DrCarolinaHerrera

Faculty of Medicine, Department of Infectious Disease

Honorary Senior Research Fellow

Contact

Location

460 (Shattock Group)Medical SchoolSt Mary's Campus

Summary

I am a Senior Research Fellow in the Section of Immunology of Infection. I obtained my BSc in Chemistry and my PhD in Biochemistry, working on the role of adenosine and adenosine deaminase in immunodeficiencies, at the University of Barcelona, Spain. I then joined the group of Prof. John P. Moore at the Weill Medical College of Cornell University, New York, USA. As a Postdoctoral Fellow, I had the opportunity to make my first steps in the field of HIV working in the areas of neutralizing antibodies and CCR5 co-receptor.

My primary research interests are mucosal infection and inflammation. Using ex vivo tissue models, I study mucosal responses during transmission of HIV/SIV, HCV, and Zika virus. These primary tissue models also allow pre-clinical evaluation of prevention strategies, including pre-exposure prophylaxis and vaccine candidates. I have recently expanded the potential of the ex vivo tissue models to investigate inflammation and associated pathologies such as Inflammatory Bowel Disease.

During the last 10 years, I have been funded as PI or co-investigator by amfAR, HVTN-CHAVI, EU Commission FP7 Health 2012 Innovation, EDCTP, NIH, Canadian Institute for Health Research, Manitoba Health Research, Henry Jackson Foundation, Pfizer, Gilead, Merck and CHAIN Biotechnology.

Publications

Journals

Gordhan BG, Herrera C, Pillay A-D, et al.Gordhan BG, Herrera C, Pillay A-D, Seiphetlo T, Ealand CS, Machowski E, Singh N, Seatholo N, Otwombe K, Lebina L, Frise R, Scarlatti G, Chiodi F, Martinson N, Fox J, Kana BD close, 2023, Evaluation of a human mucosal tissue explant model for SARS-CoV-2 replication, Plos One, Vol:18, ISSN:1932-6203

Rametse CL, Webb E, Herrera C, et al.Rametse CL, Webb E, Herrera C, Alinde B, Besethi A, Motaung B, Mbangiwa T, Leach L, Sebaa S, Pillay A-DAPB, Seiphetlo T, Malhangu B, Petkov S, Else L, Mugaba S, Namubiru P, Odoch G, Opoka D, Serwanga JS, Ssemata A, Kaleebu P, Khoo S, Lebina L, Martinson N, Chiodi F, Fox JM, Gray C, CHAPS C close, 2023, A randomized clinical trial of on-demand oral pre-exposure prophylaxis does not modulate lymphoid/myeloid HIV target cell density in the foreskin, Aids, Vol:37, ISSN:0269-9370, Pages:1651-1659

Berard A, Lajoie J, Herrera C, 2023, Editorial: Inflammation in the female genital tract, Frontiers in Reproductive Health, Vol:5

Martinson N, Gordhan B, Petkov S, et al.Martinson N, Gordhan B, Petkov S, Pillay A-D, Seiphetlo T, Singh N, Otwombe K, Lebina L, Fredolini C, Chiodi F, Fox J, Kana B, Herrera C close, 2023, Proteomic analysis of mucosal and systemic responses to SARS-CoV-2 antigen, Vaccines, Vol:11, ISSN:2076-393X, Pages:1-15

Abdool Karim Q, Archary D, Barré-Sinoussi F, et al.Abdool Karim Q, Archary D, Barré-Sinoussi F, Broliden K, Cabrera C, Chiodi F, Fidler S, Gengiah T, Herrera C, KHARSANY A, Liebenberg L, Mahomed S, Menu E, Moog C, Scarlatti G, Seddiki N, Sivro A, Cavarelli M close, 2022, Women for science and science for women: Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention, Frontiers in Immunology, Vol:13, ISSN:1664-3224, Pages:1-21

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