Imperial College London

ProfessorChristoferToumazou

Faculty of EngineeringDepartment of Electrical and Electronic Engineering

Winston Wong Chair, Biomedical Circuits
 
 
 
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Contact

 

+44 (0)20 7594 6255c.toumazou

 
 
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Assistant

 

Miss Gifty Kugblenu +44 (0)20 7594 6168

 
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Location

 

405Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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460 results found

Pesl P, Herrero P, Reddy M, Oliver N, Johnston DG, Toumazou C, Georgiou Pet al., 2017, Case-Based Reasoning for Insulin Bolus Advice., J Diabetes Sci Technol, Vol: 11, Pages: 37-42

BACKGROUND: Insulin bolus calculators assist people with Type 1 diabetes (T1D) to calculate the amount of insulin required for meals to achieve optimal glucose levels but lack adaptability and personalization. We have proposed enhancing bolus calculators by the means of case-based reasoning (CBR), an established problem-solving methodology, by individualizing and optimizing insulin therapy for various meal situations. CBR learns from experiences of past similar meals, which are described in cases through a set of parameters (eg, time of meal, alcohol, exercise). This work discusses the selection, representation and effect of case parameters used for a CBR-based Advanced Bolus Calculator for Diabetes (ABC4D). METHODS: We analyzed the usage and effect of selected parameters during a pilot study (n = 10), where participants used ABC4D for 6 weeks. Retrospectively, we evaluated the effect of glucose rate of change before the meal on the glycemic excursion. Feedback from study participants about the choice of parameters was obtained through a nonvalidated questionnaire. RESULTS: Exercise and alcohol were the most frequently used parameters, which was congruent with the feedback from study participants, who found these parameters most useful. Furthermore, cases including either exercise or alcohol as parameter showed a trend in reduction of insulin at the end of the study. A significant difference ( P < .01) was found in glycemic outcomes for meals where glucose rate of change was rising compared to stable rate of change. CONCLUSIONS: Results from the 6-week study indicate the potential benefit of including parameters exercise, alcohol and glucose-rate of change for insulin dosing decision support.

JOURNAL ARTICLE

El Sharkawy M, Herrero P, Reddy M, Pesl P, Georgiou P, Johnston D, Oliver N, Toumazou C, Seechurn SB, Jugnee N, Pavitt DVet al., 2016, A LOW-POWER BIO-INSPIRED ARTIFICIAL PANCREAS, Publisher: MARY ANN LIEBERT, INC, Pages: A54-A54, ISSN: 1520-9156

CONFERENCE PAPER

Herrero P, Bondia J, Amparo G, Oliver N, Toumazou C, Georgiou Pet al., 2016, A BIHORMONAL GLUCOSE CONTROLLER BASED ON THE PARACRINE INTERACTION BETWEEN BETA CELL AND ALPHA CELL, Publisher: MARY ANN LIEBERT, INC, Pages: A57-A58, ISSN: 1520-9156

CONFERENCE PAPER

Herrero P, Delaunay B, Jaulin L, Georgiou P, Oliver N, Toumazou Cet al., 2016, Robust set-membership parameter estimation of the glucose minimal model, INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING, Vol: 30, Pages: 173-185, ISSN: 0890-6327

JOURNAL ARTICLE

Pesl P, Herrero P, Reddy M, Oliver N, Johnston D, Toumazou C, Georgiou Pet al., 2016, GLUCOSE RATE-OF-CHANGE AT MEAL TIMES FOR INSULIN DOSING DECISION SUPPORT, Publisher: MARY ANN LIEBERT, INC, Pages: A97-A97, ISSN: 1520-9156

CONFERENCE PAPER

Pesl P, Herrero P, Reddy M, Oliver N, Johnston D, Toumazou C, Georgiou Pet al., 2016, AUGMENTING AN ADVANCED BOLUS CALCULATOR WITH CONTINUOUS GLUCOSE MONITORING AND A SMARTWATCH, Publisher: MARY ANN LIEBERT, INC, Pages: A97-A97, ISSN: 1520-9156

CONFERENCE PAPER

Pesl P, Herrero P, Reddy M, Xenou M, Oliver N, Johnston D, Toumazou C, Georgiou Pet al., 2016, An Advanced Bolus Calculator for Type 1 Diabetes: System Architecture and Usability Results, IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, Vol: 20, Pages: 11-17, ISSN: 2168-2194

JOURNAL ARTICLE

Reddy M, Pesl P, Xenou M, Toumazou C, Johnston D, Georgiou P, Herrero P, Oliver Net al., 2016, Clinical Safety and Feasibility of the Advanced Bolus Calculator for Type 1 Diabetes Based on Case-Based Reasoning: A 6-Week Nonrandomized Single-Arm Pilot Study, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 18, Pages: 487-493, ISSN: 1520-9156

