Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Professor of Cancer Biology



charlotte.bevan Website




Mrs Suzy Ford +44 (0)20 7594 2135




139ICTEM buildingHammersmith Campus






BibTex format

author = {Jarvis, S and Williamson, C and Bevan, C},
doi = {10.3390/ijms20215379},
journal = {International Journal of Molecular Sciences},
title = {Liver X receptors and male (in)fertility},
url = {},
volume = {20},
year = {2019}

RIS format (EndNote, RefMan)

AB - Liver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed predominantly in metabolically active tissues and the latter more ubiquitously. Both are activated by oxidised cholesterol metabolites, endogenously produced oxysterols. LXRs have important roles in lipid metabolism and inflammation, plus a number of newly emerging roles. They are implicated in regulating lipid balance in normal male reproductive function and may provide a link between male infertility and lipid disorders and/or obesity. Studies from Lxr knockout mouse models provide compelling evidence to support this. More recently published data suggest distinct and overlapping roles of the LXR isoforms in the testis and recent evidence of a role for LXRs in human male fertility. This review summarises the current literature and explores the likely link between LXR, lipid metabolism and male fertility as part of a special issue on Liver X receptors in International Journal of Molecular Sciences.
AU - Jarvis,S
AU - Williamson,C
AU - Bevan,C
DO - 10.3390/ijms20215379
PY - 2019///
SN - 1422-0067
TI - Liver X receptors and male (in)fertility
T2 - International Journal of Molecular Sciences
UR -
UR -
VL - 20
ER -