Imperial College London
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ProfessorChristoferToumazou

Faculty of Engineering, Department of Electrical and Electronic Engineering

Winston Wong Chair, Biomedical Circuits
 
 
 
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Contact

 

+44 (0)20 7594 6255c.toumazou

 
 
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Assistant

 

Mrs Gifty Osei-Ansah +44 (0)20 7594 6168

 
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Location

 

405Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Reddy:2016:10.1089/dia.2015.0413,
author = {Reddy, M and Pesl, P and Xenou, M and Toumazou, C and Johnston, D and Georgiou, P and Herrero, P and Oliver, N},
doi = {10.1089/dia.2015.0413},
journal = {Diabetes Technol Ther},
pages = {487--493},
title = {Clinical Safety and Feasibility of the Advanced Bolus Calculator for Type 1 Diabetes Based on Case-Based Reasoning: A 6-Week Nonrandomized Single-Arm Pilot Study.},
url = {http://dx.doi.org/10.1089/dia.2015.0413},
volume = {18},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The Advanced Bolus Calculator for Diabetes (ABC4D) is an insulin bolus dose decision support system based on case-based reasoning (CBR). The system is implemented in a smartphone application to provide personalized and adaptive insulin bolus advice for people with type 1 diabetes. We aimed to assess proof of concept, safety, and feasibility of ABC4D in a free-living environment over 6 weeks. METHODS: Prospective nonrandomized single-arm pilot study. Participants used the ABC4D smartphone application for 6 weeks in their home environment, attending the clinical research facility weekly for data upload, revision, and adaptation of the CBR case base. The primary outcome was postprandial hypoglycemia. RESULTS: Ten adults with type 1 diabetes, on multiple daily injections of insulin, mean (standard deviation) age 47 (17), diabetes duration 25 (16), and HbA1c 68 (16) mmol/mol (8.4 (1.5) %) participated. A total of 182 and 150 meals, in week 1 and week 6, respectively, were included in the analysis of postprandial outcomes. The median (interquartile range) number of postprandial hypoglycemia episodes within 6-h after the meal was 4.5 (2.0-8.2) in week 1 versus 2.0 (0.5-6.5) in week 6 (P = 0.1). No episodes of severe hypoglycemia occurred during the study. CONCLUSION: The ABC4D is safe for use as a decision support tool for insulin bolus dosing in self-management of type 1 diabetes. A trend suggesting a reduction in postprandial hypoglycemia was observed in the final week compared with week 1.
AU  - Reddy,M
AU  - Pesl,P
AU  - Xenou,M
AU  - Toumazou,C
AU  - Johnston,D
AU  - Georgiou,P
AU  - Herrero,P
AU  - Oliver,N
DO  - 10.1089/dia.2015.0413
EP  - 493
PY  - 2016///
SP  - 487
TI  - Clinical Safety and Feasibility of the Advanced Bolus Calculator for Type 1 Diabetes Based on Case-Based Reasoning: A 6-Week Nonrandomized Single-Arm Pilot Study.
T2  - Diabetes Technol Ther
UR  - http://dx.doi.org/10.1089/dia.2015.0413
UR  - https://www.ncbi.nlm.nih.gov/pubmed/27196358
UR  - http://hdl.handle.net/10044/1/39151
VL  - 18
ER  -
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