Imperial College London
Alternate

Mr Colin D Bicknell BM MD FRCS

Faculty of Medicine, Department of Surgery & Cancer

Clinical Reader in Vascular Surgery
 
 
 
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Contact

 

+44 (0)20 3312 6428colin.bicknell

 
 
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Location

 

1020Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kirkilesis:2020:10.1002/14651858.CD013422.pub2,
author = {Kirkilesis, G and Kakkos, SK and Bicknell, C and Salim, S and Kakavia, K},
doi = {10.1002/14651858.CD013422.pub2},
journal = {Cochrane Database of Systematic Reviews},
pages = {CD013422--CD013422},
title = {Treatment of distal deep vein thrombosis.},
url = {http://dx.doi.org/10.1002/14651858.CD013422.pub2},
volume = {4},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The treatment of distal (below the knee) deep vein thrombosis (DVT) is not clearly established. Distal DVT can either be treated with anticoagulation, or monitored with close follow-up to detect progression to the proximal veins (above the knee), which requires anticoagulation. Proponents of this monitoring strategy base their decision to withhold anticoagulation on the fact that progression is rare and most people can be spared from potential bleeding and other adverse effects of anticoagulation. OBJECTIVES: To assess the effects of different treatment interventions for people with distal (below the knee) deep vein thrombosis (DVT). SEARCH METHODS: The Cochrane Vascular Information Specialist searched the Cochrane Vascular Specialised Register, CENTRAL, MEDLINE, Embase and CINAHL databases and World Health Organization International Clinical Trials Registry Platform and ClinicalTrials.gov trials registers to 12 February 2019. We also undertook reference checking to identify additional studies. SELECTION CRITERIA: Randomised controlled trials (RCTs) for the treatment of distal DVT. DATA COLLECTION AND ANALYSIS: Two review authors independently selected trials and extracted data. We resolved disagreements by discussion. Primary outcomes of interest were recurrence of venous thromboembolism (VTE), DVT and major bleeding and follow up ranged from three months to two years. We performed fixed-effect model meta-analyses with risk ratio (RRs) and 95% confidence intervals (CIs). We assessed the certainty of the evidence using GRADE. MAIN RESULTS: We identified eight RCTs reporting on 1239 participants. Five trials randomised participants to anticoagulation for up to three months versus no anticoagulation. Three trials compared anticoagulation treatment for different time periods. Anticoagulant compared to no intervention or placebo for distal DVT treatment Anticoagulation with a vitamin K antagonist (VKA) reduced the risk of recurrent VTE during follow-up compa
AU  - Kirkilesis,G
AU  - Kakkos,SK
AU  - Bicknell,C
AU  - Salim,S
AU  - Kakavia,K
DO  - 10.1002/14651858.CD013422.pub2
EP  - 013422
PY  - 2020///
SN  - 1469-493X
SP  - 013422
TI  - Treatment of distal deep vein thrombosis.
T2  - Cochrane Database of Systematic Reviews
UR  - http://dx.doi.org/10.1002/14651858.CD013422.pub2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32271939
UR  - https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013422.pub2/full
UR  - http://hdl.handle.net/10044/1/79238
VL  - 4
ER  -
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