Publications
272 results found
Lowther DE, Ascough S, Ettorre A, et al., 2010, Mechanism of disease in a spontaneous, humanised multiple sclerosis model - the relative role of Th1, Th17 and Treg cells, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 39-40, ISSN: 0019-2805
Musson JA, Ingram R, Durand G, et al., 2010, Repertoire of HLA-DR1-Restricted CD4 T-Cell Responses to Capsular Caf1 Antigen of <i>Yersinia pestis</i> in Human Leukocyte Antigen Transgenic Mice, INFECTION AND IMMUNITY, Vol: 78, Pages: 4356-4362, ISSN: 0019-9567
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- Citations: 14
Baillie LW, Huwar TB, Moore S, et al., 2010, An anthrax subunit vaccine candidate based on protective regions of <i>Bacillus anthracis</i> protective antigen and lethal factor, VACCINE, Vol: 28, Pages: 6740-6748, ISSN: 0264-410X
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- Citations: 36
Kotturi MF, Botten J, Maybeno M, et al., 2010, Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage., Immunome Res, Vol: 6
BACKGROUND: Several arenaviruses cause severe hemorrhagic fever and aseptic meningitis in humans for which no licensed vaccines are available. A major obstacle for vaccine development is pathogen heterogeneity within the Arenaviridae family. Evidence in animal models and humans indicate that T cell and antibody-mediated immunity play important roles in controlling arenavirus infection and replication. Because CD4+ T cells are needed for optimal CD8+ T cell responses and to provide cognate help for B cells, knowledge of epitopes recognized by CD4+ T cells is critical to the development of an effective vaccine strategy against arenaviruses. Thus, the goal of the present study was to define and characterize CD4+ T cell responses from a broad repertoire of pathogenic arenaviruses (including lymphocytic choriomeningitis, Lassa, Guanarito, Junin, Machupo, Sabia, and Whitewater Arroyo viruses) and to provide determinants with the potential to be incorporated into a multivalent vaccine strategy. RESULTS: By inoculating HLA-DRB1*0101 transgenic mice with a panel of recombinant vaccinia viruses, each expressing a single arenavirus antigen, we identified 37 human HLA-DRB1*0101-restricted CD4+ T cell epitopes from the 7 antigenically distinct arenaviruses. We showed that the arenavirus-specific CD4+ T cell epitopes are capable of eliciting T cells with a propensity to provide help and protection through CD40L and polyfunctional cytokine expression. Importantly, we demonstrated that the set of identified CD4+ T cell epitopes provides broad, non-ethnically biased population coverage of all 7 arenavirus species targeted by our studies. CONCLUSIONS: The identification of CD4+ T cell epitopes, with promiscuous binding properties, derived from 7 different arenavirus species will aid in the development of a T cell-based vaccine strategy with the potential to target a broad range of ethnicities within the general population and to protect against both Old and New World arenavirus infec
Ingram RJ, Chu KK, Metan G, et al., 2010, An Epitope of <i>Bacillus anthracis</i> Protective Antigen That Is Cryptic in Rabbits May Be Immunodominant in Humans, INFECTION AND IMMUNITY, Vol: 78, Pages: 2353-2353, ISSN: 0019-9567
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- Citations: 10
Ingram RJ, Metan G, Maillere B, et al., 2010, Natural Exposure to Cutaneous Anthrax Gives Long-Lasting T Cell Immunity Encompassing Infection-Specific Epitopes, JOURNAL OF IMMUNOLOGY, Vol: 184, Pages: 3814-3821, ISSN: 0022-1767
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- Citations: 39
Reynolds C, Barkans J, Clark P, et al., 2009, Natural killer T cells in bronchial biopsies from human allergen challenge model of allergic asthma., J Allergy Clin Immunol, Vol: 124, Pages: 860-862
Zota V, Nemirovsky A, Baron R, et al., 2009, HLA-DR Alleles in Amyloid β-Peptide Autoimmunity: A Highly Immunogenic Role for the DRB1*1501 Allele, JOURNAL OF IMMUNOLOGY, Vol: 183, Pages: 3522-3530, ISSN: 0022-1767
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- Citations: 37
Campbell JD, Buckland KF, McMillan SJ, et al., 2009, Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 206, Pages: 1535-1547, ISSN: 0022-1007
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- Citations: 168
Call MJ, Xing X, Cuny GD, et al., 2009, In Vivo Enhancement of Peptide Display by MHC Class II Molecules with Small Molecule Catalysts of Peptide Exchange, JOURNAL OF IMMUNOLOGY, Vol: 182, Pages: 6342-6352, ISSN: 0022-1767
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- Citations: 28
Altmann DM, 2009, Review series on helminths, immune modulation and the hygiene hypothesis: Nematode coevolution with adaptive immunity, regulatory networks and the growth of inflammatory diseases, IMMUNOLOGY, Vol: 126, Pages: 1-2, ISSN: 0019-2805
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- Citations: 9
Ingram RJ, Isaacs JD, Kaur G, et al., 2009, A role of cellular prion protein in programming T-cell cytokine responses in disease., FASEB J, Vol: 23, Pages: 1672-1684
The cellular prion protein (PrP(C)) is widely expressed in neural and non-neural tissues, but its function is unknown. Elucidation of the part played by PrP(C) in adaptive immunity has been a particular conundrum: increased expression of cell surface PrP(C) has been documented during T-cell activation, yet the functional significance of this activation remains unclear, with conflicting data on the effects of Prnp gene knockout on various parameters of T-cell immunity. We show here that Prnp mRNA is highly inducible within 8-24 h of T-cell activation, with surface protein levels rising from 24 h. When measured in parallel with CD69 and CD25, PrP(C) is a late activation antigen. Consistent with its up-regulation being a late activation event, PrP deletion did not alter T-cell-antigen presenting cell conjugate formation. Most important, activated PrP(0/0) T cells demonstrated much reduced induction of several T helper (Th) 1, Th2, and Th17 cytokines, whereas others, such as TNF-alpha and IL-9, were unaffected. These changes were investigated in the context of an autoimmune model and a bacterial challenge model. In experimental autoimmune encephalomyelitis, PrP-knockout mice showed enhanced disease in the face of reduced IL-17 responses. In a streptococcal sepsis model, this constrained cytokine program was associated with poorer local control of infection, although with reduced bacteremia. The findings indicate that PrP(C) is a potentially important molecule influencing T-cell activation and effector function.