JOURNAL ARTICLE

Reddy M, Pesl P, Xenou M, Toumazou C, Johnston D, Georgiou P, Herrero P, Oliver Net al., 2016, CLINICAL SAFETY AND FEASIBILITY OF THE ADVANCED BOLUS CALCULATOR FOR TYPE 1 DIABETES BASED ON CASE-BASED REASONING: A 6-WEEK NON-RANDOMISED SINGLE-ARM PILOT STUDY, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 18, Pages: A34-A35, ISSN: 1520-9156

JOURNAL ARTICLE

Seechurn S, Reddy M, Jugnee N, El Sharkawy M, Hesl P, Herrero-Vinias P, Godsland I, Toumazou C, Pantelis G, Oliver Net al., 2016, DOES THE ADDITION OF GLUCAGON TO A CLOSED LOOP SYSTEM IMPACT ON POST EXERCISE GLYCAEMIA?, Publisher: MARY ANN LIEBERT, INC, Pages: A60-A61, ISSN: 1520-9156

CONFERENCE PAPER

Zuliani C, Ng FS, Alenda A, Eftekhar A, Peters NS, Toumazou Cet al., 2016, An array of individually addressable micro-needles for mapping pH distributions, ANALYST, Vol: 141, Pages: 4659-4666, ISSN: 0003-2654

JOURNAL ARTICLE

Hernandez-Silveira M, Ahmed K, Ang S-S, Zandari F, Mehta T, Weir R, Burdett A, Toumazou C, Brett SJet al., 2015, Assessment of the feasibility of an ultra-low power, wireless digital patch for the continuous ambulatory monitoring of vital signs, BMJ OPEN, Vol: 5, ISSN: 2044-6055

JOURNAL ARTICLE

Herrero P, Chen Z, Bondia J, Georgiou P, Toumazou C, Schaschkow Aet al., 2015, INTERVAL-BASED MODEL PREDICTIVE CONTROL FOR AN ARTIFICIAL PANCREAS, Publisher: MARY ANN LIEBERT, INC, Pages: A99-A99, ISSN: 1520-9156

CONFERENCE PAPER

Herrero P, Pesl P, Bondia J, Reddy M, Oliver N, Georgiou P, Toumazou Cet al., 2015, Method for automatic adjustment of an insulin bolus calculator: In silico robustness evaluation under intra-day variability, COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, Vol: 119, Pages: 1-8, ISSN: 0169-2607

JOURNAL ARTICLE

Herrero P, Pesl P, Reddy M, Oliver N, Georgiou P, Toumazou Cet al., 2015, Advanced Insulin Bolus Advisor Based on Run-To-Run Control and Case-Based Reasoning, IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, Vol: 19, Pages: 1087-1096, ISSN: 2168-2194

JOURNAL ARTICLE

Paraskevopoulou SE, Eftekhar A, Kulasekeram N, Toumazou Cet al., 2015, A Low-Noise Instrumentation Amplifier with DC Suppression for Recording ENG Signals, 2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), Pages: 2693-2696, ISSN: 1557-170X

JOURNAL ARTICLE

Pesl P, Herrero P, Reddy M, Xenou M, Jugnee N, Oliver N, Johnston D, Toumazou C, Georgiou Pet al., 2015, ACCEPTABILITY OF A PATIENT AND CLINICAL PLATFORM OF AN ADVANCED BOLUS CALCULATOR FOR TYPE 1 DIABETES (ABC4D), Publisher: MARY ANN LIEBERT, INC, Pages: A130-A130, ISSN: 1520-9156

CONFERENCE PAPER

Reddy M, Herrero P, El Sharkawy M, Pesl P, Jugnee N, Godsland I, Toumazou C, Johnston D, Georgiou P, Oliver Net al., 2015, METABOLIC CONTROL WITH THE BIO-INSPIRED ARTIFICIAL PANCREAS (BIAP) IN ADULTS WITH TYPE 1 DIABETES: A 24-HOUR RANDOMISED CONTROLLED CROSSOVER STUDY, Publisher: MARY ANN LIEBERT, INC, Pages: A20-A21, ISSN: 1520-9156

CONFERENCE PAPER

Reddy M, Herrero P, El Sharkawy M, Pesl P, Jugnee N, Pavitt D, Toumazou C, Johnston D, Georgiou P, Oliver Net al., 2015, CLINICAL EVALUATION OF THE BIO-INSPIRED ARTIFICIAL PANCREAS (BIAP) WITHOUT MEAL ANNOUNCEMENT IN ADULTS WITH TYPE 1 DIABETES, Publisher: MARY ANN LIEBERT, INC, Pages: A45-A46, ISSN: 1520-9156

