Imperial College London
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ProfessorDariusArmstrong-James

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases and Medical Mycology
 
 
 
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Contact

 

d.armstrong

 
 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bercusson:2016:mmy/myw072,
author = {Bercusson, A and de, Boer L and Armstrong-James, D},
doi = {mmy/myw072},
journal = {Medical Mycology},
title = {Endosomal sensing of fungi: current understanding and emerging concepts},
url = {http://dx.doi.org/10.1093/mmy/myw072},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Endosomal sensing represents a key strategy by which mammalian cells detect parasitization by invading pathogens. This is critical for the control of fungal pathogens, which are for the most part phagocytosed by effector cells of the innate immune system. Despite rapid overall progress in our understanding of endosomal responses in recent times, relatively little is known about how the endosomal sensing system detects fungi and the ensuing immunological consequences. Considering that many fungal pathogens must overcome and evade endosomal killing in order to survive in the host, understanding this key area of the early innate response is crucial for our understanding of fungal infection. In this review we present a summary of our current knowledge of endosomal sensing within the context of fungal pathogens, with a focus on the myeloid compartment.
AU  - Bercusson,A
AU  - de,Boer L
AU  - Armstrong-James,D
DO  - mmy/myw072
PY  - 2016///
SN  - 1460-2709
TI  - Endosomal sensing of fungi: current understanding and emerging concepts
T2  - Medical Mycology
UR  - http://dx.doi.org/10.1093/mmy/myw072
ER  -
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