Imperial College London
Alternate

ProfessorCharlotteBevan

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cancer Biology
 
 
 
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Contact

 

charlotte.bevan Website

 
 
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Assistant

 

Mrs Suzy Ford +44 (0)20 7594 2135

 
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Location

 

139ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Leach:2021:10.1042/EBC20210005,
author = {Leach, DA and Brooke, GN and Bevan, CL},
doi = {10.1042/EBC20210005},
journal = {Essays in Biochemistry},
pages = {1025--1038},
title = {Roles of steroid receptors in the lung and COVID-19},
url = {http://dx.doi.org/10.1042/EBC20210005},
volume = {65},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - COVID-19 symptoms and mortality are largely due to its devastating effects in the lungs. The disease is caused by the SARS (Severe Acute Respiratory Syndrome)-CoV-2 coronavirus, which requires host cell proteins such as ACE2 (angiotensin-converting enzyme 2) and TMPRSS2 (transmembrane serine protease 2) for infection of lung epithelia. The expression and function of the steroid hormone receptor family is important in many aspects that impact on COVID-19 effects in the lung – notably lung development and function, the immune system, and expression of TMPRSS2 and ACE2. This review provides a brief summary of current knowledge on the roles of the steroid hormone receptors [androgen receptor (AR), glucocorticoid receptor (GR), progesterone receptor (PR), mineralocorticoid receptor (MR) and oestrogen receptor (ER)] in the lung, their effects on host cell proteins that facilitate SARS-CoV-2 uptake, and provides a snapshot of current clinical trials investigating the use of steroid receptor (SR) ligands to treat COVID-19.
AU  - Leach,DA
AU  - Brooke,GN
AU  - Bevan,CL
DO  - 10.1042/EBC20210005
EP  - 1038
PY  - 2021///
SN  - 0071-1365
SP  - 1025
TI  - Roles of steroid receptors in the lung and COVID-19
T2  - Essays in Biochemistry
UR  - http://dx.doi.org/10.1042/EBC20210005
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000726353600015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://portlandpress.com/essaysbiochem/article/65/6/1025/229422/Roles-of-steroid-receptors-in-the-lung-and-COVID
UR  - http://hdl.handle.net/10044/1/98547
VL  - 65
ER  -
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