Imperial College London

ProfessorDarrelFrancis

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3381d.francis Website

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

579 results found

Asaria P, Francis DP, 2011, Heart Forecast for cardiovascular risk assessment, HEART, Vol: 97, Pages: 173-174, ISSN: 1355-6037

Journal article

Whinnett ZI, Nott G, Davies JER, Willson K, Manisty CH, Kanagaratnam P, Peters NS, Davies DW, Hughes AD, Mayet J, Francis DPet al., 2011, Maximizing Efficiency of Alternation Algorithms for Hemodynamic Optimization of the AV Delay of Cardiac Resynchronization Therapy, PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 34, Pages: 217-225, ISSN: 0147-8389

Journal article

Cole G, Francis DP, 2011, Comparable or STAR-heartlingly different left ventricular ejection fraction at baseline?, Eur J Heart Fail, Vol: 13

Journal article

Pabari PA, Kyriacou A, Whinnett ZI, Wright I, Willson K, Mayet J, Hughes AD, Francis DPet al., 2011, Invasive evaluation of whether decline in pressure after initial immediate increment on improving AV delay of CRT is due to vasodilatation or decline in cardiac function, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 183, Pages: 782-782, ISSN: 1073-449X

Journal article

Savage HO, Gerber RT, Tang K, Sachdev B, Cole G, Watson G, Petterson T, Assomoli R, Noor B, Sharp A, Ali A, Khamis R, Francis Det al., 2011, Reproducibility of the syntax score (synergy between percutaneous coronary intervention with taxus and cardiac surgery) in a real world setting: implications for the choice of contemporary revascularisation strategy, Circulation, ISSN: 0009-7322

Journal article

Baruah R, Giannoni A, Willson K, Manisty CH, Fontana M, Mebrate Y, Yadav H, Unsworth B, Kyriacou A, Sen S, Sutton R, Kanagaratnam P, Hughes AD, Mayet J, Francis DPet al., 2010, Timely Modulation of Cardiac Output by a Pacemaker Can Stabilize Induced Periodic Breathing, CIRCULATION, Vol: 122, ISSN: 0009-7322

Journal article

Giannoni A, Baruah R, Willson K, Mebrate Y, Mayet J, Emdin M, Hughes AD, Manisty CH, Francis DPet al., 2010, Real-Time Dynamic Carbon Dioxide Administration A Novel Treatment Strategy for Stabilization of Periodic Breathing With Potential Application to Central Sleep Apnea, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 56, Pages: 1832-1837, ISSN: 0735-1097

Journal article

Barron AJ, Medlow KI, Giannoni A, Unsworth B, Coats AJS, Mayet J, Howard LS, Francis DPet al., 2010, Reduced confounding by impaired ventilatory function with oxygen uptake efficiency slope and VE/VCO2 slope rather than peak oxygen consumption to assess exercise physiology in suspected heart failure., Congest Heart Fail, Vol: 16, Pages: 259-264

Heart failure and ventilatory disease often coexist; both create abnormalities in cardiopulmonary exercise test measurements. The authors evaluated the relative dependency of a well-recognized index of heart failure, peak oxygen consumption (VO(2)), and 2 newer indices, the minute ventilation (VE)/carbon dioxide production (VCO(2)) slope and oxygen uptake efficiency slope (OUES), on standard markers of impaired cardiac and ventilatory function. One hundred twenty-four patients (median age, 65.8; range, 22.6-84.9), with functional limitation from clinical heart failure were exercised. Peak VO(2) was 17.14 ± 7.58 mL/kg/min, VE/VCO(2) slope 50.1 ± 20.1, OUES 1.46 ± 0.68 L/min, and forced expiratory volume in 1 second (FEV(1) ) 1.88 ± 0.75 L. Peak VO(2) is substantially more sensitive to FEV(1) than ejection fraction (4.0 mL/kg/min difference between above- and below-median FEV(1) and 1.5 mL/kg/min between above- and below-median ejection fraction). OUES does not share this peculiar excess sensitivity to FEV(1) (0.12 L/min difference between above- and below-median FEV(1) and 0.01 L/min between above- and below-median ejection fraction). VE/VCO(2) slope has a borderline effect by FEV(1) (7.07 difference between above- and below-median FEV(1) and 2.07 between above- and below-median ejection fraction). Although widely used as a marker of heart failure severity, peak VO(2) is very sensitive to spirometry status and is indeed more affected by FEV(1) than by ejection fraction. OUES in contrast does not show this preferential sensitivity to impaired FEV(1).

