Imperial College London

ProfessorCharlotteBevan

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Cancer Biology
 
 
 
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Contact

 

charlotte.bevan Website

 
 
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Assistant

 

Mrs Suzy Ford +44 (0)20 7594 2135

 
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Location

 

139ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bevan:2016:nar/gkw938,
author = {Bevan, CL and Fletcher, CE and Godfrey, JD and Shibakawa, A and Bushell, M},
doi = {nar/gkw938},
journal = {Nucleic Acid Research},
pages = {2809--2828},
title = {A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis},
url = {http://dx.doi.org/10.1093/nar/gkw938},
volume = {45},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here, we identify the kinase GSK3ß as a important modulator of miR biogenesis at Microprocessor level. Repression of GSK3ß activity reduces Drosha activity towards pri-miRs, leading to accumulation of unprocessed pri-miRs and reduction of mature pri-miRs without altering levels or cellular locations of miR biogenesis proteins...
AU - Bevan,CL
AU - Fletcher,CE
AU - Godfrey,JD
AU - Shibakawa,A
AU - Bushell,M
DO - nar/gkw938
EP - 2828
PY - 2016///
SN - 2159-3345
SP - 2809
TI - A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis
T2 - Nucleic Acid Research
UR - http://dx.doi.org/10.1093/nar/gkw938
UR - http://hdl.handle.net/10044/1/41279
VL - 45
ER -