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@article{Didelot:2016:10.1128/mBio.00525-16,
author = {Didelot, X and Dordel, J and Whittles, LK and Collins, C and Bilek, N and Bishop, CJ and White, PJ and Aanensen, DM and Parkhill, J and Bentley, SD and Spratt, BG and Harris, SR},
doi = {10.1128/mBio.00525-16},
journal = {mBio},
title = {Genomic analysis and comparison of two gonorrhoea outbreaks},
url = {http://dx.doi.org/10.1128/mBio.00525-16},
volume = {7},
year = {2016}
}

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TY  - JOUR
AB  - Gonorrhea is a sexually transmitted disease causing growing concern, with a substantial increase in reported incidence over the past few years in the United Kingdom and rising levels of resistance to a wide range of antibiotics. Understanding its epidemiology is therefore of major biomedical importance, not only on a population scale but also at the level of direct transmission. However, the molecular typing techniques traditionally used for gonorrhea infections do not provide sufficient resolution to investigate such fine-scale patterns. Here we sequenced the genomes of 237 isolates from two local collections of isolates from Sheffield and London, each of which was resolved into a single type using traditional methods. The two data sets were selected to have different epidemiological properties: the Sheffield data were collected over 6 years from a predominantly heterosexual population, whereas the London data were gathered within half a year and strongly associated with men who have sex with men. Based on contact tracing information between individuals in Sheffield, we found that transmission is associated with a median time to most recent common ancestor of 3.4 months, with an upper bound of 8 months, which we used as a criterion to identify likely transmission links in both data sets. In London, we found that transmission happened predominantly between individuals of similar age, sexual orientation, and location and also with the same HIV serostatus, which may reflect serosorting and associated risk behaviors. Comparison of the two data sets suggests that the London epidemic involved about ten times more cases than the Sheffield outbreak.
AU  - Didelot,X
AU  - Dordel,J
AU  - Whittles,LK
AU  - Collins,C
AU  - Bilek,N
AU  - Bishop,CJ
AU  - White,PJ
AU  - Aanensen,DM
AU  - Parkhill,J
AU  - Bentley,SD
AU  - Spratt,BG
AU  - Harris,SR
DO  - 10.1128/mBio.00525-16
PY  - 2016///
SN  - 2150-7511
TI  - Genomic analysis and comparison of two gonorrhoea outbreaks
T2  - mBio
UR  - http://dx.doi.org/10.1128/mBio.00525-16
UR  - http://hdl.handle.net/10044/1/32779
VL  - 7
ER  -

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