CONFERENCE PAPER

Reddy M, Pesl P, Xenou M, Jugnee N, Toumazou C, Johnston D, Georgiou P, Herrero P, Oliver Net al., 2015, CLINICAL SAFETY EVALUATION OF AN ADVANCED BOLUS CALCULATOR FOR TYPE 1 DIABETES (ABC4D), Publisher: MARY ANN LIEBERT, INC, Pages: A130-A131, ISSN: 1520-9156

CONFERENCE PAPER

Sohbati M, Toumazou C, 2015, Dimension and Shape Effects on the ISFET Performance, IEEE SENSORS JOURNAL, Vol: 15, Pages: 1670-1679, ISSN: 1530-437X

JOURNAL ARTICLE

Eftekhar A, Juffali W, El-Imad J, Constandinou TG, Toumazou Cet al., 2014, Ngram-Derived Pattern Recognition for the Detection and Prediction of Epileptic Seizures, PLOS ONE, Vol: 9, ISSN: 1932-6203

JOURNAL ARTICLE

Herrero P, El Sharkawy M, Pesl P, Reddy M, Oliver N, Johnston D, Toumazou C, Georgiou Pet al., 2014, Live Demonstration: A Handheld Bio-inspired Artificial Pancreas for Treatment of Diabetes, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 172-172, ISSN: 2163-4025

CONFERENCE PAPER

Herrero P, Liu C, Georgiou P, Oliver N, El Sharkawy A, Pesl P, Reddy M, Johnston D, Toumazou Cet al., 2014, HYPOGLYCEMIA PREDICTION BASED ON EXTENDED KALMAN FILTER USING A PHYSIOLOGICAL MODEL OF GLUCOSE REGULATION, Publisher: MARY ANN LIEBERT, INC, Pages: A82-A83, ISSN: 1520-9156

CONFERENCE PAPER

Kalofonou M, Toumazou C, 2014, A Low Power Sub-mu W Chemical Gilbert Cell for ISFET Differential Reaction Monitoring, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 8, Pages: 565-574, ISSN: 1932-4545

JOURNAL ARTICLE

Kalofonou M, Toumazou C, 2014, An ISFET based analogue ratiometric method for DNA methylation detection, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 1832-1835, ISSN: 0271-4302

CONFERENCE PAPER

Lang Z, Gurrala R, Kaye S, Toumazou C, Cooke Get al., 2014, POC diagnostic test for HLA B(star)5701 using pH-based label-free detection, HIV MEDICINE, Vol: 15, Pages: 71-71, ISSN: 1464-2662

JOURNAL ARTICLE

Murphy OH, Borghi A, Bahmanyar MR, McLeod CN, Navaratnarajah M, Yacoub M, Toumazou Cet al., 2014, RF communication with implantable wireless device: effects of beating heart on performance of miniature antenna., Healthc Technol Lett, Vol: 1, Pages: 51-55, ISSN: 2053-3713

The frequency response of an implantable antenna is key to the performance of a wireless implantable sensor. If the antenna detunes significantly, there are substantial power losses resulting in loss of accuracy. One reason for detuning is because of a change in the surrounding environment of an antenna. The pulsating anatomy of the human heart constitutes such a changing environment, so detuning is expected but this has not been quantified dynamically before. Four miniature implantable antennas are presented (two different geometries) along with which are placed within the heart of living swine the dynamic reflection coefficients. These antennas are designed to operate in the short range devices frequency band (863-870 MHz) and are compatible with a deeply implanted cardiovascular pressure sensor. The measurements recorded over 27 seconds capture the effects of the beating heart on the frequency tuning of the implantable antennas. When looked at in the time domain, these effects are clearly physiological and a combination of numerical study and posthumous autopsy proves this to be the case, while retrospective simulation confirms this hypothesis. The impact of pulsating anatomy on antenna design and the need for wideband implantable antennas is highlighted.

JOURNAL ARTICLE

Pagkalos I, Herrero P, Toumazou C, Georgiou Pet al., 2014, Bio-Inspired Glucose Control in Diabetes Based on an Analogue Implementation of a beta-Cell Model, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 8, Pages: 186-195, ISSN: 1932-4545

JOURNAL ARTICLE

Pesl P, Herrero P, Reddy M, Oliver N, Johnston D, Toumazou C, Georgiou Pet al., 2014, Live Demonstration: An Advanced Bolus Calculator for Diabetes Management - A Clinical and Patient Platform, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 175-175, ISSN: 2163-4025

CONFERENCE PAPER

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