Imperial College London

Dr Danielle Belgrave

Faculty of MedicineDepartment of Medicine

Research Fellow in Biomedical Modelling
 
 
 
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Contact

 

+44 (0)20 7594 3633d.belgrave CV

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

My research focuses on integrating expert scientific knowledge to develop statistical machine learning models to understand disease progression over time. The aim is to develop probabilistic models in the context of asthma and allergic disease with approaches which are generalizable to identifying distinct subtypes (endotypes) of disease evolution and understanding the underlying mechanisms of these subtypes. I'm particularly interested in machine learning to identify personalized disease management strategies through understanding the underlying latent manifestations of disease and their distinct genetic and environmental characteristics. I received an MRC Career Development Award in Biostatistics (2015 – 2018) with the project “Unified probabilistic latent variable modelling strategies to accelerate endotype discovery in longitudinal studies”. 

I was awarded a Microsoft PhD Scholarship and did my PhD at The University of Manchester (2010 – 2013) with Prof Iain Buchan, Prof Christopher Bishop (Microsoft Research Cambridge) and Prof Adnan Custovic. My thesis focused on the development and application of Bayesian machine learning models to understand the aetiology of asthma and allergic disease. Prior to that,I received an MSc in Statistics at University College London and a BSc in Business Mathematics and Statistics at The London School of Economics. Prior to joining Imperial, I worked as a Statistician at GlaxoSmithKline.

I am a collaborator on the Study Team for Early Life Asthma Research (STELAR), a consortium of birth cohorts across the UK. The aims of this project are to develop a web-based Asthma e-Lab which combines rich phenotypic data across these birth cohorts and to develop innovative computational statistical methods to identify novel endotypes of childhood asthma, enabling investigation of and discovery of endotype-specific pathophysiological mechanism.

Selected Publications

Journal Articles

Belgrave D, Henderson J, Simpson A, et al., 2016, Disaggregating asthma: big Investigation vs. big data, Journal of Allergy and Clinical Immunology, Vol:139, ISSN:1097-6825, Pages:400-407

Holt PG, Strickland D, Bosco A, et al., 2016, Distinguishing benign from pathologic T(H)2 immunity in atopic children, Journal of Allergy and Clinical Immunology, Vol:137, ISSN:0091-6749, Pages:379-387

Mohammad HR, Belgrave D, Harding KK, et al., 2016, Age, sex and the association between skin test responses and IgE titres with asthma, Pediatric Allergy and Immunology, Vol:27, ISSN:0905-6157, Pages:313-319

Belgrave DCM, Buchan L, Bishop C, et al., 2014, Trajectories of Lung Function during Childhood, American Journal of Respiratory and Critical Care Medicine, Vol:189, ISSN:1073-449X, Pages:1101-1109

Belgrave DCM, Simpson A, Semic-Jusufagic A, et al., 2013, Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing, Journal of Allergy and Clinical Immunology, Vol:132, ISSN:0091-6749, Pages:575-+

Bonnelykke K, Sleiman P, Nielsen K, et al., 2014, A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations, Nature Genetics, Vol:46, ISSN:1061-4036, Pages:51-+

Ic-Jusufagic AS, Belgrave D, Pickles A, et al., 2014, Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study, Lancet Respiratory Medicine, Vol:2, ISSN:2213-2600, Pages:621-630

Belgrave DCM, Granell R, Simpson A, et al., 2014, Developmental Profiles of Eczema, Wheeze, and Rhinitis: Two Population-Based Birth Cohort Studies, Plos Medicine, Vol:11, ISSN:1549-1676, Pages:e1001748-e1001748

Simpson A, Lazic N, Belgrave DCM, et al., 2015, Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years, Journal of Allergy and Clinical Immunology, Vol:136, ISSN:0091-6749, Pages:1224-1231

Custovic A, Sonntag H-J, Buchan IE, et al., 2015, Evolution pathways of IgE responses to grass and mite allergens throughout childhood, Journal of Allergy and Clinical Immunology, Vol:136, ISSN:0091-6749, Pages:1645-U327

Guerra S, Halonen M, Vasquez MM, et al., 2015, Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study, Lancet Respiratory Medicine, Vol:3, ISSN:2213-2600, Pages:613-620

Belgrave DC, Simpson A, Buchan IE, et al., 2015, Atopic dermatitis and respiratory allergy: what is the link, Current Dermatology Reports, Vol:4, ISSN:2162-4933, Pages:221-227

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