Imperial College London
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ProfessorDannyAltmann

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Immunology
 
 
 
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Contact

 

+44 (0)20 3313 8212d.altmann

 
 
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Location

 

5S5CHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Reynolds:2020:10.3389/fimmu.2020.00185,
author = {Reynolds, CJ and Watber, P and Santos, CNO and Ribeiro, DR and Alves, JC and Fonseca, ABL and Bispo, AJB and Porto, RLS and Bokea, K and de, Jesus AMR and de, Almeida RP and Boyton, RJ and Altmann, DM},
doi = {10.3389/fimmu.2020.00185},
journal = {Frontiers in Immunology},
title = {Strong CD4 T cell responses to Zika virus antigens in a cohort of Dengue virus immune mothers of congenital Zika virus syndrome infants},
url = {http://dx.doi.org/10.3389/fimmu.2020.00185},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: There is an urgent need to understand the complex relationship between cross-reactive anti-viral immunity, disease susceptibility, and severity in the face of differential exposure to related, circulating Flaviviruses. Co-exposure to Dengue virus and Zika virus in Brazil is a case in point. A devastating aspect of the 2015-2016 South American Zika outbreak was the dramatic increase in numbers of infants born with microcephaly to mothers exposed to Zika virus during pregnancy. It has been proposed that this is more likely to ensue from Zika infection in women lacking cross-protective Dengue immunity. In this case series we measure the prevalence of Dengue immunity in a cohort of mothers exposed to Zika virus during pregnancy in the 2015-2016 Zika outbreak that gave birth to an infant affected by microcephaly and explore their adaptive immunity to Zika virus. Results: Fifty women from Sergipe, Brazil who gave birth to infants with microcephaly following Zika virus exposure during the 2015-16 outbreak were tested for serological evidence of Dengue exposure and IFNγ ELISpot spot forming cell (SFC) response to Zika virus. The majority (46/50) demonstrated Dengue immunity. IFNγ ELISpot responses to Zika virus antigens showed the following hierarchy: Env>NS1>NS3>C protein. Twenty T cell epitopes from Zika virus Env were identified. Responses to Zika virus antigens Env and NS1 were polyfunctional with cells making IFNγ, TNFα, IL-4, IL-13, and IL-10. In contrast, responses to NS5 only produced the immune regulatory TGFβ1 cytokine. There were SFC responses against Zika virus Env (1-20) and variant peptide sequences from West Nile virus, Dengue virus 1-4 and Yellow Fever virus. Conclusion: Almost all the women in our study showed serological evidence of Dengue immunity, suggesting that microcephaly can occur in DENV immune mothers. T cell immunity to Zika virus showed a multifunctional response to the antigens Env and NS1 and i
AU  - Reynolds,CJ
AU  - Watber,P
AU  - Santos,CNO
AU  - Ribeiro,DR
AU  - Alves,JC
AU  - Fonseca,ABL
AU  - Bispo,AJB
AU  - Porto,RLS
AU  - Bokea,K
AU  - de,Jesus AMR
AU  - de,Almeida RP
AU  - Boyton,RJ
AU  - Altmann,DM
DO  - 10.3389/fimmu.2020.00185
PY  - 2020///
SN  - 1664-3224
TI  - Strong CD4 T cell responses to Zika virus antigens in a cohort of Dengue virus immune mothers of congenital Zika virus syndrome infants
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2020.00185
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32132999
UR  - http://hdl.handle.net/10044/1/77315
VL  - 11
ER  -
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