My research interests are in combing evolutionary theory and genomics to investigate genetic mechanisms underlying disease.
I earned my B.Sc. in Genetics and Cell Biology at Dublin City University, Ireland. Following a year working as a research technician at the University of Pennsylvania (UPENN), USA, I competed for and was awarded an IRCSET scholarship to pursue my PhD.
My doctoral work investigated the molecular adaptations in genes associated with aging and disease in placental mammals. I used heterogeneous models to identify the earliest diverging placental mammal as the ancestor to Afrotherians (e.g. Elephants and Manatees) and Xenartha (e.g. Armadillos and Sloths).
With a primary degree in genetics and PhD training in evolution, I moved to Imperial college to become expert in Next Generation Sequencing (NGS) analysis. Here as a postdoctoral researcher I combine evolutionary theory and genomics to pinpoint mutations in humans that give rise to disease such as diabetes and heart disease.
Moran R, Morgan C, O'Connell M, 2015, A Guide to Phylogenetic Reconstruction Using Heterogeneous Models—A Case Study from the Root of the Placental Mammal Tree, Computation, Vol:3, ISSN:2079-3197, Pages:177-196
et al., 2015, Adaptive Evolution as a Predictor of Species-Specific Innate Immune Response., Mol Biol Evol, Vol:32, Pages:1717-1729
et al., 2014, Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears., Cell, Vol:157, Pages:785-794
Morgan CC, Creevey CJ, O'Connell MJ, 2014, Mitochondrial data are not suitable for resolving placental mammal phylogeny, Mammalian Genome, Vol:25, ISSN:0938-8990, Pages:636-647
et al., 2013, Heterogeneous models place the root of the placental mammal phylogeny., Mol Biol Evol, Vol:30, Pages:2145-2156