Publications
272 results found
Reynolds CJ, Jones C, Blohmke CJ, et al., 2014, The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles, Immunology, Vol: 143, Pages: 438-446, ISSN: 0019-2805
Reynolds C, Chong D, Raynsford E, et al., 2014, Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile., BMC Biology, Vol: 12, ISSN: 1741-7007
Ascough S, Ingram RJ, Chu KK, et al., 2014, Anthrax Lethal Factor as an Immune Target in Humans and Transgenic Mice and the Impact of HLA Polymorphism on CD4<SUP>+</SUP> T Cell Immunity, PLOS PATHOGENS, Vol: 10, ISSN: 1553-7366
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- Citations: 15
Vernet G, Mary C, Altmann DM, et al., 2014, Surveillance for Antimicrobial Drug Resistance in Under-Resourced Countries, EMERGING INFECTIOUS DISEASES, Vol: 20, Pages: 434-441, ISSN: 1080-6040
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- Citations: 58
Rinchai D, Nithichanon A, Buddhisa S, et al., 2013, Large scale human T cell epitope mapping of <i>Burkholderia pseudomallei</i>, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 133-133, ISSN: 0019-2805
Till SJ, Raynsford EJ, Reynolds CJ, et al., 2013, Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation, Thorax, Vol: 69, Pages: 335-345, ISSN: 0040-6376
Ascough S, Ingram R, Abarra A, et al., 2013, Injectional anthrax infection due to heroin use induces strong immunological memory, J Infect
Lowther DE, Chong DL, Ascough S, et al., 2013, Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response, ACTA NEUROPATHOLOGICA, Vol: 126, Pages: 501-515, ISSN: 0001-6322
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- Citations: 32
Ingram RJ, Harris A, Ascough S, et al., 2013, Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 173, Pages: 84-91, ISSN: 0009-9104
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- Citations: 8
Greenwood B, 2013, Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt, VACCINE, Vol: 31, Pages: 1453-1457, ISSN: 0264-410X
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- Citations: 28
Boyton RJ, Reynolds CJ, Quigley KJ, et al., 2013, Immune mechanisms and the impact of the disrupted lung microbiome in chronic bacterial lung infection and bronchiectasis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 171, Pages: 117-123, ISSN: 0009-9104
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- Citations: 45
Nicholas R, Dahdaleh D, Altmann DM, et al., 2013, Tuberculosis in London: not unexpected reply, LANCET, Vol: 381, Pages: 201-202, ISSN: 0140-6736
Nicholas R, Dahdaleh D, Altmann DM, et al., 2013, Authors' reply, The Lancet, Vol: 381, Pages: 201-202, ISSN: 0140-6736
Durrenberger PF, Webb LV, Sim MJ, et al., 2012, Increased HLA-E expression in white matter lesions in multiple sclerosis., Immunology, Vol: 137, Pages: 317-325, ISSN: 0019-2805
AbstractThe molecular mechanisms underpinning central nervous system (CNS) damage in multiple sclerosis (MS) are complex and it is widely accepted that there is an autoimmune component. Both adaptive and innate immune effector mechanisms are believed to contribute to tissue disease aetiology. HLA-E is a non-classical MHC class Ib molecule that acts as the ligand for the NKG2A inhibitory receptor present on natural killer (NK) and CD8(+) cells. Peptide binding and stabilisation of HLA-E is often considered to signal infection or cell stress. Here we examine the up-regulation of HLA-E in MS brain tissue. Expression is significantly increased in white matter lesions in the brain of MS patients compared to white matter of neurologically healthy controls. Furthermore, using quantitative immunohistochemistry and confocal microscopy, we show increased HLA-E protein expression in endothelial cells of active MS lesions. Non-inflammatory chronic lesions express significantly less HLA-E protein, comparable to levels found in white matter from controls. Increased HLA-E protein levels were associated with higher scores of inflammation. These results suggest the potential for an effect in CNS pathogenesis from HLA-E modulation in stressed tissue. Co-localisation with infiltrating CD8(+) cells implicates a possible role for HLA-E restricted regulatory CD8(+) cells, as has been proposed in other autoimmune diseases.
Ascough S, Ingram RJ, Altmann DM, 2012, Anthrax Lethal Toxin and the Induction of CD4 T Cell Immunity, TOXINS, Vol: 4, Pages: 878-899
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- Citations: 8
Ascough S, Ingram RJ, Musson JA, et al., 2012, Identification of immunodominant T cell epitopes from anthrax protective antigen for inclusion in a rationally designed sub-unit based vaccine, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 761-761, ISSN: 0019-2805
Dahdaleh D, Altmann DM, Malik O, et al., 2012, Breathlessness, night sweats, and weight loss on natalizumab, LANCET, Vol: 380, Pages: 726-727, ISSN: 0140-6736
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- Citations: 17
Robertson BD, Altmann D, Barry C, et al., 2012, Detection and treatment of subclinical tuberculosis, Tuberculosis, Vol: 92, Pages: 447-452, ISSN: 1873-281X
Reduction of active disease by preventive therapy has the potential to make an important contribution towards the goal of tuberculosis (TB) elimination. This report summarises discussions amongst a Working Group convened to consider areas of research that will be important in optimising the design and delivery of preventative therapies. The Working Group met in Cape Town on 26th February 2012, following presentation of results from the GC11 Grand Challenges in Global Health project to discover drugs for latent TB.
