I am a clinical senior lecturer in respiratory fungal diseases at the National Heart and Lung Institute, Imperial College London and honorary consultant physician in infectious diseases and medical mycology to the Royal Brompton and Harefield NHS Trust. My research is primarily on innate immunity to Aspergillus fumigatus with a particular focus on macrophage cell biology and signal transduction. In addition I am involved in clinical translation relevant to medical mycology.
I initially studied Trypanosomal peroxidases with John Kelly and David Horn at the London School of Hygiene and Tropical Medicine during my MSc in pathogen Molecular Biology. I went on to undertake my PhD with Ken Haynes and Tom Rogers at Imperial on fungal host adaptation. I was subsequently awarded a MRC Clinician Scientist Fellowship to retrain in immunology and established the fungal immunobiology laboratory at Imperial. I have recently moved to the NHLI to further support the development of academic medical mycology and clinical infectious diseases at the NHLI and Royal Brompton and Harefield.
et al., Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris, Emerging Microbes and Infections, ISSN:2222-1751
et al., 2017, Immunotherapy for infectious diseases in haematological immunocompromise., Br J Haematol, Vol:177, Pages:348-356
et al., 2017, Caspofungin Increases Fungal Chitin and Eosinophil and γδ T Cell-Dependent Pathology in Invasive Aspergillosis., J Immunol, Vol:199, Pages:624-632
et al., 2017, A subset of virus-specific CD161+ T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in AML., Blood, Vol:129, Pages:740-758
et al., 2018, Reduced Clearance of Fungal Spores by Chronic Obstructive Pulmonary Disease GM-CSF- and M-CSF-derived Macrophages, American Journal of Respiratory Cell and Molecular Biology, Vol:58, ISSN:1044-1549, Pages:271-273