Doryen Bubeck received her PhD in Biophysics from Harvard University in 2005 where she used cryo-electron micrsocopy to investigate the cell entry mechanism of poliovirus. As an EMBO postdoctoral fellow and Cancer Research Institute Fellow at the University of Oxford, she continued to explore the structures of membrane proteins, focusing on the complement immune pathway. A recent highlight (Hadders & Bubeck et al., Cell Rep. 2012) is the discovery that complement components associate through a sideways alignment of their central MAC-perforin domains (MACPF). These results provide a structural framework for understanding the complex protein associations underlying activation of this innate immune effector. Doryen Bubeck is a lecturer in Structural Biology within the Department of Life Sciences and recipient of a Cancer Research UK Career Establishment Award. Her current research adopts an integrated structural approach merging cryo-electron microscopy and Xray crystallography to investigate the role of membrane proteins in host-pathogen interactions. She aims to investigate how membrane attack complex (MAC) pore formation is controlled, a process important for fighting infections and preventing complement-mediated tissue damage.
Bayly-Jones C, Bubeck D, Dunstone MA, 2017, The mystery behind membrane insertion: a review of the complement membrane attack complex, Philosophical Transactions of the Royal Society B-biological Sciences, Vol:372, ISSN:0962-8436
Morgan BP, Boyd C, Bubeck D, 2017, Molecular cell biology of complement membrane attack., Semin Cell Dev Biol
et al., 2016, Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation, Scientific Reports, Vol:6, ISSN:2045-2322
et al., 2017, Unravelling the Mechanism of Membrane Attack Complex Pore Closure, 58th Annual Meeting of the Biophysical-Society, CELL PRESS, Pages:335A-335A, ISSN:0006-3495
Morgan BP, Serna M, Bubeck D, 2016, Complex beauty complements membrane attack, ELSEVIER GMBH, URBAN & FISCHER VERLAG, Pages:1194-1194, ISSN:0171-2985