Imperial College London
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ProfessorDarioFarina

Faculty of Engineering, Department of Bioengineering

Chair in Neurorehabilitation Engineering
 
 
 
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Contact

 

+44 (0)20 7594 1387d.farina Website

 
 
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Location

 

RSM 4.15Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ibáñez:2021:10.1152/japplphysiol.00293.2021,
author = {Ibáñez, J and Angeli, CA and Harkema, SJ and Farina, D and Rejc, E},
doi = {10.1152/japplphysiol.00293.2021},
journal = {Journal of Applied Physiology},
pages = {1100--1110},
title = {Recruitment order of motor neurons promoted by epidural stimulation in individuals with spinal cord injury.},
url = {http://dx.doi.org/10.1152/japplphysiol.00293.2021},
volume = {131},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Spinal cord epidural stimulation (scES) combined with activity-based training can promote motor function recovery in individuals with motor complete spinal cord injury (SCI). The characteristics of motor neuron recruitment, which influence different aspects of motor control, are still unknown when motor function is promoted by scES. Here, we enrolled five individuals with chronic motor complete SCI implanted with an scES unit to study the recruitment order of motor neurons during standing enabled by scES. We recorded high-density electromyography (HD-EMG) signals on the vastus lateralis muscle and inferred the order of recruitment of motor neurons from the relation between amplitude and conduction velocity of the scES-evoked EMG responses along the muscle fibers. Conduction velocity of scES-evoked responses was modulated over time, whereas stimulation parameters and standing condition remained constant, with average values ranging between 3.0 ± 0.1 and 4.4 ± 0.3 m/s. We found that the human spinal circuitry receiving epidural stimulation can promote both orderly (according to motor neuron size) and inverse trends of motor neuron recruitment, and that the engagement of spinal networks promoting rhythmic activity may favor orderly recruitment trends. Conversely, the different recruitment trends did not appear to be related with time since injury or scES implant, nor to the ability to achieve independent knees extension, nor to the conduction velocity values. The proposed approach can be implemented to investigate the effects of stimulation parameters and training-induced neural plasticity on the characteristics of motor neuron recruitment order, contributing to improve mechanistic understanding and effectiveness of epidural stimulation-promoted motor recovery after SCI.NEW & NOTEWORTHY After motor complete spinal cord injury, the human spinal cord receiving epidural stimulation can promote both orderly and inverse trends o
AU  - Ibáñez,J
AU  - Angeli,CA
AU  - Harkema,SJ
AU  - Farina,D
AU  - Rejc,E
DO  - 10.1152/japplphysiol.00293.2021
EP  - 1110
PY  - 2021///
SN  - 1522-1601
SP  - 1100
TI  - Recruitment order of motor neurons promoted by epidural stimulation in individuals with spinal cord injury.
T2  - Journal of Applied Physiology
UR  - http://dx.doi.org/10.1152/japplphysiol.00293.2021
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34382840
UR  - https://journals.physiology.org/doi/full/10.1152/japplphysiol.00293.2021
UR  - http://hdl.handle.net/10044/1/93597
VL  - 131
ER  -
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