Imperial College London

DrClaireFletcher

Faculty of MedicineDepartment of Surgery & Cancer

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 2821claire.fletcher07 CV

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Summary

Post-Doctoral Career Development Fellow and Prostate Cancer Foundation Young Investigator.

My principal research interests lie in the field of small RNA and post-transcriptional regulation of gene expression in human disease. Specifically, I am interested in the mechanisms through which microRNAs ‘fine tune’ gene regulation, and how aberrations in these networks may contribute to disease. I am particularly intrigued by the regulatory mechanisms that govern microRNA biosynthesis, and by the huge potential of microRNA inhibitors/mimics to act as novel therapeutics in a wide array of conditions. Further interests include: microRNA ‘signatures’ as diagnostic or prognostic biomarkers, microRNA: long non-coding RNA (lncRNA) interaction networks, regulation of gene activity through alternative polyadenylation and RNA modifications, exosomal RNA-mediated communication mechanisms, and interplay between non-coding RNAs, nuclear receptors and DNA damage in cancer.

Ongoing projects:

  1.  Delineating Mechanisms of Post-Transcriptional Regulation of Wild-Type and Variant Androgen Receptors in Prostate Cancer for Therapeutic Intervention
  2. Exosomal Communication Between Peri-Prostatic Adipocytes and Epithelial Cells in Obesity-Driven Prostate Cancer
  3.  Kinase Modulators of MicroRNA Biogenesis
  4.  Apoptosis-modulating microRNA:target networks in drug-sensitive and -resistant breast cancer
  5.  Systematic Identification of MicroRNA Drivers of Resistance to Novel Therapeutics in Advanced Prostate Cancer – Exploitation as Stratification Biomarkers and Drug Targets
  6.   Functional Characterisation of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer
  7. MiR-346: lncRNA interactions link Androgen Receptor activity and DNA repair
  8.  Non-invasive microRNA signatures for predicting chemotherapy response in metastatic castration-resistant prostate cancer.

Publications:

  • Fletcher CE, Sulpice E, Coombe S, Guyon L, Hamilton M, Chrysostomou S, Leach D, Sharp A, Welti J, Yuan W, Dart DA, International SU2C/PCF Prostate Cancer Dream Team, Swain A, Lupold S, De Bono JS, McGuire SE, Gidrol X and Bevan C (2018). A Novel High-Throughput Screening Approach Identifies Androgen Receptor-Modulatory MicroRNAs and New Therapeutic Targets in Prostate Cancer  (submitted)
  • Fletcher CE (2017). AR-v7 liquid biopsy for treatment stratification in prostate cancer: how close are we? Current Opinion in Urology 27(5):500-509
  • Fletcher CE, Godfrey JD, Shibakawa A, Bushell M and Bevan CL (2017). A Novel Role for GSK3β as a Modulator of Drosha Microprocessor Activity and MicroRNA Biogenesis. Nucleic Acids Res. Mar 17; 45(5): 2809–2828
  • Fletcher CE, Dart DA and Bevan CL (2014): Interplay between Steroid Hormones and MicroRNAs: Implications for Hormone-Dependent Cancers. Endocrine-Related Cancer 21(5): R409-429.
  • Sita-Lumsden A#, Fletcher CE#, Dart DA, Brooke GN, Waxman J, Bevan CL (2013). Circulating nucleic acids as biomarkers of prostate cancer. Biomarkers in Medicine 7(6): 867-877. (# - joint first authors)
  • Frampton AE, Fletcher CE, Gall TMH, Krell J, Castellano L, Bevan CL, Stebbing J (2013): Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer. Expert Review Molecular Diagnostics 13(5): 425-430
  • Fletcher CE, Dart DA, Sita-Lumsden A, Cheng H, Rennie P and Bevan CL (2012): Androgen-regulated processing of the oncomir, miR-27a, which targets Prohibitin in prostate cancer. Hum. Mol. Genet. 21(14):3112-27.

 

Book Chapter:

  • Bevan CL, Fletcher CE, Sita-Lumsden A and Shibakawa A (2015, in press). Chapter 28: Circulating Nucleic Acids as Prostate Cancer Biomarkers. In: Garcia-Giménez JL ed. Epigenetic Biomarkers and Diagnostics. Elsevier.

 

Publications

Journals

Fletcher C, 2017, AR-v7 liquid biopsy for treatment stratification in prostate cancer: how close are we?, Current Opinion in Urology, Vol:27, ISSN:0963-0643, Pages:500-509

Fletcher CE, Godfrey JD, Shibakawa A, et al., 2017, A novel role for GSK3 beta as a modulator of Drosha microprocessor activity and MicroRNA biogenesis, Nucleic Acids Research, Vol:45, ISSN:0305-1048, Pages:2809-2828

Fletcher CE, Dart DA, Bevan CL, 2014, Interplay between steroid signalling and microRNAs: implications for hormone-dependent cancers, Endocrine-related Cancer, Vol:21, ISSN:1351-0088, Pages:R409-R429

Frampton AE, Fletcher CE, Gall TMH, et al., 2013, Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer, Expert Review of Molecular Diagnostics, Vol:13, ISSN:1473-7159, Pages:425-430

More Publications