I am a Reader in Infectious Diseases and Medical Mycology in the Department of Microbiology, Imperial College London and honorary consultant physician in infectious diseases and medical mycology to the Royal Brompton and Harefield NHS Trust and Imperial College Healthcare. My research is primarily on innate immunity to Aspergillus fumigatus with a particular focus on macrophage cell biology and signal transduction. In the laboratory we are increasingly studying how Aspergillus interacts with other opportunistic bacterial pathogens in the lung during co-infection, in particular Mycobacterium tuberculosis and Pseudomonas aeruginosa. I also have a strong interest in fungal genomics, mainly through collaboration with Matt Fisher in the School of Public Health, which is underpinned by clinical responsibility for medical mycology at the Royal Brompton and Harefield NHS Trust. .
I initially studied Trypanosomal peroxidases with John Kelly and David Horn at the London School of Hygiene and Tropical Medicine during my MSc in pathogen Molecular Biology. I went on to undertake my PhD with Ken Haynes, Tom Rogers and Elaine Bignell at Imperial on fungal host adaptation. I was subsequently awarded a MRC Clinician Scientist Fellowship to retrain in immunology and established the fungal immunobiology laboratory in the Department of Medicine at Imperial in 2010.
In 2014 I moved to the NHLI to further support the development of academic medical mycology and clinical infectious diseases at the NHLI and Royal Brompton and Harefield. Within the Respiratory Infection team at the Royal Brompton Hospital we have established significant cohorts of lung transplant and chronic respiratory disease patients with chronic respiratory fungal disease, usually in the context of bacterial and mycobacterial co-infection. Clinical observations in these cohorts are increasingly driving my research program at Imperial.
In 2019 I rejoined the Department of Microbiology in the newly formed Department of Infectious Diseases at Imperial and now also provide Infectious Diseases and Medical Mycology clinical support to Imperial College Healthcare.
Williams TJ, Harvey S, Armstrong-James D, 2020, Immunotherapeutic approaches for fungal infections, Current Opinion in Microbiology, Vol:58, ISSN:1369-5274, Pages:130-137
Pagani N, Armstrong-James D, Reed A, 2020, Successful salvage therapy for fungal bronchial anastomotic infection after -lung transplantation with an inhaled triazole anti-fungal PC945., J Heart Lung Transplant, Vol:39, Pages:1505-1506
et al., 2020, Comparative Evaluation of MIRONAUT-AM and CLSI broth microdilution method for antifungal susceptibility testing of Aspergillus species against four commonly used antifungals, Medical Mycology, Vol:58, ISSN:1369-3786, Pages:1085-1090
et al., 2020, Confronting and mitigating the risk of COVID-19 Associated Pulmonary Aspergillosis (CAPA), European Respiratory Journal, Vol:56, ISSN:0903-1936, Pages:1-10
et al., 2020, Optimal management of acute kidney injury in critically ill patients with invasive fungal infections being treated with liposomal amphotericin B., Bmj Case Rep, Vol:13