Post-Doctoral Research Associate and Movember Fellow working in the lab of Prof Charlotte Bevan.
My research focuses on exploiting microRNAs (miRs) as treatment response and resistance biomarkers in advanced Castration-Resistant Prostate Cancer (CRPC). My work also investigates the use of miRs as therapeutics targets in prostate and breast cancers, and mechanisms by which biogenesis of miRs is perturbed in disease states. I am also interested in interactions between steroid hormone signaling and miRs.
- Fletcher CE and Bevan CL: GSK3β as a Modulator of MiR Biogenesis (in submission)
- Fletcher CE, Dart DA and Bevan CL (2014): Interplay between Steroid Hormones and MicroRNAs: Implications for Hormone-Dependent Cancers. Endocrine-Related Cancer 21(5): R409-429.
- Sita-Lumsden A#, Fletcher CE#, Dart DA, Brooke GN, Waxman J, Bevan CL (2013). Circulating nucleic acids as biomarkers of prostate cancer. Biomarkers in Medicine 7(6): 867-877. (# - joint first authors)
- Frampton AE, Fletcher CE, Gall TMH, Krell J, Castellano L, Bevan CL, Stebbing J (2013): Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer. Expert Review Molecular Diagnostics 13(5): 425-430
- Fletcher CE, Dart DA, Sita-Lumsden A, Cheng H, Rennie P and Bevan CL (2012): Androgen-regulated processing of the oncomir, miR-27a, which targets Prohibitin in prostate cancer. Hum. Mol. Genet. 21(14):3112-27.
- Bevan CL, Fletcher CE, Sita-Lumsden A and Shibakawa A (2015, in press). Chapter 28: Circulating Nucleic Acids as Prostate Cancer Biomarkers. In: Garcia-Giménez JL ed. Epigenetic Biomarkers and Diagnostics. Elsevier.
et al., 2017, A novel role for GSK3 beta as a modulator of Drosha microprocessor activity and MicroRNA biogenesis, Nucleic Acids Research, Vol:45, ISSN:0305-1048, Pages:2809-2828
Fletcher CE, Dart DA, Bevan CL, 2014, Interplay between steroid signalling and microRNAs: implications for hormone-dependent cancers, Endocrine-related Cancer, Vol:21, ISSN:1351-0088, Pages:R409-R429
et al., 2013, Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer, Expert Review of Molecular Diagnostics, Vol:13, ISSN:1473-7159, Pages:425-430
et al., 2013, Circulating nucleic acids as biomarkers of prostate cancer, Biomarkers in Medicine, Vol:7, ISSN:1752-0363, Pages:867-877