Imperial College London
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ProfessorDannyAltmann

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Immunology
 
 
 
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Contact

 

+44 (0)20 3313 8212d.altmann

 
 
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Location

 

5S5CHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Reynolds:2018:10.1038/s41598-017-18781-1,
author = {Reynolds, CJ and Suleyman, OM and Ortega-Prieto, AM and Skelton, JK and Bonnesoeur, P and Blohm, A and Carregaro, V and Silva, JS and James, EA and Maillere, B and Dorner, M and Boyton, RJ and Altmann, DM},
doi = {10.1038/s41598-017-18781-1},
journal = {Scientific Reports},
title = {T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses},
url = {http://dx.doi.org/10.1038/s41598-017-18781-1},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Zika virus (ZIKV) Infection has several outcomes from asymptomatic exposure to rash, conjunctivitis, Guillain-Barré syndrome or congenital Zika syndrome. Analysis of ZIKV immunity is confounded by the fact that several related Flaviviruses infect humans, including Dengue virus 1–4, West Nile virus and Yellow Fever virus. HLA class II restricted T cell cross-reactivity between ZIKV and other Flaviviruses infection(s) or vaccination may contribute to protection or to enhanced immunopathology. We mapped immunodominant, HLA class II restricted, CD4 epitopes from ZIKV Envelope (Env), and Non-structural (NS) NS1, NS3 and NS5 antigens in HLA class II transgenic mice. In several cases, ZIKV primed CD4 cells responded to homologous sequences from other viruses, including DENV1–4, WNV or YFV. However, cross-reactive responses could confer immune deviation - the response to the Env DENV4 p1 epitope in HLA-DR1 resulted in IL-17A immunity, often associated with exacerbated immunopathogenesis. This conservation of recognition across Flaviviruses, may encompass protective and/or pathogenic components and poses challenges to characterization of ZIKV protective immunity.
AU  - Reynolds,CJ
AU  - Suleyman,OM
AU  - Ortega-Prieto,AM
AU  - Skelton,JK
AU  - Bonnesoeur,P
AU  - Blohm,A
AU  - Carregaro,V
AU  - Silva,JS
AU  - James,EA
AU  - Maillere,B
AU  - Dorner,M
AU  - Boyton,RJ
AU  - Altmann,DM
DO  - 10.1038/s41598-017-18781-1
PY  - 2018///
SN  - 2045-2322
TI  - T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-017-18781-1
UR  - http://hdl.handle.net/10044/1/55342
VL  - 8
ER  -
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