Imperial College London
Portrait Picture

Professor Chris Dunsby

Faculty of Natural Sciences, Department of Physics

Professor of Biomedical Optics
 
 
 
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Contact

 

+44 (0)20 7594 7755christopher.dunsby Website

 
 
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Location

 

622Blackett LaboratorySouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Riemer:2023:10.1109/tmi.2022.3223554,
author = {Riemer, K and Toulemonde, M and Yan, J and Lerendegui, M and Stride, E and Weinberg, PD and Dunsby, C and Tang, M-X},
doi = {10.1109/tmi.2022.3223554},
journal = {IEEE Transactions on Medical Imaging},
pages = {1056--1067},
title = {Fast and selective super-resolution ultrasound in vivo with acoustically activated nanodroplets},
url = {http://dx.doi.org/10.1109/tmi.2022.3223554},
volume = {42},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Perfusion by the microcirculation is key to the development, maintenance and pathology of tissue. Its measurement with high spatiotemporal resolution is consequently valuable but remains a challenge in deep tissue. Ultrasound Localization Microscopy (ULM) provides very high spatiotemporal resolution but the use of microbubbles requires low contrast agent concentrations, a long acquisition time, and gives little control over the spatial and temporal distribution of the microbubbles. The present study is the first to demonstrate Acoustic Wave Sparsely-Activated Localization Microscopy (AWSALM) and fast-AWSALM for in vivo super-resolution ultrasound imaging, offering contrast on demand and vascular selectivity. Three different formulations of acoustically activatable contrast agents were used. We demonstrate their use with ultrasound mechanical indices well within recommended safety limits to enable fast on-demand sparse activation and destruction at very high agent concentrations. We produce super-localization maps of the rabbit renal vasculature with acquisition times between 5.5 s and 0.25 s, and a 4-fold improvement in spatial resolution. We present the unique selectivity of AWSALM in visualizing specific vascular branches and downstream microvasculature, and we show super-localized kidney structures in systole (0.25 s) and diastole (0.25 s) with fast-AWSALM outdoing microbubble based ULM. In conclusion, we demonstrate the feasibility of fast and selective measurement of microvascular dynamics in vivo with subwavelength resolution using ultrasound and acoustically activatable nanodroplet contrast agents.
AU  - Riemer,K
AU  - Toulemonde,M
AU  - Yan,J
AU  - Lerendegui,M
AU  - Stride,E
AU  - Weinberg,PD
AU  - Dunsby,C
AU  - Tang,M-X
DO  - 10.1109/tmi.2022.3223554
EP  - 1067
PY  - 2023///
SN  - 0278-0062
SP  - 1056
TI  - Fast and selective super-resolution ultrasound in vivo with acoustically activated nanodroplets
T2  - IEEE Transactions on Medical Imaging
UR  - http://dx.doi.org/10.1109/tmi.2022.3223554
UR  - https://ieeexplore.ieee.org/document/9955557
UR  - http://hdl.handle.net/10044/1/101079
VL  - 42
ER  -
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