Imperial College London
Alternate

DrDavidAanensen

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3896d.aanensen Website

 
 
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Location

 

G30Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Crellen:2016:10.1038/srep20954,
author = {Crellen, T and Allan, F and David, S and Durrant, C and Huckvale, T and Holroyd, N and Emery, AM and Rollinson, D and Aanensen, DM and Berriman, M and Webster, JP and Cotton, JA},
doi = {10.1038/srep20954},
journal = {Scientific Reports},
title = {Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection.},
url = {http://dx.doi.org/10.1038/srep20954},
volume = {6},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S. mansoni based on high-coverage resequencing data from 10 global isolates and an isolate of the closely-related Schistosoma rodhaini, which infects rodents. Using population genetic tests, we document genes under directional and balancing selection in S. mansoni that may facilitate adaptation to the human host. Coalescence modeling reveals the speciation of S. mansoni and S. rodhaini as 107.5-147.6KYA, a period which overlaps with the earliest archaeological evidence for fishing in Africa. Our results indicate that S. mansoni originated in East Africa and experienced a decline in effective population size 20-90KYA, before dispersing across the continent during the Holocene. In addition, we find strong evidence that S. mansoni migrated to the New World with the 16-19(th) Century Atlantic Slave Trade.
AU  - Crellen,T
AU  - Allan,F
AU  - David,S
AU  - Durrant,C
AU  - Huckvale,T
AU  - Holroyd,N
AU  - Emery,AM
AU  - Rollinson,D
AU  - Aanensen,DM
AU  - Berriman,M
AU  - Webster,JP
AU  - Cotton,JA
DO  - 10.1038/srep20954
PY  - 2016///
SN  - 2045-2322
TI  - Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection.
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/srep20954
UR  - http://hdl.handle.net/10044/1/29883
VL  - 6
ER  -
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