I am a clinical senior lecturer in respiratory fungal diseases at the National Heart and Lung Institute, Imperial College London and honorary consultant physician in infectious diseases and medical mycology to the Royal Brompton and Harefield NHS Trust. My research is primarily on innate immunity to Aspergillus fumigatus with a particular focus on macrophage cell biology and signal transduction. In addition I am involved in clinical translation relevant to medical mycology.
I initially studied Trypanosomal peroxidases with John Kelly and David Horn at the London School of Hygiene and Tropical Medicine during my MSc in pathogen Molecular Biology. I went on to undertake my PhD with Ken Haynes and Tom Rogers at Imperial on fungal host adaptation. I was subsequently awarded a MRC Clinician Scientist Fellowship to retrain in immunology and established the fungal immunobiology laboratory at Imperial. I have recently moved to the NHLI to further support the development of academic medical mycology and clinical infectious diseases at the NHLI and Royal Brompton and Harefield.
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et al., 2018, Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis., Blood
et al., 2018, Impact of an antifungal stewardship programme in a tertiary respiratory medicine setting: A prospective real-world study., Antimicrob Agents Chemother
et al., 2018, Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris (vol 7, pg 43, 2018), Emerging Microbes & Infections, Vol:7, ISSN:2222-1751
et al., 2018, In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection, Antimicrobial Agents and Chemotherapy, Vol:62, ISSN:0066-4804