Journal article

Yadav H, Unsworth B, Medlow K, Baruah R, Wasan BS, Mayet J, Francis DPet al., 2010, Usefulness of a Z-Score of E ' Versus Raw E ' Velocities to Detect Left Ventricular Dysfunction in Patients With Mitral or Aortic Regurgitation or Dilated Cardiomyopathy, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 106, Pages: 1187-1192, ISSN: 0002-9149

Journal article

Hadjiloizou N, Davies J, Baksi J, Malik I, Shai S, Aguado-Sierra J, Foale R, Parker K, Francis D, Hughes A, Mayet Jet al., 2010, Different effects of left ventricular hypertrophy secondary to hypertension and aortic stenosis on wave generation in the coronary arteries, JOURNAL OF HUMAN HYPERTENSION, Vol: 24, Pages: 703-703, ISSN: 0950-9240

Journal article

Bathula R, Hughes AD, Panerai R, Potter J, Thom SAM, Francis DP, Shore AC, Kooner J, Chaturvedi Net al., 2010, Indian Asians have poorer cardiovascular autonomic function than Europeans: this is due to greater hyperglycaemia and may contribute to their greater risk of heart disease, DIABETOLOGIA, Vol: 53, Pages: 2120-2128, ISSN: 0012-186X

Journal article

Sen S, Hadjiloizou N, Baksi J, Francis DP, Foale RA, Parker KH, Hughes AD, Chukwuemeka A, Casula R, Malik IS, Mikhail GW, Mayet J, Davies JEet al., 2010, Myocardial mechanism of angina in aortic stenosis identified in subjects undergoing transcatheter aortic valve implantation (TAVI), Publisher: NATURE PUBLISHING GROUP, Pages: 689-689, ISSN: 0950-9240

Conference paper

Baruah R, Francis DP, 2010, Chemoreflex sensitivity and congenital heart disease, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 144, Pages: 94-95, ISSN: 0167-5273

Journal article

Kyriacou A, Whinnett ZI, Pabari PA, Willson K, Lefroy D, Davies DW, Peters NS, Mayet J, Kanagaratnam P, Francis DPet al., 2010, Adaptation of non-invasive haemodynamic technologies and development of algorithms for cost effective, automated optimisation of cardiac resynchronisation devices, ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 418-418, ISSN: 0195-668X

Conference paper

Davies JE, Sen S, Hadjiloizou N, Francis DP, Mayet J, Parker KH, Hughes AD, Chukwuemeka A, Mikhail G, Malik ISet al., 2010, Reversed coronary reserve responses explain angina in severe aortic stenosis: assessment in subjects undergoing transcatheter aortic valve implantation (TAVI), ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 313-314, ISSN: 0195-668X

Conference paper

Ferenczi EA, Asaria P, Hughes AD, Chaturvedi N, Francis DPet al., 2010, Can a Statin Neutralize the Cardiovascular Risk of Unhealthy Dietary Choices?, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 106, Pages: 587-592, ISSN: 0002-9149

Journal article

Davies JE, Unsworth B, Francis DP, Casula R, Sutaria Net al., 2010, A Surgeon's Eye View Noninvasively, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 56, Pages: 454-454, ISSN: 0735-1097

Journal article

Davies JE, Sen S, Hadjiloizou N, Francis DP, Foale RA, Mayet J, Parker KH, Hughes AD, Chukwuemeka A, Mikhail G, Malik ISet al., 2010, ACUTE CHANGES IN CORONARY HAEMODYNAMIC IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE IMPLANTATION, Annual Conference and Exhibition of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A59-A59, ISSN: 1355-6037