Chong DLW, Ingram RJ, Lowther DE, et al., 2012, The nature of innate and adaptive interleukin-17A responses in sham or bacterial inoculation, IMMUNOLOGY, Vol: 136, Pages: 325-333, ISSN: 0019-2805
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- Citations: 10
Ascough S, Ingram RJ, Metan G, et al., 2012, Comment on "Frequency of Epitope-Specific Naive CD4<SUP>+</SUP> T Cells Correlates with Immunodominance in the Human Memory Repertoire", JOURNAL OF IMMUNOLOGY, Vol: 188, Pages: 5205-5206, ISSN: 0022-1767
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- Citations: 1
Altmann DM, Balloux F, Boyton RJ, 2012, Diverse approaches to analysing the history of human and pathogen evolution: how to tell the story of the past 70 000 years Introduction, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 367, Pages: 765-769, ISSN: 0962-8436
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- Citations: 4
Kaushansky N, Altmann DM, David CS, et al., 2012, DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP), JOURNAL OF NEUROINFLAMMATION, Vol: 9
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- Citations: 34
Durrenberger PF, Ettorre A, Kamel F, et al., 2012, Innate Immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1), Journal of Neuroinflammation, Vol: 9, ISSN: 1742-2094
Boyton RJ, Altmann DM, 2012, Immune regulation in idiopathic bronchiectasis, ADVANCES AGAINST ASPERGILLOSIS I, Vol: 1272, Pages: 68-72, ISSN: 0077-8923
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- Citations: 5
Ettorre A, Kamel FO, Durrenberger PF, et al., 2011, KIR expression as a biomarker of multiple sclerosis disease type, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 172-172, ISSN: 0019-2805
Wakerley BR, Harman FE, Altmann DM, et al., 2011, Charcot-Marie-Tooth disease associated with recurrent optic neuritis, JOURNAL OF CLINICAL NEUROSCIENCE, Vol: 18, Pages: 1422-1423, ISSN: 0967-5868
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- Citations: 6
Wakerley BR, Nicholas RS, Malik OR, et al., 2011, The Effects of Disease Activity and Interferon-beta on Telomere Length and Telomerase Activity in Multiple Sclerosis, 63rd AAN Annual Meeting, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A135-A135, ISSN: 0028-3878
Chu KK, Tippayawat P, Walker NJ, et al., 2011, CD4+ T-cell immunity to the Burkholderia pseudomallei ABC transporter LolC in melioidosis., Eur J Immunol, Vol: 41, Pages: 107-115
Burkholderia pseudomallei causes melioidosis, a disease with a wide range of possible outcomes, from seroconversion and dormancy to sepsis and death. This spectrum of host-pathogen interactions poses challenging questions about the heterogeneity in immunity to B. pseudomallei. Models show protection to be dependent on CD4(+) cells and IFN-γ, but little is known about specific target antigens. Having previously implicated the ABC transporter, LolC, in protective immunity, we here use epitope prediction, HLA-binding studies, HLA-transgenic models and studies of T cells from seropositive individuals to characterize HLA-restricted LolC responses. Immunized mice showed long-lasting memory to the protein, whereas predictive algorithms identified epitopes within LolC that subsequently demonstrated strong HLA class II binding. Immunization of HLA-DR transgenics with LolC stimulated T-cell responses to four of these epitopes. Furthermore, the responsiveness of HLA transgenics to LolC revealed a hierarchy supportive of HLA polymorphism-determined differential susceptibility. Seropositive human donors of diverse HLA class II types showed T-cell responses to LolC epitopes, which are conserved among Burkholderia species including Burkholderia cenocepacia, associated with life-threatening cepacia complex in cystic fibrosis patients and Burkholderia mallei, which causes glanders. These findings suggest a role for LolC epitopes in multiepitope vaccine design for melioidosis and related diseases.
Chu KK, Tippayawat P, Walker NJ, et al., 2011, CD4<SUP>+</SUP> T-cell immunity to the <i>Burkholderia pseudomallei</i> ABC transporter LolC in melioidosis, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 41, Pages: 107-115, ISSN: 0014-2980
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- Citations: 6
Harris AJ, Durrenberger P, Kamel F, et al., 2010, Investigating the role of natural killer cell subsets in multiple sclerosis, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 125-125, ISSN: 0019-2805
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