349-360
Farkasfalvi K, Felkin L, Latif N, et al., 2006, The apelin receptor mRNA levels and myocardial recovery in end-stage heart failure patients treated with left ventricular assist devices (LVADs), 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 484-484, ISSN: 0009-7322
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- Citations: 1
Lee J, Stagg MA, Soppa GK, et al., 2006, Skeletal myoblasts and bone marrow-derived cells enhance the contractile function of isolated failing cardiomyocytes in co-culture, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 93-93, ISSN: 0009-7322
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- Citations: 1
Farkasfalvi K, Stagg MA, Siedlecka U, et al., 2006, Apelin, the ligand for the angiotensin receptor-like 1, directly affects cardiomyocyte contractility and electrophysiology, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 300-300, ISSN: 0009-7322
Soppa GK, Lee J, Stagg MA, et al., 2006, Chronic clenbuterol treatment improves heart and myocyte function in heart failure, with and without mechanical unloading., 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 483-483, ISSN: 0009-7322
Felkin LE, Farkasfalvi K, Soppa GKR, et al., 2006, The apelin-angiotensin receptor-like 1 (APJ) mRNA levels closely correlate with myocardial recovery in end-stage heart failure patients treated with left ventricular assist devices (LVADs), 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 267-267, ISSN: 0195-668X
Soppa GKR, Lee J, Stagg MA, et al., 2006, Influence of clenbuterol and unloading on myocardial cell contractile dysfunction and calcium homeostasis in early heart failure, 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 408-408, ISSN: 0195-668X
Farkasfalvi K, Stagg MA, Siedlecka U, et al., 2006, Direct effects of apelin, the ligand for the angiotensin receptor-like 1, on cardiomyocyte contractility and electrophysiology, 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 407-407, ISSN: 0195-668X
Lee J, Fukushima S, Stagg MA, et al., 2006, Paracrine effects of cell transplantation on recipient cardiomyocytes in a rat model of heart failure, 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 19-19, ISSN: 0195-668X
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