Imperial College London
Alternate

ProfessorCharlotteBevan

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cancer Biology
 
 
 
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Contact

 

charlotte.bevan Website

 
 
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Assistant

 

Mrs Suzy Ford +44 (0)20 7594 2135

 
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Location

 

139ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gethings:2017:10.1002/rcm.7941,
author = {Gethings, LA and Richardson, K and Wildgoose, J and Lennon, S and Jarvis, S and Bevan, CL and Vissers, JPC and Langridge, JI},
doi = {10.1002/rcm.7941},
journal = {Rapid Communications in Mass Spectrometry},
pages = {1599--1606},
title = {Lipid profiling of complex biological mixtures by liquid chromatography/mass spectrometry using a novel scanning quadrupole data-independent acquisition strategy},
url = {http://dx.doi.org/10.1002/rcm.7941},
volume = {31},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - RationaleA novel data-independent acquisition method is detailed that incorporates a scanning quadrupole in front of an orthogonal acceleration time-of-flight (TOF) mass analyser. This approach is described and the attributes are compared and contrasted to other DIA approaches.MethodsSpecific application of the method to both targeted and untargeted lipidomic identification strategies is discussed, with data from both shotgun and LC separated lipidomics experiments presented.ResultsThe benefits of the fast quadrupole scanning technique are highlighted, and include improvements in speed and specificity for complex mixtures providing high quality qualitative and quantitative data.ConclusionsIn particular the high specificity afforded by the scanning quadrupole improves qualitative information for lipid identification.
AU  - Gethings,LA
AU  - Richardson,K
AU  - Wildgoose,J
AU  - Lennon,S
AU  - Jarvis,S
AU  - Bevan,CL
AU  - Vissers,JPC
AU  - Langridge,JI
DO  - 10.1002/rcm.7941
EP  - 1606
PY  - 2017///
SN  - 0951-4198
SP  - 1599
TI  - Lipid profiling of complex biological mixtures by liquid chromatography/mass spectrometry using a novel scanning quadrupole data-independent acquisition strategy
T2  - Rapid Communications in Mass Spectrometry
UR  - http://dx.doi.org/10.1002/rcm.7941
UR  - http://hdl.handle.net/10044/1/52532
VL  - 31
ER  -
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