Conference paper

Hadjiloizou N, Davies J, Baksi J, Malik I, Hughes A, Foale R, Parker K, Francis D, Mayet Jet al., 2010, DIFFERENTIAL EFFECTS OF HYPERTROPHY SECONDARY TO HYPERTENSION AND AORTIC STENOSIS ON CORONARY HAEMODYNAMICS, Annual Conference and Exhibition of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A58-A59, ISSN: 1355-6037

Conference paper

Baksi AJ, Treibel TA, Davies JE, Hadjiloizou N, Foale RA, Parker KH, Francis DP, Mayet J, Hughes ADet al., 2010, Changes in the Central Arterial Pressure Pulse With Aging Reply, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 2183-2184, ISSN: 0735-1097

Journal article

Salukhe TV, Briceno NI, Ferenczi EA, Sutton R, Francis DPet al., 2010, Is there benefit in implanting defibrillators in patients with severe heart failure?, HEART, Vol: 96, Pages: 599-603, ISSN: 1355-6037

Journal article

Dimopoulos K, Diller G-P, Petraco R, Koltsida E, Giannakoulas G, Tay EL, Best N, Piepoli MF, Francis DP, Poole-Wilson PA, Gatzoulis MAet al., 2010, Hyponatraemia: a strong predictor of mortality in adults with congenital heart disease, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 595-601, ISSN: 0195-668X

Journal article

Sharp ASP, Tapp RJ, Thom SAM, Francis DP, Hughes AD, Stanton AV, Zambanini A, O'Brien E, Chaturvedi N, Lyons S, Byrd S, Poulter NR, Sever PS, Mayet Jet al., 2010, Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 747-752, ISSN: 0195-668X

Journal article

Raphael C, Kanagaratnam P, Francis DP, 2010, Further Barriers to Conversations About Deactivation of Implantable Cardioverter-Defibrillators, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 701-702, ISSN: 0735-1097

Journal article

Unsworth B, Casula RP, Kyriacou AA, Yadav H, Chukwuemeka A, Cherian A, Stanbridge RDL, Athanasiou T, Mayet J, Francis DPet al., 2010, The right ventricular annular velocity reduction caused by coronary artery bypass graft surgery occurs at the moment of pericardial incision, AMERICAN HEART JOURNAL, Vol: 159, ISSN: 0002-8703

Journal article

Diller G-P, Lammers AE, Haworth SG, Dimopoulos K, Derrick G, Bonhoeffer P, Gatzoulis MA, Francis DPet al., 2010, A modelling study of atrial septostomy for pulmonary arterial hypertension, and its effect on the state of tissue oxygenation and systemic blood flow, CARDIOLOGY IN THE YOUNG, Vol: 20, Pages: 25-32, ISSN: 1047-9511

Journal article

Davies JE, Baksi J, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Foale RA, Malik IS, Tyberg JV, Parker KH, Mayet J, Hughes ADet al., 2010, The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 298, Pages: H580-H586, ISSN: 0363-6135

Journal article

Yadav H, Unsworth B, Fontana M, Diller G-P, Kyriacou A, Baruah R, Mayet J, Francis DFet al., 2010, Selective right ventricular impairment following coronary artery bypass graft surgery, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 37, Pages: 393-398, ISSN: 1010-7940

Journal article

Davies JE, Shanmuganathan M, Francis DP, Mayet J, Hackett DR, Hughes ADet al., 2010, Caution Using Brachial Systolic Pressure to Calibrate Radial Tonometric Pressure Waveforms: Lessons From Invasive Study, HYPERTENSION, Vol: 55, Pages: E4-E4, ISSN: 0194-911X

Journal article

Davies JE, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Malik IS, Parker KH, Hughes AD, Mayet Jet al., 2010, Augmentation of Coronary Blood Flow in Systole by Reflected Waves in the Proximal Aorta, 11th International Congress of the IUPESM/World Congress on Medical Physics and Biomedical Engineering, Publisher: SPRINGER, Pages: 61-64, ISSN: 1680-0737

Conference paper

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