Doryen Bubeck received her PhD in Biophysics from Harvard University in 2005 where she used cryo-electron microscopy (cryo-EM) to investigate the cell entry mechanism of poliovirus. As an EMBO postdoctoral fellow and Cancer Research Institute Fellow at the University of Oxford, she continued to explore the structures of membrane proteins, focusing on the complement immune pathway. Over 50 years since the complement membrane attack complex was visualized, a recent highlight from the lab reports the first 3D structure of the complete pore. These results provide a framework for understanding the complex protein associations underlying activation of this innate immune effector and opens new directions of research investigating the lipid environment’s impact on MAC function. Doryen Bubeck is a senior lecturer in Structural Biology within the Department of Life Sciences and recipient of a Cancer Research UK Career Establishment Award. Her current research adopts a structural to investigate the role of membrane proteins in host-pathogen interactions. She aims to investigate how membrane attack complex (MAC) pore formation is controlled, a process important for fighting infections and preventing complement-mediated tissue damage.
Bayly-Jones C, Bubeck D, Dunstone MA, 2017, The mystery behind membrane insertion: a review of the complement membrane attack complex, Philosophical Transactions of the Royal Society B-biological Sciences, Vol:372, ISSN:0962-8436
Morgan BP, Boyd C, Bubeck D, 2017, Molecular cell biology of complement membrane attack, Seminars in Cell & Developmental Biology, Vol:72, ISSN:1084-9521, Pages:124-132
et al., 2016, Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones, Scientific Reports, Vol:6, ISSN:2045-2322
et al., 2016, Structural basis of complement membrane attack complex formation, Nature Communications, Vol:7, ISSN:2041-1723
et al., 2017, Unravelling the Mechanism of Membrane Attack Complex Pore Closure, 58th Annual Meeting of the Biophysical-Society, CELL PRESS, Pages:335A-335A, ISSN:0006-3495