Ingram RJ, Chu K, Metan G, et al., 2008, T cell epitope mapping anthrax: the detection of CD<sub>4</sub> epitopes in lethal factor, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL, Pages: 144-144, ISSN: 0019-2805
Ingram RJ, Chong DLW, Turner CE, et al., 2008, The role of T cells in acute <i>Streptococcus pyogenes</i> infection, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 62-62, ISSN: 0019-2805
Chong DLW, Ingram RJ, Altmann DM, et al., 2008, The involvement of TLR2 in activation of Tregs during <i>Streptococcus pyogenes</i> acute infection, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 116-116, ISSN: 0019-2805
Isaacs JD, Garden OA, Kaur G, et al., 2008, The cellular prion protein is preferentially expressed by CD4<SUP>+</SUP> CD25<SUP>+</SUP> Foxp3<SUP>+</SUP> regulatory T cells, IMMUNOLOGY, Vol: 125, Pages: 313-319, ISSN: 0019-2805
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- Citations: 14
Boyton RJ, Smith J, Jones M, et al., 2008, Human leucocyte antigen class II association in idiopathic bronchiectasis, a disease of chronic lung infection, implicates a role for adaptive immunity, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 152, Pages: 95-101, ISSN: 0009-9104
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- Citations: 26
Sriskandan S, Altmann DM, 2008, The immunology of sepsis, JOURNAL OF PATHOLOGY, Vol: 214, Pages: 211-223, ISSN: 0022-3417
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- Citations: 187
Altmann DM, 2008, Regulation, FoxP3, suppression and immunity, IMMUNOLOGY, Vol: 123, Pages: 1-2, ISSN: 0019-2805
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- Citations: 1
Faulkner L, Altmann DM, Ellmerich S, et al., 2007, Sexual dimorphism in superantigen shock involves elevated TNF-α and TNF-α-induced hepatic apoptosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 176, Pages: 473-482, ISSN: 1073-449X
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- Citations: 21
Boyton RJ, Altmann DM, 2007, Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class I in disease, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 149, Pages: 1-8, ISSN: 0009-9104
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- Citations: 137
von Delwig A, Altmann DM, Charlton FG, et al., 2007, T cell responses to a non-glycosylated epitope predominate in type II collagen-immunised HLA-DRB1*0101 transgenic mice, ANNALS OF THE RHEUMATIC DISEASES, Vol: 66, Pages: 599-604, ISSN: 0003-4967
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- Citations: 12
Altmann D, 2007, Immunology - fast moving times for the field and the journal, IMMUNOLOGY, Vol: 120, Pages: 291-291, ISSN: 0019-2805
Reynolds C, Ozerovitch L, Wilson R, et al., 2007, Toll-like receptors 2 and 4 and innate immunity in neutrophilic asthma and idiopathic bronchiectasis, THORAX, Vol: 62, Pages: 279-279, ISSN: 0040-6376
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- Citations: 7
Llewelyn M, Sriskandan S, Terrazzini N, et al., 2007, The Vβ specific response to bacterial superantigens is determined by concentration and HLA class II, Annual Congress of the British-Society-of-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 77-77, ISSN: 0019-2805
Boyton RJ, Altmann DM, Wright A, et al., 2007, Pulmonary infection with <i>Cryptococcus neoformans</i> in the face of underlying sarcoidosis, RESPIRATION, Vol: 74, Pages: 462-466, ISSN: 0025-7931
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- Citations: 8
Brenchley JM, Price DA, Schacker TW, et al., 2006, Microbial translocation is a cause of systemic immune activation in chronic HIV infection, NATURE MEDICINE, Vol: 12, Pages: 1365-1371, ISSN: 1078-8956
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- Citations: 2619
Isaacs JD, Ingram RJ, Collinge J, et al., 2006, The human prion protein residue 129 polymorphism lies within a cluster of Epitopes for T cell recognition, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Vol: 65, Pages: 1059-1068, ISSN: 0022-3069
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- Citations: 4
Isaacs JD, Jackson GS, Altmann DM, 2006, The role of the cellular prion protein in the immune system, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 146, Pages: 1-8, ISSN: 0009-9104
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- Citations: 72
Llewelyn M, Sriskandan S, Terrazzini N, et al., 2006, The TCR Vβ signature of bacterial superantigens spreads with stimulus strength, INTERNATIONAL IMMUNOLOGY, Vol: 18, Pages: 1433-1441, ISSN: 0953-8178
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- Citations: 26
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