Imperial College London
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ProfessorDenisDoorly

Faculty of Engineering, Department of Aeronautics

Professor of Fluid Mechanics
 
 
 
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Contact

 

d.doorly

 
 
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Location

 

313ACity and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Doorly:2021:10.1038/s41598-021-93769-6,
author = {Doorly, D and Xiao, Q and Bates, A and Cetto, R},
doi = {10.1038/s41598-021-93769-6},
journal = {Nature Scientific Reports},
pages = {1--13},
title = {The effect of decongestion on nasal airway patency and airflow},
url = {http://dx.doi.org/10.1038/s41598-021-93769-6},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Nasal decongestant reduces blood flow to the nasal turbinates, reducing tissue volume and increasing nasal airway patency. This study maps the changes in nasal anatomy and measures how these changes affect nasal resistance, flow partitioning between superior and inferior cavity, flow patterns and wall shear stress. High-resolution MRI was applied to capture nasal anatomy in 10 healthy subjects before and after application of a topical decongestant. Computational fluid dynamics simulated nasal airflow at steady inspiratory flow rates of 15 L.min−1 and 30 L.min−1. The results show decongestion mainly increases the cross-sectional area in the turbinate region and SAVR is reduced (median approximately 40% reduction) in middle and lower parts of the cavity. Decongestion reduces nasal resistance by 50% on average, while in the posterior cavity, nasal resistance decreases by a median factor of approximately 3 after decongestion. We also find decongestant regularises nasal airflow and alters the partitioning of flow, significantly decreasing flow through the superior portions of the nasal cavity. By comparing nasal anatomies and airflow in their normal state with that when pharmacologically decongested, this study provides data for a broad range of anatomy and airflow conditions, which may help characterize the extent of nasal variability.
AU  - Doorly,D
AU  - Xiao,Q
AU  - Bates,A
AU  - Cetto,R
DO  - 10.1038/s41598-021-93769-6
EP  - 13
PY  - 2021///
SN  - 2045-2322
SP  - 1
TI  - The effect of decongestion on nasal airway patency and airflow
T2  - Nature Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-93769-6
UR  - https://www.nature.com/articles/s41598-021-93769-6
UR  - http://hdl.handle.net/10044/1/90717
VL  - 11
ER  -
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