Imperial College London
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ProfessorDariusArmstrong-James

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases and Medical Mycology
 
 
 
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Contact

 

d.armstrong

 
 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schelenz:2016:10.1186/s13756-016-0132-5,
author = {Schelenz, S and Hagen, F and Rhodes, JL and Abdolrasouli, A and Chowdhary, A and Hall, A and Ryan, L and Shackleton, J and Trimlett, R and Meis, JF and Armstrong-James, DPH and Fisher, MC},
doi = {10.1186/s13756-016-0132-5},
journal = {Antimicrobial Resistance and Infection Control},
title = {First hospital outbreak of the globally emerging Candida auris in a European hospital},
url = {http://dx.doi.org/10.1186/s13756-016-0132-5},
volume = {5},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Candida auris is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission.We report an ongoing outbreak of C. auris in a London cardio-thoracic center between April 2015 and July 2016. This isthe first report of C. auris in Europe and the largest outbreak so far. We describe the identification, investigation andimplementation of control measures.Methods: Data on C. auris case demographics, environmental screening, implementation of infection prevention/controlmeasures, and antifungal susceptibility of patient isolates were prospectively recorded then analysed retrospectively.Speciation of C. auris was performed by MALDI-TOF and typing of outbreak isolates performed by amplified fragmentlength polymorphism (AFLP).Results: This report describes an ongoing outbreak of 50 C. auris cases over the first 16 month (April 2015 to July 2016)within a single Hospital Trust in London. A total of 44 % (n = 22/50) patients developed possible or proven C. aurisinfection with a candidaemia rate of 18 % (n = 9/50). Environmental sampling showed persistent presence of the yeastaround bed space areas. Implementation of strict infection and prevention control measures included: isolationof cases and their contacts, wearing of personal protective clothing by health care workers, screening ofpatients on affected wards, skin decontamination with chlorhexidine, environmental cleaning with chorinebased reagents and hydrogen peroxide vapour. Genotyping with AFLP demonstrated that C. auris isolates fromthe same geographic region clustered.Conclusion: This ongoing outbreak with genotypically closely related C. auris highlights the importance ofappropriate species identification and rapid detection of cases in order to contain hospital acquired transmission.
AU  - Schelenz,S
AU  - Hagen,F
AU  - Rhodes,JL
AU  - Abdolrasouli,A
AU  - Chowdhary,A
AU  - Hall,A
AU  - Ryan,L
AU  - Shackleton,J
AU  - Trimlett,R
AU  - Meis,JF
AU  - Armstrong-James,DPH
AU  - Fisher,MC
DO  - 10.1186/s13756-016-0132-5
PY  - 2016///
SN  - 2047-2994
TI  - First hospital outbreak of the globally emerging Candida auris in a European hospital
T2  - Antimicrobial Resistance and Infection Control
UR  - http://dx.doi.org/10.1186/s13756-016-0132-5
UR  - http://hdl.handle.net/10044/1/39948
VL  - 5
ER  -
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