I am a clinical senior lecturer in respiratory fungal diseases at the National Heart and Lung Institute, Imperial College London and honorary consultant physician in infectious diseases and medical mycology to the Royal Brompton and Harefield NHS Trust. My research is primarily on innate immunity to Aspergillus fumigatus with a particular focus on macrophage cell biology and signal transduction. In the laboratory we are increasingly studying how Aspergillus interacts with other opportunistic bacterial pathogens in the lung during co-infection. I also have a strong interest in fungal genomics, mainly through collaboration with Matt Fisher in the School of Public Health, which is underpinned by clinical responsibility for medical mycology at the Royal Brompton and Harefield NHS Trust. .
I initially studied Trypanosomal peroxidases with John Kelly and David Horn at the London School of Hygiene and Tropical Medicine during my MSc in pathogen Molecular Biology. I went on to undertake my PhD with Ken Haynes and Tom Rogers at Imperial on fungal host adaptation. I was subsequently awarded a MRC Clinician Scientist Fellowship to retrain in immunology and established the fungal immunobiology laboratory in the Department of Medicine at Imperial in 2010.
In 2014 I moved to the NHLI to further support the development of academic medical mycology and clinical infectious diseases at the NHLI and Royal Brompton and Harefield. Within the Respiratory Infection team at the Royal Brompton Hospital we have established significant cohorts of lung transplant and chronic respiratory disease patients with chronic respiratory fungal disease, usually in the context of bacterial and mycobacterial co-infection. Clinical observations in these cohorts are increasingly driving my research program at Imperial.
et al., 2018, High prevalence of triazole resistance in clinical Aspergillus fumigatus isolates in a specialist cardiothoracic centre, International Journal of Antimicrobial Agents, Vol:52, ISSN:0924-8579, Pages:637-642
et al., 2018, Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis., Blood, Vol:132, Pages:1985-1988
et al., 2018, Human NK Cells Develop an Exhaustion Phenotype During Polar Degranulation at the Aspergillus fumigatus Hyphal Synapse, Frontiers in Immunology, Vol:9, ISSN:1664-3224
et al., 2018, A Prospective Real-World Study of the Impact of an Antifungal Stewardship Program in a Tertiary Respiratory-Medicine Setting, Antimicrobial Agents and Chemotherapy, Vol:62, ISSN:0066-4804
et al., 2018, Surveillance for Azole-Resistant Aspergillus fumigatus in a Centralized Diagnostic Mycology Service, London, United Kingdom, 1998-2017, Frontiers in Microbiology, Vol:9, ISSN:1664-302X